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High NT-proBNP Is a Strong Predictor of Outcome in Elderly Heart Failure Patients.

Andersson, Sven E; Edvinsson, Marie-Louise; Björk, Jonas LU and Edvinsson, Lars LU (2008) In American Journal of Geriatric Cardiology 17(1). p.13-20
Abstract
All patients older than 65 years (184 men; mean age, 78+/-0.8 years/181 women; mean age, 82+/-0.6 years) seeking medical attention at the Lund University Hospital Emergency Clinic during a 2-year period who had an N-terminal prohormone brain natriuretic peptide (NT-proBNP) value >2000 pg/mL were followed up for survival. Mortality in the entire population was 21% after 3 months, 35% after 1 year, and 40% after 2 years. Multivariate analysis indicated that the NT-proBNP level and the New York Heart Association (NYHA) functional class were stronger predictors of mortality than were echocardiographic estimation of left ventricular ejection fraction or chest radiography. Patients who survived the first year were younger, had higher systolic... (More)
All patients older than 65 years (184 men; mean age, 78+/-0.8 years/181 women; mean age, 82+/-0.6 years) seeking medical attention at the Lund University Hospital Emergency Clinic during a 2-year period who had an N-terminal prohormone brain natriuretic peptide (NT-proBNP) value >2000 pg/mL were followed up for survival. Mortality in the entire population was 21% after 3 months, 35% after 1 year, and 40% after 2 years. Multivariate analysis indicated that the NT-proBNP level and the New York Heart Association (NYHA) functional class were stronger predictors of mortality than were echocardiographic estimation of left ventricular ejection fraction or chest radiography. Patients who survived the first year were younger, had higher systolic blood pressure, had lower plasma creatinine, had lower inflammatory activity, and were treated with lower doses of furosemide. The results indicate that in this population, NT-proBNP level together with assessment of NYHA class gives the best prognostic information of 1-year mortality. (Am J Geriatr Cardiol. 2008;17:13-20). (Less)
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type
Contribution to journal
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published
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in
American Journal of Geriatric Cardiology
volume
17
issue
1
pages
13 - 20
publisher
John Wiley & Sons
external identifiers
  • pmid:18174755
  • wos:000252512100003
  • scopus:40949124881
ISSN
1751-715X
language
English
LU publication?
yes
id
085a158e-cc5f-4328-85cc-7838d9a8e1c2 (old id 1021627)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18174755?dopt=Abstract
date added to LUP
2008-02-07 12:46:15
date last changed
2017-01-01 07:40:22
@article{085a158e-cc5f-4328-85cc-7838d9a8e1c2,
  abstract     = {All patients older than 65 years (184 men; mean age, 78+/-0.8 years/181 women; mean age, 82+/-0.6 years) seeking medical attention at the Lund University Hospital Emergency Clinic during a 2-year period who had an N-terminal prohormone brain natriuretic peptide (NT-proBNP) value >2000 pg/mL were followed up for survival. Mortality in the entire population was 21% after 3 months, 35% after 1 year, and 40% after 2 years. Multivariate analysis indicated that the NT-proBNP level and the New York Heart Association (NYHA) functional class were stronger predictors of mortality than were echocardiographic estimation of left ventricular ejection fraction or chest radiography. Patients who survived the first year were younger, had higher systolic blood pressure, had lower plasma creatinine, had lower inflammatory activity, and were treated with lower doses of furosemide. The results indicate that in this population, NT-proBNP level together with assessment of NYHA class gives the best prognostic information of 1-year mortality. (Am J Geriatr Cardiol. 2008;17:13-20).},
  author       = {Andersson, Sven E and Edvinsson, Marie-Louise and Björk, Jonas and Edvinsson, Lars},
  issn         = {1751-715X},
  language     = {eng},
  number       = {1},
  pages        = {13--20},
  publisher    = {John Wiley & Sons},
  series       = {American Journal of Geriatric Cardiology},
  title        = {High NT-proBNP Is a Strong Predictor of Outcome in Elderly Heart Failure Patients.},
  volume       = {17},
  year         = {2008},
}