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Intracerebral grafting of neuronal cell suspensions. IV. Behavioural recovery in rats with unilateral implants of nigral cell suspensions in different forebrain sites

Dunnett, S B; Björklund, Anders LU ; Schmidt, R H; Stenevi, U and Iversen, S D (1983) In Acta Physiologica Scandinavica1888-12-31+01:002006-01-01+01:00 Suppl. 522. p.29-38
Abstract
Single and multiple implants of nigral cell suspensions were grafted to the forebrains of rats with unilateral 6-hydroxydopamine-induced dopamine denervations. Control lesions alone induced a marked behavioural asymmetry, as assessed by amphetamine- and apomorphine-induced rotation, sensorimotor tests and side bias in an unbaited T-maze, and the animals were hyperactive to a low dose of apomorphine. Single suspension placements into different denervated striatal regions were capable of reversing the behavioural asymmetries dependent upon the specific placement for each test. Multiple suspension grafts were capable of reversing all behavioural asymmetries, and additionally abolished the supersensitive hyperactivity to apomorphine. By... (More)
Single and multiple implants of nigral cell suspensions were grafted to the forebrains of rats with unilateral 6-hydroxydopamine-induced dopamine denervations. Control lesions alone induced a marked behavioural asymmetry, as assessed by amphetamine- and apomorphine-induced rotation, sensorimotor tests and side bias in an unbaited T-maze, and the animals were hyperactive to a low dose of apomorphine. Single suspension placements into different denervated striatal regions were capable of reversing the behavioural asymmetries dependent upon the specific placement for each test. Multiple suspension grafts were capable of reversing all behavioural asymmetries, and additionally abolished the supersensitive hyperactivity to apomorphine. By contrast, single suspension grafts placed into the substantia nigra or lateral hypothalamus had no detectable effect on any functional measure. The results indicate that nigral suspension grafts can be at least as effective as solid grafts in reversing the functional deficits induced by dopamine denervation, provided that placements are selected within appropriate dopamine terminal regions of the forebrain (e.g. caudate-putamen or nucleus accumbens). (Less)
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Animal*Brain/surgeryCorpus Striatum/drug effectsEmbryo, AnimalsBehavior, Isogeneic, Mammalian/cytologyFemaleHydroxydopaminesNeurons/transplantation*OxidopamineRatsRats, Inbred StrainsSubstantia Nigra/drug effectsSubstantia Nigra/transplantation*Transplantation
in
Acta Physiologica Scandinavica1888-12-31+01:002006-01-01+01:00
volume
Suppl. 522
pages
29 - 38
publisher
Wiley-Blackwell
language
English
LU publication?
yes
id
189a03f5-5997-4c1d-90c7-3c5f6b0ec9de (old id 1030567)
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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6426250dopt=Abstract
date added to LUP
2008-02-11 13:30:07
date last changed
2018-05-29 09:27:51
@article{189a03f5-5997-4c1d-90c7-3c5f6b0ec9de,
  abstract     = {Single and multiple implants of nigral cell suspensions were grafted to the forebrains of rats with unilateral 6-hydroxydopamine-induced dopamine denervations. Control lesions alone induced a marked behavioural asymmetry, as assessed by amphetamine- and apomorphine-induced rotation, sensorimotor tests and side bias in an unbaited T-maze, and the animals were hyperactive to a low dose of apomorphine. Single suspension placements into different denervated striatal regions were capable of reversing the behavioural asymmetries dependent upon the specific placement for each test. Multiple suspension grafts were capable of reversing all behavioural asymmetries, and additionally abolished the supersensitive hyperactivity to apomorphine. By contrast, single suspension grafts placed into the substantia nigra or lateral hypothalamus had no detectable effect on any functional measure. The results indicate that nigral suspension grafts can be at least as effective as solid grafts in reversing the functional deficits induced by dopamine denervation, provided that placements are selected within appropriate dopamine terminal regions of the forebrain (e.g. caudate-putamen or nucleus accumbens).},
  author       = {Dunnett, S B and Björklund, Anders and Schmidt, R H and Stenevi, U and Iversen, S D},
  keyword      = {Animal*Brain/surgeryCorpus Striatum/drug effectsEmbryo,AnimalsBehavior,Isogeneic,Mammalian/cytologyFemaleHydroxydopaminesNeurons/transplantation*OxidopamineRatsRats,Inbred StrainsSubstantia Nigra/drug effectsSubstantia Nigra/transplantation*Transplantation},
  language     = {eng},
  pages        = {29--38},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Physiologica Scandinavica1888-12-31+01:002006-01-01+01:00},
  title        = {Intracerebral grafting of neuronal cell suspensions. IV. Behavioural recovery in rats with unilateral implants of nigral cell suspensions in different forebrain sites},
  volume       = {Suppl. 522},
  year         = {1983},
}