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Treatment of migraine attacks based on the interaction with the trigemino-cerebrovascular system.

Link, Andrea; Kuris, Aniko LU and Edvinsson, Lars LU (2008) In Journal of Headache and Pain 9.
Abstract
Primary headaches such as migraine are among the most prevalent neurological disorders, affecting up to one-fifth of the adult population. The scientific work in the last decade has unraveled much of the pathophysiological background of migraine, which is now considered to be a neurovascular disorder. It has been discovered that the trigemino-cerebrovascular system plays a key role in migraine headache pathophysiology by releasing the potent vasodilator calcitonin gene-related peptide (CGRP). This neuropeptide is released in parallel with the pain and its concentration correlates well with the intensity of the headache. The development of drugs of the triptan class has provided relief for the acute attacks but at the cost of, mainly... (More)
Primary headaches such as migraine are among the most prevalent neurological disorders, affecting up to one-fifth of the adult population. The scientific work in the last decade has unraveled much of the pathophysiological background of migraine, which is now considered to be a neurovascular disorder. It has been discovered that the trigemino-cerebrovascular system plays a key role in migraine headache pathophysiology by releasing the potent vasodilator calcitonin gene-related peptide (CGRP). This neuropeptide is released in parallel with the pain and its concentration correlates well with the intensity of the headache. The development of drugs of the triptan class has provided relief for the acute attacks but at the cost of, mainly cardiovascular, side effects. Thus, the intention to improve treatment led to the development of small CGRP receptor antagonists such as olcegepant (BIBN4096BS) and MK-0974 that alleviate the acute migraine attack without acute side events. The purpose of this review is to give a short overview of the pathological background of migraine headache and to illustrate the mechanisms behind the actions of triptans and the promising CGRP receptor blockers. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Trigemino-cerebrovascular system, Olcegepant, Triptan, CGRP
in
Journal of Headache and Pain
volume
9
publisher
Springer
external identifiers
  • pmid:18217201
  • wos:000260104900003
  • scopus:39549094684
ISSN
1129-2369
DOI
10.1007/s10194-008-0011-4
language
English
LU publication?
yes
id
ad1a30d7-21fe-4c71-968a-92cb06759d07 (old id 1021142)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18217201?dopt=Abstract
date added to LUP
2008-02-12 13:29:34
date last changed
2017-10-01 03:57:01
@article{ad1a30d7-21fe-4c71-968a-92cb06759d07,
  abstract     = {Primary headaches such as migraine are among the most prevalent neurological disorders, affecting up to one-fifth of the adult population. The scientific work in the last decade has unraveled much of the pathophysiological background of migraine, which is now considered to be a neurovascular disorder. It has been discovered that the trigemino-cerebrovascular system plays a key role in migraine headache pathophysiology by releasing the potent vasodilator calcitonin gene-related peptide (CGRP). This neuropeptide is released in parallel with the pain and its concentration correlates well with the intensity of the headache. The development of drugs of the triptan class has provided relief for the acute attacks but at the cost of, mainly cardiovascular, side effects. Thus, the intention to improve treatment led to the development of small CGRP receptor antagonists such as olcegepant (BIBN4096BS) and MK-0974 that alleviate the acute migraine attack without acute side events. The purpose of this review is to give a short overview of the pathological background of migraine headache and to illustrate the mechanisms behind the actions of triptans and the promising CGRP receptor blockers.},
  articleno    = {41406},
  author       = {Link, Andrea and Kuris, Aniko and Edvinsson, Lars},
  issn         = {1129-2369},
  keyword      = {Trigemino-cerebrovascular system,Olcegepant,Triptan,CGRP},
  language     = {eng},
  publisher    = {Springer},
  series       = {Journal of Headache and Pain},
  title        = {Treatment of migraine attacks based on the interaction with the trigemino-cerebrovascular system.},
  url          = {http://dx.doi.org/10.1007/s10194-008-0011-4},
  volume       = {9},
  year         = {2008},
}