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Periarticular tissue levels of cytokine- and endothelin-1-like immunoreactivity during the course of antigen-induced arthritis in the rat

Andersson, Sven LU ; Lexmuller, K ; Alving, K and Ekstrom, G M (1999) In Inflammation Research 48(9). p.491-496
Abstract
OBJECTIVE AND DESIGN: To correlate the changes in periarticular tissue levels of pro-inflammatory cytokines and endothelin-1 (ET-1) to local pathophysiology in rats with antigen-induced arthritis (AIA). MATERIALS: The periarticular soft tissue was excised from sixty-six rats at different stages of AIA. METHODS: The samples were homogenized and the levels of immune like (LI) reactivities were determined. The levels in the arthritic joints were compared to those in non-arthritic tissue. Statistical significance was determined by ANOVA followed by Fisher PLSD. RESULTS: Compatible with a role in an early alarm reaction some mediators (tumor necrosis factor alpha-LI, interleukin-2-LI and interferon-gamma-LI) were elevated prior to the vascular... (More)
OBJECTIVE AND DESIGN: To correlate the changes in periarticular tissue levels of pro-inflammatory cytokines and endothelin-1 (ET-1) to local pathophysiology in rats with antigen-induced arthritis (AIA). MATERIALS: The periarticular soft tissue was excised from sixty-six rats at different stages of AIA. METHODS: The samples were homogenized and the levels of immune like (LI) reactivities were determined. The levels in the arthritic joints were compared to those in non-arthritic tissue. Statistical significance was determined by ANOVA followed by Fisher PLSD. RESULTS: Compatible with a role in an early alarm reaction some mediators (tumor necrosis factor alpha-LI, interleukin-2-LI and interferon-gamma-LI) were elevated prior to the vascular inflammatory activity. The curve for ET-1-LI closely followed the intensity of the inflammation whereas these parameters preceeded the elevation of interleukin-1beta-LI. CONCLUSIONS: Transient waves of different mediators appear during the course of the arthritis. This indicates the presence of active downregulatory mechanisms. Here the model could differ from human rheumatoid arthritis. (Less)
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author
; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Arthritis, Cytokine, Endothelin, Pannus, Rat
in
Inflammation Research
volume
48
issue
9
pages
491 - 496
publisher
Birkhäuser Verlag
external identifiers
  • pmid:10522804
  • scopus:0032842292
  • pmid:10522804
ISSN
1420-908X
DOI
10.1007/s000110050492
language
English
LU publication?
no
id
0fa9997b-1c30-4bf0-bd68-2eaa8e7686e7 (old id 1116048)
date added to LUP
2016-04-01 12:19:44
date last changed
2022-01-27 02:07:17
@article{0fa9997b-1c30-4bf0-bd68-2eaa8e7686e7,
  abstract     = {{OBJECTIVE AND DESIGN: To correlate the changes in periarticular tissue levels of pro-inflammatory cytokines and endothelin-1 (ET-1) to local pathophysiology in rats with antigen-induced arthritis (AIA). MATERIALS: The periarticular soft tissue was excised from sixty-six rats at different stages of AIA. METHODS: The samples were homogenized and the levels of immune like (LI) reactivities were determined. The levels in the arthritic joints were compared to those in non-arthritic tissue. Statistical significance was determined by ANOVA followed by Fisher PLSD. RESULTS: Compatible with a role in an early alarm reaction some mediators (tumor necrosis factor alpha-LI, interleukin-2-LI and interferon-gamma-LI) were elevated prior to the vascular inflammatory activity. The curve for ET-1-LI closely followed the intensity of the inflammation whereas these parameters preceeded the elevation of interleukin-1beta-LI. CONCLUSIONS: Transient waves of different mediators appear during the course of the arthritis. This indicates the presence of active downregulatory mechanisms. Here the model could differ from human rheumatoid arthritis.}},
  author       = {{Andersson, Sven and Lexmuller, K and Alving, K and Ekstrom, G M}},
  issn         = {{1420-908X}},
  keywords     = {{Arthritis; Cytokine; Endothelin; Pannus; Rat}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{491--496}},
  publisher    = {{Birkhäuser Verlag}},
  series       = {{Inflammation Research}},
  title        = {{Periarticular tissue levels of cytokine- and endothelin-1-like immunoreactivity during the course of antigen-induced arthritis in the rat}},
  url          = {{http://dx.doi.org/10.1007/s000110050492}},
  doi          = {{10.1007/s000110050492}},
  volume       = {{48}},
  year         = {{1999}},
}