Enhanced vasodilator responses to calcitonin gene-related peptide (CGRP) in subcutaneous arteries in human hypertension.
(2002) In Journal of Human Hypertension 16(1). p.53-59- Abstract
- Isolated segments (1-2 mm) of small subcutaneous arteries (diameter 0.1-0.9 mm) and veins (0.1-1.0 mm) from patients with hypertension (essential n = 13, renovascular n = 6) and controls (n = 17) were examined. The relaxant responses to the sensory transmitters calcitonin gene-related peptide (CGRP) and substance P, and the contractile responses to potassium and noradrenaline were studied. Enhanced dilatory responses (E(max)) but no change in sensitivity (pEC50) were demonstrated in the arteries but not in the veins to CGRP in hypertensives (P < 0.01) as compared with normotensives, and in the hypertensive subgroups (essential hypertension, P < 0.05; renovascular hypertension, P< 0.05). The relaxant responses to substance P were... (More)
- Isolated segments (1-2 mm) of small subcutaneous arteries (diameter 0.1-0.9 mm) and veins (0.1-1.0 mm) from patients with hypertension (essential n = 13, renovascular n = 6) and controls (n = 17) were examined. The relaxant responses to the sensory transmitters calcitonin gene-related peptide (CGRP) and substance P, and the contractile responses to potassium and noradrenaline were studied. Enhanced dilatory responses (E(max)) but no change in sensitivity (pEC50) were demonstrated in the arteries but not in the veins to CGRP in hypertensives (P < 0.01) as compared with normotensives, and in the hypertensive subgroups (essential hypertension, P < 0.05; renovascular hypertension, P< 0.05). The relaxant responses to substance P were not altered either in arteries or in veins of hypertensives. Furthermore, there were no differences in the contractile responses to 60 mM potassium or to 10 microM noradrenaline between the groups. The results suggest that the enhanced vasodilator response to CGRP in hypertension is an adaptive reaction. The elevated blood pressure may be augmented by vasodilatory activity since different subgroups of hypertensives showed the same results. However, other common characteristics of hypertension (eg, medication, metabolic disturbances) may have also influenced the results. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/106062
- author
- Lind, H and Edvinsson, Lars LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Human, Middle Age, Male, Hypertension/*physiopathology, Muscle, Smooth/drug effects/physiopathology, Neuromuscular Depolarizing Agents/pharmacology, Norepinephrine/pharmacology, Potassium/pharmacology, Skin/*blood supply/drug effects/*physiopathology, Substance P/*pharmacology, Support, Non-U.S. Gov't, Vasoconstrictor Agents/pharmacology, Vasodilation/*drug effects/*physiology, Veins/*drug effects/*physiopathology, Vasomotor System/drug effects/physiopathology, Female, Calcitonin Gene-Related Peptide/*pharmacology, Arteries/*drug effects/*physiopathology
- in
- Journal of Human Hypertension
- volume
- 16
- issue
- 1
- pages
- 53 - 59
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:11840230
- wos:000173900500008
- scopus:0036166444
- ISSN
- 1476-5527
- DOI
- 10.1038/sj/jhh/1001294
- language
- English
- LU publication?
- yes
- id
- 0e966a66-dfa9-4fb5-8f29-694f53bb0e38 (old id 106062)
- alternative location
- http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11840230&dopt=Abstract
- date added to LUP
- 2016-04-01 11:53:11
- date last changed
- 2024-01-08 00:14:48
@article{0e966a66-dfa9-4fb5-8f29-694f53bb0e38,
abstract = {{Isolated segments (1-2 mm) of small subcutaneous arteries (diameter 0.1-0.9 mm) and veins (0.1-1.0 mm) from patients with hypertension (essential n = 13, renovascular n = 6) and controls (n = 17) were examined. The relaxant responses to the sensory transmitters calcitonin gene-related peptide (CGRP) and substance P, and the contractile responses to potassium and noradrenaline were studied. Enhanced dilatory responses (E(max)) but no change in sensitivity (pEC50) were demonstrated in the arteries but not in the veins to CGRP in hypertensives (P < 0.01) as compared with normotensives, and in the hypertensive subgroups (essential hypertension, P < 0.05; renovascular hypertension, P< 0.05). The relaxant responses to substance P were not altered either in arteries or in veins of hypertensives. Furthermore, there were no differences in the contractile responses to 60 mM potassium or to 10 microM noradrenaline between the groups. The results suggest that the enhanced vasodilator response to CGRP in hypertension is an adaptive reaction. The elevated blood pressure may be augmented by vasodilatory activity since different subgroups of hypertensives showed the same results. However, other common characteristics of hypertension (eg, medication, metabolic disturbances) may have also influenced the results.}},
author = {{Lind, H and Edvinsson, Lars}},
issn = {{1476-5527}},
keywords = {{Human; Middle Age; Male; Hypertension/*physiopathology; Muscle; Smooth/drug effects/physiopathology; Neuromuscular Depolarizing Agents/pharmacology; Norepinephrine/pharmacology; Potassium/pharmacology; Skin/*blood supply/drug effects/*physiopathology; Substance P/*pharmacology; Support; Non-U.S. Gov't; Vasoconstrictor Agents/pharmacology; Vasodilation/*drug effects/*physiology; Veins/*drug effects/*physiopathology; Vasomotor System/drug effects/physiopathology; Female; Calcitonin Gene-Related Peptide/*pharmacology; Arteries/*drug effects/*physiopathology}},
language = {{eng}},
number = {{1}},
pages = {{53--59}},
publisher = {{Nature Publishing Group}},
series = {{Journal of Human Hypertension}},
title = {{Enhanced vasodilator responses to calcitonin gene-related peptide (CGRP) in subcutaneous arteries in human hypertension.}},
url = {{http://dx.doi.org/10.1038/sj/jhh/1001294}},
doi = {{10.1038/sj/jhh/1001294}},
volume = {{16}},
year = {{2002}},
}