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Alternative oxidase : a target and regulator of stress responses

Van Aken, Olivier LU ; Giraud, Estelle; Clifton, Rachel and Whelan, James (2009) In Physiologia Plantarum 137(4). p.61-354
Abstract

The alternative oxidase (AOX) is found in all plants examined to date, fungi and lower invertebrates. We propose that AOX is not only part of the stress response in plants, but it also plays a central role in defining the stress response. Three lines of evidence support this proposal: (1) The absence of AOX leads to an alteration of stress defences in normal and stress conditions, (2) the expression of AOX is triggered by a variety of signals indicating that it is a common response and (3) AOX acts as a buffer that determines the threshold for the induction of programmed cell death. Therefore, AOX is not only one of many components involved in the defence response, its activity or lack of activity leads to a radical alteration of the... (More)

The alternative oxidase (AOX) is found in all plants examined to date, fungi and lower invertebrates. We propose that AOX is not only part of the stress response in plants, but it also plays a central role in defining the stress response. Three lines of evidence support this proposal: (1) The absence of AOX leads to an alteration of stress defences in normal and stress conditions, (2) the expression of AOX is triggered by a variety of signals indicating that it is a common response and (3) AOX acts as a buffer that determines the threshold for the induction of programmed cell death. Therefore, AOX is not only one of many components involved in the defence response, its activity or lack of activity leads to a radical alteration of the defence equilibrium at a cellular level and thus it plays a central role in programming the stress response. This programming role of AOX can be achieved directly by its ability to suppress the induction of reactive oxygen species (ROS) and indirectly by causing changes in the energy status of cells owing to the non-phosphorylating nature of the alternative respiratory pathway. The latter is likely achieved in combination with a variety of alternative NAD(P)H dehydrogenases, that are co-regulated with AOX. Additionally, we explore the possible function of AOX as a component of the stress response beyond the plant frontier.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Apoptosis, Mitochondrial Proteins, Oxidoreductases, Plant Cells, Plant Proteins, Plants, Signal Transduction, Stress, Physiological
in
Physiologia Plantarum
volume
137
issue
4
pages
8 pages
publisher
Wiley Online Library
external identifiers
  • scopus:70450260721
ISSN
0031-9317
DOI
10.1111/j.1399-3054.2009.01240.x
language
English
LU publication?
no
id
0f652f2d-1fcd-4d3e-b3d2-7ea27b0ba759
date added to LUP
2017-05-09 10:09:44
date last changed
2017-12-10 05:08:12
@article{0f652f2d-1fcd-4d3e-b3d2-7ea27b0ba759,
  abstract     = {<p>The alternative oxidase (AOX) is found in all plants examined to date, fungi and lower invertebrates. We propose that AOX is not only part of the stress response in plants, but it also plays a central role in defining the stress response. Three lines of evidence support this proposal: (1) The absence of AOX leads to an alteration of stress defences in normal and stress conditions, (2) the expression of AOX is triggered by a variety of signals indicating that it is a common response and (3) AOX acts as a buffer that determines the threshold for the induction of programmed cell death. Therefore, AOX is not only one of many components involved in the defence response, its activity or lack of activity leads to a radical alteration of the defence equilibrium at a cellular level and thus it plays a central role in programming the stress response. This programming role of AOX can be achieved directly by its ability to suppress the induction of reactive oxygen species (ROS) and indirectly by causing changes in the energy status of cells owing to the non-phosphorylating nature of the alternative respiratory pathway. The latter is likely achieved in combination with a variety of alternative NAD(P)H dehydrogenases, that are co-regulated with AOX. Additionally, we explore the possible function of AOX as a component of the stress response beyond the plant frontier.</p>},
  author       = {Van Aken, Olivier and Giraud, Estelle and Clifton, Rachel and Whelan, James},
  issn         = {0031-9317},
  keyword      = {Apoptosis,Mitochondrial Proteins,Oxidoreductases,Plant Cells,Plant Proteins,Plants,Signal Transduction,Stress, Physiological},
  language     = {eng},
  number       = {4},
  pages        = {61--354},
  publisher    = {Wiley Online Library},
  series       = {Physiologia Plantarum},
  title        = {Alternative oxidase : a target and regulator of stress responses},
  url          = {http://dx.doi.org/10.1111/j.1399-3054.2009.01240.x},
  volume       = {137},
  year         = {2009},
}