Selective molecular adsorption using electrospun nanofiber affinity membranes.
Yoshimatsu, Keiichi LU ; Ye, Lei LU
; Lindberg, Johanna
and Chronakis, Ioannis S
(2008)
In Biosensors & Bioelectronics
23(7).
p.1208-1215
- Abstract
- Molecularly imprinted nanoparticles were encapsulated into polymer nanofibers with a simple electrospinning method. The composite nanofibers form non-woven mats that can be used as affinity membrane to greatly simplify solid phase extraction of drug residues in analytical samples. Upward 100% of propranolol-imprinted nanoparticles can be easily encapsulated into poly(ethylene terephthalate) nanofibers, ensuring the composite materials to have a high specific binding capacity. As confirmed by radioligand binding analysis, the specific binding sites in the composite materials remain easily accessible and are chiral-selective. Using the new composite nanofiber mats as solid phase extraction materials, trace amount of propranolol (1ngmL(-1))... (More)
- Molecularly imprinted nanoparticles were encapsulated into polymer nanofibers with a simple electrospinning method. The composite nanofibers form non-woven mats that can be used as affinity membrane to greatly simplify solid phase extraction of drug residues in analytical samples. Upward 100% of propranolol-imprinted nanoparticles can be easily encapsulated into poly(ethylene terephthalate) nanofibers, ensuring the composite materials to have a high specific binding capacity. As confirmed by radioligand binding analysis, the specific binding sites in the composite materials remain easily accessible and are chiral-selective. Using the new composite nanofiber mats as solid phase extraction materials, trace amount of propranolol (1ngmL(-1)) in tap water can be easily detected after a simple sample preparation. As validated in this study, there is no problem of template leakage from the composite nanofibers. Without the solid phase extraction, the existence of propranolol residues in water cannot be confirmed with even tandem HPLC-MS/MS analysis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1021011
- author
- Yoshimatsu, Keiichi
LU
; Ye, Lei
LU
; Lindberg, Johanna
and Chronakis, Ioannis S
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Biosensors & Bioelectronics
- volume
- 23
- issue
- 7
- pages
- 1208 - 1215
- publisher
- Elsevier
- external identifiers
-
- pmid:18226521
- wos:000253620900042
- scopus:38749122433
- pmid:18226521
- ISSN
- 1873-4235
- DOI
- 10.1016/j.bios.2007.12.002
- language
- English
- LU publication?
- yes
- id
- 7123f01e-a027-410b-8314-135f0bc0d3da (old id 1021011)
- date added to LUP
- 2016-04-01 14:56:37
- date last changed
- 2025-02-01 12:37:00
@article{7123f01e-a027-410b-8314-135f0bc0d3da,
abstract = {{Molecularly imprinted nanoparticles were encapsulated into polymer nanofibers with a simple electrospinning method. The composite nanofibers form non-woven mats that can be used as affinity membrane to greatly simplify solid phase extraction of drug residues in analytical samples. Upward 100% of propranolol-imprinted nanoparticles can be easily encapsulated into poly(ethylene terephthalate) nanofibers, ensuring the composite materials to have a high specific binding capacity. As confirmed by radioligand binding analysis, the specific binding sites in the composite materials remain easily accessible and are chiral-selective. Using the new composite nanofiber mats as solid phase extraction materials, trace amount of propranolol (1ngmL(-1)) in tap water can be easily detected after a simple sample preparation. As validated in this study, there is no problem of template leakage from the composite nanofibers. Without the solid phase extraction, the existence of propranolol residues in water cannot be confirmed with even tandem HPLC-MS/MS analysis.}},
author = {{Yoshimatsu, Keiichi and Ye, Lei and Lindberg, Johanna and Chronakis, Ioannis S}},
issn = {{1873-4235}},
language = {{eng}},
number = {{7}},
pages = {{1208--1215}},
publisher = {{Elsevier}},
series = {{Biosensors & Bioelectronics}},
title = {{Selective molecular adsorption using electrospun nanofiber affinity membranes.}},
url = {{http://dx.doi.org/10.1016/j.bios.2007.12.002}},
doi = {{10.1016/j.bios.2007.12.002}},
volume = {{23}},
year = {{2008}},
}