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Is CGRP a marker for chronic migraine?

Silberstein, Stephen D and Edvinsson, Lars LU (2013) In Neurology
Abstract
Calcitonin gene-related peptide (CGRP) research was initiated by Poyner et al.,(1) who found that the calcitonin gene encodes the 37-amino acid neuropeptide CGRP in neuronal tissue. Within months, the Lund group produced antibodies toward α-CGRP and developed sensitive methods to study the role of this peptide in the cranial circulation. Intracranial vessels and the trigeminal ganglion harbor this potent vasodilator peptide.(2) Functionally, CGRP has a substantial role in the trigeminovascular reflex.(3) The calcitonin family is now well-characterized and contains 6 members: calcitonin, amylin, adenomedullin-2, adrenomedullin, and CGRP (2 isoforms: α-CGRP and β-CGRP).(4) The α- and β-isoforms of CGRP are similar in their biological... (More)
Calcitonin gene-related peptide (CGRP) research was initiated by Poyner et al.,(1) who found that the calcitonin gene encodes the 37-amino acid neuropeptide CGRP in neuronal tissue. Within months, the Lund group produced antibodies toward α-CGRP and developed sensitive methods to study the role of this peptide in the cranial circulation. Intracranial vessels and the trigeminal ganglion harbor this potent vasodilator peptide.(2) Functionally, CGRP has a substantial role in the trigeminovascular reflex.(3) The calcitonin family is now well-characterized and contains 6 members: calcitonin, amylin, adenomedullin-2, adrenomedullin, and CGRP (2 isoforms: α-CGRP and β-CGRP).(4) The α- and β-isoforms of CGRP are similar in their biological activities but show different tissue distributions. β-CGRP is mainly found in enteric nerves and in the pituitary gland, while α-CGRP is found predominantly in sensory neurons and in the CNS.(5) CGRP causes cranial vasodilatation and facilitates nociception. During a migraine attack, trigeminal activation results in the release of CGRP from presynaptic nerve terminals and induces vasodilatation and neurogenic inflammation in leptomeningeal and extracranial vessels, which gives rise to the typical throbbing pain of migraine. Goadsby and Edvinsson(6) showed that plasma concentrations of CGRP are elevated in the external jugular venous blood during migraine headaches and that sumatriptan can abort the rise in CGRP and the headache.(4) CGRP given IV causes headache only in migraine patients and CGRP antagonists are effective for the acute treatment of migraine.(7) Until now, CGRP elevation in the plasma has not been reproduced in all studies.(8) However, technical problems have sometimes hampered the proper measurements of CGRP.(9.) (Less)
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Contribution to journal
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published
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Neurology
publisher
American Academy of Neurology
external identifiers
  • pmid:23975870
  • scopus:84888321527
ISSN
1526-632X
DOI
10.1212/WNL.0b013e3182a6cc33
language
English
LU publication?
yes
id
0ff44f12-e0da-4d90-81ee-44d7ff5b7c4a (old id 4005362)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23975870?dopt=Abstract
date added to LUP
2013-09-05 13:20:40
date last changed
2019-07-30 02:48:17
@article{0ff44f12-e0da-4d90-81ee-44d7ff5b7c4a,
  abstract     = {Calcitonin gene-related peptide (CGRP) research was initiated by Poyner et al.,(1) who found that the calcitonin gene encodes the 37-amino acid neuropeptide CGRP in neuronal tissue. Within months, the Lund group produced antibodies toward α-CGRP and developed sensitive methods to study the role of this peptide in the cranial circulation. Intracranial vessels and the trigeminal ganglion harbor this potent vasodilator peptide.(2) Functionally, CGRP has a substantial role in the trigeminovascular reflex.(3) The calcitonin family is now well-characterized and contains 6 members: calcitonin, amylin, adenomedullin-2, adrenomedullin, and CGRP (2 isoforms: α-CGRP and β-CGRP).(4) The α- and β-isoforms of CGRP are similar in their biological activities but show different tissue distributions. β-CGRP is mainly found in enteric nerves and in the pituitary gland, while α-CGRP is found predominantly in sensory neurons and in the CNS.(5) CGRP causes cranial vasodilatation and facilitates nociception. During a migraine attack, trigeminal activation results in the release of CGRP from presynaptic nerve terminals and induces vasodilatation and neurogenic inflammation in leptomeningeal and extracranial vessels, which gives rise to the typical throbbing pain of migraine. Goadsby and Edvinsson(6) showed that plasma concentrations of CGRP are elevated in the external jugular venous blood during migraine headaches and that sumatriptan can abort the rise in CGRP and the headache.(4) CGRP given IV causes headache only in migraine patients and CGRP antagonists are effective for the acute treatment of migraine.(7) Until now, CGRP elevation in the plasma has not been reproduced in all studies.(8) However, technical problems have sometimes hampered the proper measurements of CGRP.(9.)},
  author       = {Silberstein, Stephen D and Edvinsson, Lars},
  issn         = {1526-632X},
  language     = {eng},
  month        = {08},
  publisher    = {American Academy of Neurology},
  series       = {Neurology},
  title        = {Is CGRP a marker for chronic migraine?},
  url          = {http://dx.doi.org/10.1212/WNL.0b013e3182a6cc33},
  year         = {2013},
}