Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Five Pathogenetic Classifications for Alloimmune Hemolytic Disease of the Fetus And Newborn

Ohto, Hitoshi ; Nollet, Kenneth E. and Storry, Jill R. LU (2026) In Transfusion Medicine Reviews 40(1).
Abstract

Maternal alloantibody-induced hemolytic disease of the fetus and newborn (HDFN) remains a significant concern worldwide. Alloimmune HDFN can be pathogenetically named by the specific alloantibodies involved. Moreover, four mechanistic pathway types are generally recognized in clinical practice: classical or extravascular hemolysis; immune-pressure-escaped, also known as antibody-mediated antigen-modulation; apoptotic or dysplastic; and failed transaction. Another proposed pathway is worthy of discussion: lactation-mediated. Management strategies for alloimmune HDFN should take account of these underlying mechanisms.

Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alloimmune, Antibody, Blood type, HDFN, Hemolytic disease, Kell, RhD
in
Transfusion Medicine Reviews
volume
40
issue
1
article number
150958
publisher
W.B. Saunders
external identifiers
  • pmid:41520492
  • scopus:105027019651
ISSN
0887-7963
DOI
10.1016/j.tmrv.2025.150958
language
English
LU publication?
yes
id
0f36be5b-573e-4dac-9c61-f6d7b1d1a1ff
date added to LUP
2026-03-26 10:50:04
date last changed
2026-05-07 15:59:53
@article{0f36be5b-573e-4dac-9c61-f6d7b1d1a1ff,
  abstract     = {{<p>Maternal alloantibody-induced hemolytic disease of the fetus and newborn (HDFN) remains a significant concern worldwide. Alloimmune HDFN can be pathogenetically named by the specific alloantibodies involved. Moreover, four mechanistic pathway types are generally recognized in clinical practice: classical or extravascular hemolysis; immune-pressure-escaped, also known as antibody-mediated antigen-modulation; apoptotic or dysplastic; and failed transaction. Another proposed pathway is worthy of discussion: lactation-mediated. Management strategies for alloimmune HDFN should take account of these underlying mechanisms.</p>}},
  author       = {{Ohto, Hitoshi and Nollet, Kenneth E. and Storry, Jill R.}},
  issn         = {{0887-7963}},
  keywords     = {{Alloimmune; Antibody; Blood type; HDFN; Hemolytic disease; Kell; RhD}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{W.B. Saunders}},
  series       = {{Transfusion Medicine Reviews}},
  title        = {{Five Pathogenetic Classifications for Alloimmune Hemolytic Disease of the Fetus And Newborn}},
  url          = {{http://dx.doi.org/10.1016/j.tmrv.2025.150958}},
  doi          = {{10.1016/j.tmrv.2025.150958}},
  volume       = {{40}},
  year         = {{2026}},
}