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Low-Dose Oral Ketamine for Procedural Analgesia in Pediatric Cancer Patients Undergoing Lumbar Puncture at a Resource-Limited Cancer Hospital in India

Rayala, Spandana ; Bäckdahl, Tim ; Reddy, Naresh ; Jacob, Jean ; Gebre-Medhin, Erik LU ; Karonen, Emil ; Palat, Gayatri ; Sinha, Sudha ; Schyman, Tommy and Wiebe, Thomas LU , et al. (2019) In Journal of Palliative Medicine 22(11). p.1357-1363
Abstract


Aim:
The aim of this study was to evaluate the therapeutic efficacy and safety profile of orally administered low-dose ketamine for procedural pain management in pediatric cancer patients undergoing lumbar puncture (LP) in a resource-limited hospital setting.
Methods:
Patients between 4 and 15 years of age, with leukemia, undergoing LP were asked to participate. The study was designed as a two-armed blinded placebo-controlled trial where 0.8 mg/kg (bodyweight) of ketamine mixed in juice was given 30 minutes before the procedure to Group K (ketamine) compared with placebo, only juice, to Group P (placebo). In addition, topical analgesia (EMLA®) was given according to established standard of care. Patients and... (More)


Aim:
The aim of this study was to evaluate the therapeutic efficacy and safety profile of orally administered low-dose ketamine for procedural pain management in pediatric cancer patients undergoing lumbar puncture (LP) in a resource-limited hospital setting.
Methods:
Patients between 4 and 15 years of age, with leukemia, undergoing LP were asked to participate. The study was designed as a two-armed blinded placebo-controlled trial where 0.8 mg/kg (bodyweight) of ketamine mixed in juice was given 30 minutes before the procedure to Group K (ketamine) compared with placebo, only juice, to Group P (placebo). In addition, topical analgesia (EMLA®) was given according to established standard of care. Patients and caregivers assessed the pain using the Wong-Baker Faces Pain Rating Scale.
Results:
A total number of 52 patients, equally distributed between Group K and Group P, were included in the study. The placebo-controlled group had significantly higher self-reported pain score than the group receiving ketamine (p = 0.046), as well as in caregiver-assessed pain (p = 0.033). Only three incidents of mild adverse effects were reported.
Conclusion:
Low-dose oral ketamine can be safely administered for procedural analgesia in pediatric cancer patients undergoing LP in a resource-limited hospital setting and have significant pain-reducing effect compared with placebo.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Palliative Medicine
volume
22
issue
11
pages
1357 - 1363
publisher
Mary Ann Liebert, Inc.
external identifiers
  • scopus:85073513066
  • pmid:31090488
ISSN
1096-6218
DOI
10.1089/jpm.2018.0667
language
English
LU publication?
yes
id
0fb14a9f-7d00-4204-ae59-44120da41ce0
date added to LUP
2019-07-01 13:54:08
date last changed
2024-05-28 19:43:18
@article{0fb14a9f-7d00-4204-ae59-44120da41ce0,
  abstract     = {{<p><br>
 Aim:<br>
 The aim of this study was to evaluate the therapeutic efficacy and safety profile of orally administered low-dose ketamine for procedural pain management in pediatric cancer patients undergoing lumbar puncture (LP) in a resource-limited hospital setting. <br>
 Methods:<br>
 Patients between 4 and 15 years of age, with leukemia, undergoing LP were asked to participate. The study was designed as a two-armed blinded placebo-controlled trial where 0.8 mg/kg (bodyweight) of ketamine mixed in juice was given 30 minutes before the procedure to Group K (ketamine) compared with placebo, only juice, to Group P (placebo). In addition, topical analgesia (EMLA®) was given according to established standard of care. Patients and caregivers assessed the pain using the Wong-Baker Faces Pain Rating Scale. <br>
 Results:<br>
 A total number of 52 patients, equally distributed between Group K and Group P, were included in the study. The placebo-controlled group had significantly higher self-reported pain score than the group receiving ketamine (p = 0.046), as well as in caregiver-assessed pain (p = 0.033). Only three incidents of mild adverse effects were reported. <br>
 Conclusion:<br>
 Low-dose oral ketamine can be safely administered for procedural analgesia in pediatric cancer patients undergoing LP in a resource-limited hospital setting and have significant pain-reducing effect compared with placebo.</p>}},
  author       = {{Rayala, Spandana and Bäckdahl, Tim and Reddy, Naresh and Jacob, Jean and Gebre-Medhin, Erik and Karonen, Emil and Palat, Gayatri and Sinha, Sudha and Schyman, Tommy and Wiebe, Thomas and Brun, Eva and Segerlantz, Mikael}},
  issn         = {{1096-6218}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{11}},
  pages        = {{1357--1363}},
  publisher    = {{Mary Ann Liebert, Inc.}},
  series       = {{Journal of Palliative Medicine}},
  title        = {{Low-Dose Oral Ketamine for Procedural Analgesia in Pediatric Cancer Patients Undergoing Lumbar Puncture at a Resource-Limited Cancer Hospital in India}},
  url          = {{http://dx.doi.org/10.1089/jpm.2018.0667}},
  doi          = {{10.1089/jpm.2018.0667}},
  volume       = {{22}},
  year         = {{2019}},
}