C-erbB2, p27 and G1/S aberrations in human primary breast cancer
(2003) In Anticancer research 23(3A). p.2053-2061- Abstract
- Background: C-erbB2 is overexpressed in approximately one-fourth of human breast cancers. In spite of numerous reports suggesting a connection of c-erbB2 overexpression with cell cycle regulation through p27, D cyclins and c-myc. the relationship between c-erbB2 and proliferation through de-regulation of the pRb pathway in primaty breast cancer has not been fully clarified. Materials and Methods: For this purpose we compared the expression of c-erbB2 in a total of 10.5 primary breast tumours with a variety of cell cycle proteins and clinical parameters. Results: GerbB2 was strongly con-elated with down-regulation of p27 and overexpression of c-erbB2 was', as expected, associated with poor survival. However, there was no correlation with... (More)
- Background: C-erbB2 is overexpressed in approximately one-fourth of human breast cancers. In spite of numerous reports suggesting a connection of c-erbB2 overexpression with cell cycle regulation through p27, D cyclins and c-myc. the relationship between c-erbB2 and proliferation through de-regulation of the pRb pathway in primaty breast cancer has not been fully clarified. Materials and Methods: For this purpose we compared the expression of c-erbB2 in a total of 10.5 primary breast tumours with a variety of cell cycle proteins and clinical parameters. Results: GerbB2 was strongly con-elated with down-regulation of p27 and overexpression of c-erbB2 was', as expected, associated with poor survival. However, there was no correlation with proliferation. There was, nevertheless, an association between c-erbB2 and proliferation in certain subtypes of breast cancer, as in oestrogen-receptor-positive e tumours, tumours with high cyclin D1 and in tumours with an overall linear pRb pathway, i.e. tumours with a preserved linearity between cyclin D1, pRb phosphorylation and proliferation. Conclusion: Our results suggest that c-erbB2 may have alternative functions in different subtypes of breast cancer, and further stress that c-erbB2, in addition to promoting proliferation, also functions through other mechanisms in breast cancer. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/305807
- author
- Loden, M ; Perris, F ; Nielsen, NH ; Emdin, SO and Landberg, Göran LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- proliferation, pRb pathway, cyclins, p27, breast cancer, c-erbB2
- in
- Anticancer research
- volume
- 23
- issue
- 3A
- pages
- 2053 - 2061
- publisher
- International Institute of Cancer Research
- external identifiers
-
- wos:000184359100009
- scopus:0041304766
- ISSN
- 1791-7530
- language
- English
- LU publication?
- yes
- id
- 0eae8cb9-97e8-4c6c-8e71-0464a32b7d2c (old id 305807)
- date added to LUP
- 2016-04-01 12:25:09
- date last changed
- 2022-01-27 03:27:29
@article{0eae8cb9-97e8-4c6c-8e71-0464a32b7d2c,
abstract = {{Background: C-erbB2 is overexpressed in approximately one-fourth of human breast cancers. In spite of numerous reports suggesting a connection of c-erbB2 overexpression with cell cycle regulation through p27, D cyclins and c-myc. the relationship between c-erbB2 and proliferation through de-regulation of the pRb pathway in primaty breast cancer has not been fully clarified. Materials and Methods: For this purpose we compared the expression of c-erbB2 in a total of 10.5 primary breast tumours with a variety of cell cycle proteins and clinical parameters. Results: GerbB2 was strongly con-elated with down-regulation of p27 and overexpression of c-erbB2 was', as expected, associated with poor survival. However, there was no correlation with proliferation. There was, nevertheless, an association between c-erbB2 and proliferation in certain subtypes of breast cancer, as in oestrogen-receptor-positive e tumours, tumours with high cyclin D1 and in tumours with an overall linear pRb pathway, i.e. tumours with a preserved linearity between cyclin D1, pRb phosphorylation and proliferation. Conclusion: Our results suggest that c-erbB2 may have alternative functions in different subtypes of breast cancer, and further stress that c-erbB2, in addition to promoting proliferation, also functions through other mechanisms in breast cancer.}},
author = {{Loden, M and Perris, F and Nielsen, NH and Emdin, SO and Landberg, Göran}},
issn = {{1791-7530}},
keywords = {{proliferation; pRb pathway; cyclins; p27; breast cancer; c-erbB2}},
language = {{eng}},
number = {{3A}},
pages = {{2053--2061}},
publisher = {{International Institute of Cancer Research}},
series = {{Anticancer research}},
title = {{C-erbB2, p27 and G1/S aberrations in human primary breast cancer}},
volume = {{23}},
year = {{2003}},
}