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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Berndt, Sonja I.; Gustafsson, Stefan; Maegi, Reedik; Ganna, Andrea; Wheeler, Eleanor; Feitosa, Mary F.; Justice, Anne E.; Monda, Keri L.; Croteau-Chonka, Damien C. and Day, Felix R., et al. (2013) In Nature Genetics 45(5). p.501-512
Abstract
Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between... (More)
Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups. (Less)
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Nature Genetics
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45
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5
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501 - 512
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Nature Publishing Group
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  • scopus:84878594902
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1546-1718
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10.1038/ng.2606
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English
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0ed1c4df-424a-4149-9aa4-3ff244561c28 (old id 3843496)
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2013-07-01 07:01:34
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@article{0ed1c4df-424a-4149-9aa4-3ff244561c28,
  abstract     = {Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.},
  author       = {Berndt, Sonja I. and Gustafsson, Stefan and Maegi, Reedik and Ganna, Andrea and Wheeler, Eleanor and Feitosa, Mary F. and Justice, Anne E. and Monda, Keri L. and Croteau-Chonka, Damien C. and Day, Felix R. and Esko, Tonu and Fall, Tove and Ferreira, Teresa and Gentilini, Davide and Jackson, Anne U. and Luan, Jian'an and Randall, Joshua C. and Vedantam, Sailaja and Willer, Cristen J. and Winkler, Thomas W. and Wood, Andrew R. and Workalemahu, Tsegaselassie and Hu, Yi-Juan and Lee, Sang Hong and Liang, Liming and Lin, Dan-Yu and Min, Josine L. and Neale, Benjamin M. and Thorleifsson, Gudmar and Yang, Jian and Albrecht, Eva and Amin, Najaf and Bragg-Gresham, Jennifer L. and Cadby, Gemma and den Heijer, Martin and Eklund, Niina and Fischer, Krista and Goel, Anuj and Hottenga, Jouke-Jan and Huffman, Jennifer E. and Jarick, Ivonne and Johansson, Asa and Johnson, Toby and Kanoni, Stavroula and Kleber, Marcus E. and Koenig, Inke R. and Kristiansson, Kati and Kutalik, Zoltn and Lamina, Claudia and Lecoeur, Cecile and Li, Guo and Mangino, Massimo and McArdle, Wendy L. and Medina-Gomez, Carolina and Mueller-Nurasyid, Martina and Ngwa, Julius S. and Nolte, Ilja M. and Paternoster, Lavinia and Pechlivanis, Sonali and Perola, Markus and Peters, Marjolein J. and Preuss, Michael and Rose, Lynda M. and Shi, Jianxin and Shungin, Dmitry and Smith, Albert Vernon and Strawbridge, Rona J. and Surakka, Ida and Teumer, Alexander and Trip, Mieke D. and Tyrer, Jonathan and Van Vliet-Ostaptchouk, Jana V. and Vandenput, Liesbeth and Waite, Lindsay L. and Zhao, Jing Hua and Absher, Devin and Asselbergs, Folkert W. and Atalay, Mustafa and Attwood, Antony P. and Balmforth, Anthony J. and Basart, Hanneke and Beilby, John and Bonnycastle, Lori L. and Brambilla, Paolo and Bruinenberg, Marcel and Campbell, Harry and Chasman, Daniel I. and Chines, Peter S. and Collins, Francis S. and Connell, John M. and Cookson, William O. and de Faire, Ulf and de Vegt, Femmie and Dei, Mariano and Dimitriou, Maria and Edkins, Sarah and Estrada, Karol and Evans, David M. and Farrall, Martin and Ferrario, Marco M. and Ferrieres, Jean and Franke, Lude and Frau, Francesca and Gejman, Pablo V. and Grallert, Harald and Groenberg, Henrik and Gudnason, Vilmundur and Hall, Alistair S. and Hall, Per and Hartikainen, Anna-Liisa and Hayward, Caroline and Heard-Costa, Nancy L. and Heath, Andrew C. and Hebebrand, Johannes and Homuth, Georg and Hu, Frank B. and Hunt, Sarah E. and Hyppoenen, Elina and Iribarren, Carlos and Jacobs, Kevin B. and Jansson, John-Olov and Jula, Antti and Kahonen, Mika and Kathiresan, Sekar and Kee, Frank and Khaw, Kay-Tee and Kivimaki, Mika and Koenig, Wolfgang and Kraja, Aldi T. and Kumari, Meena and Kuulasmaa, Kari and Kuusisto, Johanna and Laitinen, Jaana H. and Lakka, Timo A. and Langenberg, Claudia and Launer, Lenore J. and Lind, Lars and Lindstrom, Jaana and Liu, Jianjun and Liuzzi, Antonio and Lokki, Marja-Liisa and Lorentzon, Mattias and Madden, Pamela A. and Magnusson, Patrik K. and Manunta, Paolo and Marek, Diana and Maerz, Winfried and Leach, Irene Mateo and McKnight, Barbara and Medland, Sarah E. and Mihailov, Evelin and Milani, Lili and Montgomery, Grant W. and Mooser, Vincent and Muehleisen, Thomas W. and Munroe, Patricia B. and Musk, Arthur W. and Narisu, Narisu and Navis, Gerjan and Nicholson, George and Nohr, Ellen A. and Ong, Ken K. and Oostra, Ben A. and Palmer, Colin N. 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F. and Ingelsson, Erik},
  issn         = {1546-1718},
  language     = {eng},
  number       = {5},
  pages        = {501--512},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture},
  url          = {http://dx.doi.org/10.1038/ng.2606},
  volume       = {45},
  year         = {2013},
}