A glycyl radical site in the crystal structure of a class III ribonucleotide reductase
(1999) In Science 283(5407). p.1499-1504- Abstract
Ribonucleotide reductases catalyze the reduction of ribonucleotides to deoxyribonucleotides. Three classes have been identified, all using free- radical chemistry but based on different cofactors. Classes I and II have been shown to be evolutionarily related, whereas the origin of anaerobic class III has remained elusive. The structure of a class III enzyme suggests a common origin for the three classes but shows differences in the active site that can be understood on the basis of the radical-initiation system and source of reductive electrons, as well as a unique protein glycyl radical site. A possible evolutionary relationship between early deoxyribonucleotide metabolism and primary anaerobic metabolism is suggested.
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- author
- Logan, Derek T.
LU
; Andersson, Jessica ; Sjöberg, Britt-Marie and Nordlund, Pär
- publishing date
- 1999-03-05
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Science
- volume
- 283
- issue
- 5407
- pages
- 6 pages
- publisher
- American Association for the Advancement of Science (AAAS)
- external identifiers
-
- scopus:0033525599
- pmid:10066165
- ISSN
- 0036-8075
- DOI
- 10.1126/science.283.5407.1499
- language
- English
- LU publication?
- no
- id
- 0f163fa4-5dab-497f-9d61-d89d60ba8eb3
- date added to LUP
- 2022-04-25 11:24:56
- date last changed
- 2024-01-03 10:33:53
@article{0f163fa4-5dab-497f-9d61-d89d60ba8eb3, abstract = {{<p>Ribonucleotide reductases catalyze the reduction of ribonucleotides to deoxyribonucleotides. Three classes have been identified, all using free- radical chemistry but based on different cofactors. Classes I and II have been shown to be evolutionarily related, whereas the origin of anaerobic class III has remained elusive. The structure of a class III enzyme suggests a common origin for the three classes but shows differences in the active site that can be understood on the basis of the radical-initiation system and source of reductive electrons, as well as a unique protein glycyl radical site. A possible evolutionary relationship between early deoxyribonucleotide metabolism and primary anaerobic metabolism is suggested.</p>}}, author = {{Logan, Derek T. and Andersson, Jessica and Sjöberg, Britt-Marie and Nordlund, Pär}}, issn = {{0036-8075}}, language = {{eng}}, month = {{03}}, number = {{5407}}, pages = {{1499--1504}}, publisher = {{American Association for the Advancement of Science (AAAS)}}, series = {{Science}}, title = {{A glycyl radical site in the crystal structure of a class III ribonucleotide reductase}}, url = {{http://dx.doi.org/10.1126/science.283.5407.1499}}, doi = {{10.1126/science.283.5407.1499}}, volume = {{283}}, year = {{1999}}, }