Knee dGEMRIC at 7 T : Comparison against 1.5 T and evaluation of T1-mapping methods
(2018) In BMC Musculoskeletal Disorders 19(1).- Abstract
Background: dGEMRIC (delayed Gadolinium Enhanced Magnetic Resonance Image of Cartilage) is a well-established technique for cartilage quality assessment in osteoarthritis at clinical field strengths. The method is robust, but requires injection of contrast agent and a cumbersome examination procedure. New non-contrast-agent-based techniques for cartilage quality assessment are currently being developed at 7 T. However, dGEMRIC remains an important reference technique during this development. The aim of this work was to compare T1 mapping for dGEMRIC at 7 T and 1.5 T, and to evaluate three T1-mapping methods at 7 T. Methods: The knee of 10 healthy volunteers and 9 patients with early signs of cartilage degradation... (More)
Background: dGEMRIC (delayed Gadolinium Enhanced Magnetic Resonance Image of Cartilage) is a well-established technique for cartilage quality assessment in osteoarthritis at clinical field strengths. The method is robust, but requires injection of contrast agent and a cumbersome examination procedure. New non-contrast-agent-based techniques for cartilage quality assessment are currently being developed at 7 T. However, dGEMRIC remains an important reference technique during this development. The aim of this work was to compare T1 mapping for dGEMRIC at 7 T and 1.5 T, and to evaluate three T1-mapping methods at 7 T. Methods: The knee of 10 healthy volunteers and 9 patients with early signs of cartilage degradation were examined at 1.5 T and 7 T after a single (one) contrast agent injection (Gd-(DTPA)2-). Inversion recovery (IR) sequences were acquired at both field strengths, and at 7 T variable flip angle (VFA) and Look-Locker (LL) sequences were additionally acquired. T1 maps were calculated and average T1 values were estimated within superficial and deep regions-of-interest (ROIs) in the lateral and medial condyles, respectively. Results: T1 values were 1.8 (1.4-2.3) times longer at 7 T. A strong correlation was detected between 1.5 T and 7 T T1 values (r = 0.80). For IR, an additional inversion time was required to avoid underestimation (bias±limits of agreement - 127 ± 234 ms) due to the longer T1 values at 7 T. Out of the two 3D sequences tested, LL resulted in more accurate and precise T1 estimation compared to VFA (average bias±limits of agreement LL: 12 ± 202 ms compared to VFA: 25 ± 622 ms). For both, B1 correction improved agreement to IR. Conclusion: With an adapted sampling scheme, dGEMRIC T1 mapping is feasible at 7 T and correlates well to 1.5 T. If 3D is to be used for T1 mapping of the knee at 7 T, LL is preferred and VFA is not recommended. For VFA and LL, B1 correction is necessary for accurate T1 estimation.
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- author
- Peterson, Pernilla LU ; Tiderius, Carl Johan LU ; Olsson, Emma LU ; Lundin, Björn LU ; Olsson, Lars E. LU and Svensson, Jonas LU
- organization
- publishing date
- 2018-05-16
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- 7 T, Cartilage, dGEMRIC, Inversion recovery, Look-locker, Variable flip angle
- in
- BMC Musculoskeletal Disorders
- volume
- 19
- issue
- 1
- article number
- 149
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:85047206637
- pmid:29769051
- ISSN
- 1471-2474
- DOI
- 10.1186/s12891-018-2071-1
- language
- English
- LU publication?
- yes
- id
- 0e93449b-a92b-406b-9265-19d08a3432fb
- date added to LUP
- 2018-06-01 13:41:53
- date last changed
- 2024-06-24 15:20:07
@article{0e93449b-a92b-406b-9265-19d08a3432fb, abstract = {{<p>Background: dGEMRIC (delayed Gadolinium Enhanced Magnetic Resonance Image of Cartilage) is a well-established technique for cartilage quality assessment in osteoarthritis at clinical field strengths. The method is robust, but requires injection of contrast agent and a cumbersome examination procedure. New non-contrast-agent-based techniques for cartilage quality assessment are currently being developed at 7 T. However, dGEMRIC remains an important reference technique during this development. The aim of this work was to compare T<sub>1</sub> mapping for dGEMRIC at 7 T and 1.5 T, and to evaluate three T<sub>1</sub>-mapping methods at 7 T. Methods: The knee of 10 healthy volunteers and 9 patients with early signs of cartilage degradation were examined at 1.5 T and 7 T after a single (one) contrast agent injection (Gd-(DTPA)<sup>2-</sup>). Inversion recovery (IR) sequences were acquired at both field strengths, and at 7 T variable flip angle (VFA) and Look-Locker (LL) sequences were additionally acquired. T<sub>1</sub> maps were calculated and average T<sub>1</sub> values were estimated within superficial and deep regions-of-interest (ROIs) in the lateral and medial condyles, respectively. Results: T<sub>1</sub> values were 1.8 (1.4-2.3) times longer at 7 T. A strong correlation was detected between 1.5 T and 7 T T<sub>1</sub> values (r = 0.80). For IR, an additional inversion time was required to avoid underestimation (bias±limits of agreement - 127 ± 234 ms) due to the longer T<sub>1</sub> values at 7 T. Out of the two 3D sequences tested, LL resulted in more accurate and precise T<sub>1</sub> estimation compared to VFA (average bias±limits of agreement LL: 12 ± 202 ms compared to VFA: 25 ± 622 ms). For both, B<sub>1</sub> correction improved agreement to IR. Conclusion: With an adapted sampling scheme, dGEMRIC T<sub>1</sub> mapping is feasible at 7 T and correlates well to 1.5 T. If 3D is to be used for T<sub>1</sub> mapping of the knee at 7 T, LL is preferred and VFA is not recommended. For VFA and LL, B<sub>1</sub> correction is necessary for accurate T<sub>1</sub> estimation.</p>}}, author = {{Peterson, Pernilla and Tiderius, Carl Johan and Olsson, Emma and Lundin, Björn and Olsson, Lars E. and Svensson, Jonas}}, issn = {{1471-2474}}, keywords = {{7 T; Cartilage; dGEMRIC; Inversion recovery; Look-locker; Variable flip angle}}, language = {{eng}}, month = {{05}}, number = {{1}}, publisher = {{BioMed Central (BMC)}}, series = {{BMC Musculoskeletal Disorders}}, title = {{Knee dGEMRIC at 7 T : Comparison against 1.5 T and evaluation of T<sub>1</sub>-mapping methods}}, url = {{http://dx.doi.org/10.1186/s12891-018-2071-1}}, doi = {{10.1186/s12891-018-2071-1}}, volume = {{19}}, year = {{2018}}, }