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Comparison of three methods to find the vapor activity of a hydration step

Wadsö, Lars LU and Markova, N (2001) In European Journal of Pharmaceutics and Biopharmaceutics 51(1). p.77-81
Abstract
The formation of a stochiometric salt hydrate takes place at a well defined vapor activity. We have compared three methods to measure this vapor activity. In two of the methods we used a sorption balance in step mode and in ramp mode, respectively, and in one method we used a newly developed sorption microcalorimeter. The tests were made with the formation of morphine sulphate pentahydrate from its dihydrate at 25°C. With all three methods this transition was found to take place at a vapor activity close to 0.21.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Pharmaceutics and Biopharmaceutics
volume
51
issue
1
pages
77 - 81
publisher
Elsevier
external identifiers
  • scopus:0035168377
ISSN
0939-6411
DOI
10.1016/S0939-6411(00)00134-X
language
English
LU publication?
yes
id
e93584dc-ecac-4e02-81f9-c741532e292b (old id 1034515)
date added to LUP
2008-02-19 09:21:05
date last changed
2018-01-07 06:10:56
@article{e93584dc-ecac-4e02-81f9-c741532e292b,
  abstract     = {The formation of a stochiometric salt hydrate takes place at a well defined vapor activity. We have compared three methods to measure this vapor activity. In two of the methods we used a sorption balance in step mode and in ramp mode, respectively, and in one method we used a newly developed sorption microcalorimeter. The tests were made with the formation of morphine sulphate pentahydrate from its dihydrate at 25°C. With all three methods this transition was found to take place at a vapor activity close to 0.21.},
  author       = {Wadsö, Lars and Markova, N},
  issn         = {0939-6411},
  language     = {eng},
  number       = {1},
  pages        = {77--81},
  publisher    = {Elsevier},
  series       = {European Journal of Pharmaceutics and Biopharmaceutics},
  title        = {Comparison of three methods to find the vapor activity of a hydration step},
  url          = {http://dx.doi.org/10.1016/S0939-6411(00)00134-X},
  volume       = {51},
  year         = {2001},
}