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Risk of stroke and hormone replacement therapy A prospective cohort study.

Li, Cairu LU ; Engström, Gunnar LU ; Hedblad, Bo LU ; Berglund, Göran LU and Janzon, Lars LU (2006) In Maturitas 54(1). p.41596-41596
Abstract
Objective: The purpose of this study was to examine the fisk of first-ever stroke in relation to use of hormone replacement therapy (HRT) among middle-aged and older Swedish women. Materials: A total of 16,906 women, 45-73 years old, from the 'Diet and Cancer' study in Malmo, Sweden were examined. Women were considered as HRT users if they took systemic hormone therapy regularly. Incidence of stroke was followed for a mean period of 10.5 years. Results: In all, 2148 (12.7%) women used HRT. A total of 461 stroke cases occurred during follow-up, 48 of them in HRT users. Incidence of total stroke and ischemic subtype had no significant relation to HRT use. However, an increased risk of hemorrhagic stroke was found in women taking unopposed... (More)
Objective: The purpose of this study was to examine the fisk of first-ever stroke in relation to use of hormone replacement therapy (HRT) among middle-aged and older Swedish women. Materials: A total of 16,906 women, 45-73 years old, from the 'Diet and Cancer' study in Malmo, Sweden were examined. Women were considered as HRT users if they took systemic hormone therapy regularly. Incidence of stroke was followed for a mean period of 10.5 years. Results: In all, 2148 (12.7%) women used HRT. A total of 461 stroke cases occurred during follow-up, 48 of them in HRT users. Incidence of total stroke and ischemic subtype had no significant relation to HRT use. However, an increased risk of hemorrhagic stroke was found in women taking unopposed estrogen (RR=2.55, 95%CI: 1.03-6.35) or un-native estrogen regimens (RR = 4.27, 95%CI: 1.71-10.66). Although not significantly, the risk of stroke was 33% lower in women who started their treatment before menopause. Among HRT users, the fisk of stroke was associated with advancing age, smoking, excess body weight and hypertension. Conclusions: There is no significant association between hormone therapy and risk of total stroke in women during 10.5 years follow-up. Preparations of estrogen and time for initiation of treatment may affect the risk of stroke. (c) 2005 Elsevier Ireland Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
HRT, prescribing pattern, estrogen components, stroke
in
Maturitas
volume
54
issue
1
pages
41596 - 41596
publisher
Elsevier
external identifiers
  • pmid:16321486
  • wos:000236838300002
  • scopus:33645104304
ISSN
1873-4111
DOI
10.1016/j.maturitas.2005.10.002
language
English
LU publication?
yes
id
0f892b2c-f4c8-4ef1-b067-3b8617437241 (old id 149003)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16321486&dopt=Abstract
date added to LUP
2016-04-01 12:25:48
date last changed
2019-11-26 03:34:03
@article{0f892b2c-f4c8-4ef1-b067-3b8617437241,
  abstract     = {Objective: The purpose of this study was to examine the fisk of first-ever stroke in relation to use of hormone replacement therapy (HRT) among middle-aged and older Swedish women. Materials: A total of 16,906 women, 45-73 years old, from the 'Diet and Cancer' study in Malmo, Sweden were examined. Women were considered as HRT users if they took systemic hormone therapy regularly. Incidence of stroke was followed for a mean period of 10.5 years. Results: In all, 2148 (12.7%) women used HRT. A total of 461 stroke cases occurred during follow-up, 48 of them in HRT users. Incidence of total stroke and ischemic subtype had no significant relation to HRT use. However, an increased risk of hemorrhagic stroke was found in women taking unopposed estrogen (RR=2.55, 95%CI: 1.03-6.35) or un-native estrogen regimens (RR = 4.27, 95%CI: 1.71-10.66). Although not significantly, the risk of stroke was 33% lower in women who started their treatment before menopause. Among HRT users, the fisk of stroke was associated with advancing age, smoking, excess body weight and hypertension. Conclusions: There is no significant association between hormone therapy and risk of total stroke in women during 10.5 years follow-up. Preparations of estrogen and time for initiation of treatment may affect the risk of stroke. (c) 2005 Elsevier Ireland Ltd. All rights reserved.},
  author       = {Li, Cairu and Engström, Gunnar and Hedblad, Bo and Berglund, Göran and Janzon, Lars},
  issn         = {1873-4111},
  language     = {eng},
  number       = {1},
  pages        = {41596--41596},
  publisher    = {Elsevier},
  series       = {Maturitas},
  title        = {Risk of stroke and hormone replacement therapy A prospective cohort study.},
  url          = {http://dx.doi.org/10.1016/j.maturitas.2005.10.002},
  doi          = {10.1016/j.maturitas.2005.10.002},
  volume       = {54},
  year         = {2006},
}