Tuning the performance of an artificial protein motor
Kuwada, Nathan J. ; Zuckermann, Martin J. ; Bromley, Elizabeth H. C. ; Sessions, Richard B. ; Curmi, Paul M. G. ; Forde, Nancy R. ; Woolfson, Derek N. and Linke, Heiner LU
(2011)
In Physical Review E (Statistical, Nonlinear, and Soft Matter Physics)
84(3).
- Abstract
- The Tumbleweed (TW) is a concept for an artificial, tri-pedal, protein-based motor designed to move unidirectionally along a linear track by a diffusive tumbling motion. Artificial motors offer the unique opportunity to explore how motor performance depends on design details in a way that is open to experimental investigation. Prior studies have shown that TW's ability to complete many successive steps can be critically dependent on the motor's diffusional step time. Here, we present a simulation study targeted at determining how to minimize the diffusional step time of the TW motor as a function of two particular design choices: nonspecific motor-track interactions and molecular flexibility. We determine an optimal nonspecific interaction... (More)
- The Tumbleweed (TW) is a concept for an artificial, tri-pedal, protein-based motor designed to move unidirectionally along a linear track by a diffusive tumbling motion. Artificial motors offer the unique opportunity to explore how motor performance depends on design details in a way that is open to experimental investigation. Prior studies have shown that TW's ability to complete many successive steps can be critically dependent on the motor's diffusional step time. Here, we present a simulation study targeted at determining how to minimize the diffusional step time of the TW motor as a function of two particular design choices: nonspecific motor-track interactions and molecular flexibility. We determine an optimal nonspecific interaction strength and establish a set of criteria for optimal molecular flexibility as a function of the nonspecific interaction. We discuss our results in the context of similarities to biological, linear stepping diffusive molecular motors with the aim of identifying general engineering principles for protein motors. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2207042
- author
- Kuwada, Nathan J.
; Zuckermann, Martin J.
; Bromley, Elizabeth H. C.
; Sessions, Richard B.
; Curmi, Paul M. G.
; Forde, Nancy R.
; Woolfson, Derek N.
and Linke, Heiner
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Physical Review E (Statistical, Nonlinear, and Soft Matter Physics)
- volume
- 84
- issue
- 3
- article number
- 031922
- publisher
- American Physical Society
- external identifiers
-
- wos:000296498900005
- scopus:80053126280
- pmid:22060418
- ISSN
- 1539-3755
- DOI
- 10.1103/PhysRevE.84.031922
- language
- English
- LU publication?
- yes
- id
- 0f6363e2-4af8-4daf-a0ab-26ce5948a442 (old id 2207042)
- date added to LUP
- 2016-04-01 11:04:25
- date last changed
- 2023-08-31 18:02:17
@article{0f6363e2-4af8-4daf-a0ab-26ce5948a442,
abstract = {{The Tumbleweed (TW) is a concept for an artificial, tri-pedal, protein-based motor designed to move unidirectionally along a linear track by a diffusive tumbling motion. Artificial motors offer the unique opportunity to explore how motor performance depends on design details in a way that is open to experimental investigation. Prior studies have shown that TW's ability to complete many successive steps can be critically dependent on the motor's diffusional step time. Here, we present a simulation study targeted at determining how to minimize the diffusional step time of the TW motor as a function of two particular design choices: nonspecific motor-track interactions and molecular flexibility. We determine an optimal nonspecific interaction strength and establish a set of criteria for optimal molecular flexibility as a function of the nonspecific interaction. We discuss our results in the context of similarities to biological, linear stepping diffusive molecular motors with the aim of identifying general engineering principles for protein motors.}},
author = {{Kuwada, Nathan J. and Zuckermann, Martin J. and Bromley, Elizabeth H. C. and Sessions, Richard B. and Curmi, Paul M. G. and Forde, Nancy R. and Woolfson, Derek N. and Linke, Heiner}},
issn = {{1539-3755}},
language = {{eng}},
number = {{3}},
publisher = {{American Physical Society}},
series = {{Physical Review E (Statistical, Nonlinear, and Soft Matter Physics)}},
title = {{Tuning the performance of an artificial protein motor}},
url = {{http://dx.doi.org/10.1103/PhysRevE.84.031922}},
doi = {{10.1103/PhysRevE.84.031922}},
volume = {{84}},
year = {{2011}},
}