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Patch Testing with a New Composition of the Mercapto Mix - A Multicenter Study from the International Contact Dermatitis Research Group

Isaksson, Marléne LU ; Andersen, Klaus E. ; Cannavó, Alicia ; Elsner, Peter ; Goh, Chee Leok ; Gonçalo, Margarida ; Goossens, An ; Hadzavdic, Suzana Ljubojevic ; Pratt, Melanie and Puangpet, Pailin , et al. (2021) In Dermatitis 32(3). p.160-163
Abstract

Background Mercaptobenzothiazole compounds are associated with allergic contact dermatitis caused by rubber products. Several screening substances have been used for patch testing. Objective To compare the frequency of positive test reactions to a mercapto mix containing a higher concentration of 2-mercaptobenzothiazole with reactions to the combination of 2-mercaptobenzothiazole 2.0% and mercapto mix 2.0%. Methods There were 7103 dermatitis patients in 12 International Contact Dermatitis Research Group dermatology departments who were patch tested with 2-mercaptobenzothiazole 2.0% petrolatum (pet.), mercapto mix 2.0% pet., and mercapto mix 3.5% pet. Results Contact allergy to the 3 test preparations varied among the 12 centers:... (More)

Background Mercaptobenzothiazole compounds are associated with allergic contact dermatitis caused by rubber products. Several screening substances have been used for patch testing. Objective To compare the frequency of positive test reactions to a mercapto mix containing a higher concentration of 2-mercaptobenzothiazole with reactions to the combination of 2-mercaptobenzothiazole 2.0% and mercapto mix 2.0%. Methods There were 7103 dermatitis patients in 12 International Contact Dermatitis Research Group dermatology departments who were patch tested with 2-mercaptobenzothiazole 2.0% petrolatum (pet.), mercapto mix 2.0% pet., and mercapto mix 3.5% pet. Results Contact allergy to the 3 test preparations varied among the 12 centers: 2-mercaptobenzothiazole 2.0% pet. (0-2.4%), mercapto mix 2.0% pet. (0-4.9%), and mercapto mix 3.5% pet. (0-1.4%). 2-Mercaptobenzothiazole 2.0% and mercapto mix 2.0% detected a few more positive patients compared with mercapto mix 3.5%, but the difference was statistically insignificant (mercapto mix 2.0% pet., P = 1.0; 2-mercapto-benzothiazole 2.0% pet., P = 0.66). Conclusions Mercapto mix 3.5% pet. is not better than 2-mercaptobenzothiazole 2.0% and mercapto mix 2.0% by a difference that is significant. By using only 1 test preparation (mercapto mix 3.5%), an additional hapten could be tested. No cases of suspected/proven patch test sensitization were registered.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Dermatitis
volume
32
issue
3
pages
4 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:85106610835
  • pmid:33405485
ISSN
1710-3568
DOI
10.1097/DER.0000000000000669
language
English
LU publication?
yes
id
0eba84ce-68d6-46d9-96a3-b0bac6140506
date added to LUP
2021-06-09 11:39:59
date last changed
2024-03-23 05:42:41
@article{0eba84ce-68d6-46d9-96a3-b0bac6140506,
  abstract     = {{<p>Background Mercaptobenzothiazole compounds are associated with allergic contact dermatitis caused by rubber products. Several screening substances have been used for patch testing. Objective To compare the frequency of positive test reactions to a mercapto mix containing a higher concentration of 2-mercaptobenzothiazole with reactions to the combination of 2-mercaptobenzothiazole 2.0% and mercapto mix 2.0%. Methods There were 7103 dermatitis patients in 12 International Contact Dermatitis Research Group dermatology departments who were patch tested with 2-mercaptobenzothiazole 2.0% petrolatum (pet.), mercapto mix 2.0% pet., and mercapto mix 3.5% pet. Results Contact allergy to the 3 test preparations varied among the 12 centers: 2-mercaptobenzothiazole 2.0% pet. (0-2.4%), mercapto mix 2.0% pet. (0-4.9%), and mercapto mix 3.5% pet. (0-1.4%). 2-Mercaptobenzothiazole 2.0% and mercapto mix 2.0% detected a few more positive patients compared with mercapto mix 3.5%, but the difference was statistically insignificant (mercapto mix 2.0% pet., P = 1.0; 2-mercapto-benzothiazole 2.0% pet., P = 0.66). Conclusions Mercapto mix 3.5% pet. is not better than 2-mercaptobenzothiazole 2.0% and mercapto mix 2.0% by a difference that is significant. By using only 1 test preparation (mercapto mix 3.5%), an additional hapten could be tested. No cases of suspected/proven patch test sensitization were registered.</p>}},
  author       = {{Isaksson, Marléne and Andersen, Klaus E. and Cannavó, Alicia and Elsner, Peter and Goh, Chee Leok and Gonçalo, Margarida and Goossens, An and Hadzavdic, Suzana Ljubojevic and Pratt, Melanie and Puangpet, Pailin and Sasseville, Denis and Verma, Kaushal and Bruze, Magnus}},
  issn         = {{1710-3568}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{160--163}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Dermatitis}},
  title        = {{Patch Testing with a New Composition of the Mercapto Mix - A Multicenter Study from the International Contact Dermatitis Research Group}},
  url          = {{http://dx.doi.org/10.1097/DER.0000000000000669}},
  doi          = {{10.1097/DER.0000000000000669}},
  volume       = {{32}},
  year         = {{2021}},
}