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Impact of different topical negative pressure levels on myocardial microvascular blood flow.

Lindstedt Ingemansson, Sandra LU ; Malmsjö, Malin LU ; Sjögren, Johan LU ; Gustafsson, Ronny LU and Ingemansson, Richard LU (2008) In Cardiovascular Revascularization Medicine 9(1). p.29-35
Abstract
BACKGROUND: We have previously shown that a myocardial topical negative pressure (TNP) of -50 mmHg significantly increases microvascular blood flow in the underlying myocardium in normal, ischemic, and reperfused porcine myocardium. The present study was designed to elucidate the effect of different TNP levels between -50 and -150 mmHg on microvascular flow in normal and ischemic myocardium. MATERIALS AND METHODS: Seven pigs underwent median sternotomy. The microvascular blood flow in the myocardium was recorded, before and after the application of TNP, using laser Doppler velocimetry. Analyses were performed before left anterior descending artery (LAD) occlusion (normal myocardium) and after 20 min of LAD occlusion (ischemic myocardium).... (More)
BACKGROUND: We have previously shown that a myocardial topical negative pressure (TNP) of -50 mmHg significantly increases microvascular blood flow in the underlying myocardium in normal, ischemic, and reperfused porcine myocardium. The present study was designed to elucidate the effect of different TNP levels between -50 and -150 mmHg on microvascular flow in normal and ischemic myocardium. MATERIALS AND METHODS: Seven pigs underwent median sternotomy. The microvascular blood flow in the myocardium was recorded, before and after the application of TNP, using laser Doppler velocimetry. Analyses were performed before left anterior descending artery (LAD) occlusion (normal myocardium) and after 20 min of LAD occlusion (ischemic myocardium). RESULTS: A TNP of -50 mmHg significantly increased microvascular blood flow in both normal (from 320.0+/-56.1 PU before TNP application to 435.7+/-65.5 PU after TNP application, P=.028) and ischemic myocardium (from 110.0+/-36.7 PU before TNP application to 194.3+/-56.2 PU after TNP application, P=.012). TNP between -75 and -150 mmHg showed no significant increase in microvascular blood flow in normal or ischemic myocardium. CONCLUSIONS: Of pressures between -50 and -150 mmHg, a TNP of -50 mmHg seems to be the most effective negative pressure concerning significant increase in microvascular blood flow in both normal and ischemic myocardium. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cardiovascular Revascularization Medicine
volume
9
issue
1
pages
29 - 35
publisher
Elsevier Inc.
external identifiers
  • pmid:18206635
  • scopus:38149116064
ISSN
1878-0938
DOI
10.1016/j.carrev.2007.09.001
language
English
LU publication?
yes
id
b98f0b7e-149e-439e-83e8-75442b6ac1a2 (old id 1021246)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18206635?dopt=Abstract
date added to LUP
2008-02-12 13:26:52
date last changed
2017-08-06 04:43:40
@article{b98f0b7e-149e-439e-83e8-75442b6ac1a2,
  abstract     = {BACKGROUND: We have previously shown that a myocardial topical negative pressure (TNP) of -50 mmHg significantly increases microvascular blood flow in the underlying myocardium in normal, ischemic, and reperfused porcine myocardium. The present study was designed to elucidate the effect of different TNP levels between -50 and -150 mmHg on microvascular flow in normal and ischemic myocardium. MATERIALS AND METHODS: Seven pigs underwent median sternotomy. The microvascular blood flow in the myocardium was recorded, before and after the application of TNP, using laser Doppler velocimetry. Analyses were performed before left anterior descending artery (LAD) occlusion (normal myocardium) and after 20 min of LAD occlusion (ischemic myocardium). RESULTS: A TNP of -50 mmHg significantly increased microvascular blood flow in both normal (from 320.0+/-56.1 PU before TNP application to 435.7+/-65.5 PU after TNP application, P=.028) and ischemic myocardium (from 110.0+/-36.7 PU before TNP application to 194.3+/-56.2 PU after TNP application, P=.012). TNP between -75 and -150 mmHg showed no significant increase in microvascular blood flow in normal or ischemic myocardium. CONCLUSIONS: Of pressures between -50 and -150 mmHg, a TNP of -50 mmHg seems to be the most effective negative pressure concerning significant increase in microvascular blood flow in both normal and ischemic myocardium.},
  author       = {Lindstedt Ingemansson, Sandra and Malmsjö, Malin and Sjögren, Johan and Gustafsson, Ronny and Ingemansson, Richard},
  issn         = {1878-0938},
  language     = {eng},
  number       = {1},
  pages        = {29--35},
  publisher    = {Elsevier Inc.},
  series       = {Cardiovascular Revascularization Medicine},
  title        = {Impact of different topical negative pressure levels on myocardial microvascular blood flow.},
  url          = {http://dx.doi.org/10.1016/j.carrev.2007.09.001},
  volume       = {9},
  year         = {2008},
}