Advanced

Human cerebral blood volume (CBV) measured by dynamic susceptibility contrast MRI and 99mTc-RBC SPECT.

Engvall, Christian; Ryding, Erik LU ; Wirestam, Ronnie LU ; Holtås, Stig LU ; Ljunggren, Kaj LU ; Ohlsson, Tomas G LU and Reinstrup, Peter LU (2008) In Journal of Neurosurgical Anesthesiology 20(1). p.41-44
Abstract
BACKGROUND: Patients with elevated intracranial pressure risk compromising their cerebral blood flow, resulting in ischemia. Lowering of the raised intracranial pressure, is therefore, mandatory. Reduction of the cerebral blood volume (CBV) might be target. In finding ways to do so, one has to be able to measure CBV. Measurement of CBV is, however, difficult. Radio(99mTc-)labeled erythrocytes (99mTcRBC) single photon emission computer-aided tomography (SPECT) is one established method used for CBV measurement. Recently, dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI), has also been successfully used for this purpose. The aim of this study was to validate the use of DSC-MRI for the measurement of CBV by the... (More)
BACKGROUND: Patients with elevated intracranial pressure risk compromising their cerebral blood flow, resulting in ischemia. Lowering of the raised intracranial pressure, is therefore, mandatory. Reduction of the cerebral blood volume (CBV) might be target. In finding ways to do so, one has to be able to measure CBV. Measurement of CBV is, however, difficult. Radio(99mTc-)labeled erythrocytes (99mTcRBC) single photon emission computer-aided tomography (SPECT) is one established method used for CBV measurement. Recently, dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI), has also been successfully used for this purpose. The aim of this study was to validate the use of DSC-MRI for the measurement of CBV by the investigation of the correlation between the regional distributions of 99mTc-RBC SPECT and DSC-MRI measurement of CBV in humans. If possible, the aim was also to find a conversion constant that will enable the DCS-MRI to be interpreted as CBV (percent of brain volume). METHODS: CBV of 8 volunteers were studied under normocapnic and hypocapnic conditions. CBV was measured with both 99mTc-RBC SPECT and DSC-MRI. RESULTS: There were significant correlations between the regional distributions of CBV measured by 99mTc-RBC SPECT and DSC-MRI (rest: F=4.53, P<0.05; hypocapnia: F=9.61, P<0.005). The derived conversion factor between DSC-MRI voxel values and 99mTc-RBC SPECT CBV (percent of brain volume) at rest was 0.0059+/-0.0013. Global CBV during normocapnia was 4.3%+/-0.6% of brain volume as measured by SPECT of brain volume and 4.5%+/-0.9% as measured by MRI. Decreasing the end-tidal pCO2 by 1.8 kPa by spontaneous hyperventilation reduced the global CBV significantly to 3.9%+/-0.5% in the SPECT group and to 3.5%+/-0.6% in the MRI group. CONCLUSIONS: The comparison of 99mTc-RBC SPECT and DSC-MRI measurements in our study indicates that DSC-MRI can be a useful method to measure CBV as a percent of brain volume. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Single-Photon: methods, Emission-Computed, Blood Volume Determination: methods, Blood Volume: physiology, Brain: radionuclide imaging, Carbon Dioxide: blood, Cerebrovascular Circulation: physiology, Erythrocytes: radionuclide imaging, Hyperventilation: metabolism, Hypocapnia: radionuclide imaging, Magnetic Resonance Imaging: methods, Tomography, Technetium: diagnostic use
in
Journal of Neurosurgical Anesthesiology
volume
20
issue
1
pages
41 - 44
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:18157024
  • wos:000252109600007
  • scopus:39049099572
ISSN
1537-1921
DOI
10.1097/ANA.0b013e31815d4c70
language
English
LU publication?
yes
id
387aba6b-c310-4f32-95eb-84eb05cdc8e0 (old id 1034957)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18157024?dopt=Abstract
date added to LUP
2008-03-31 08:50:13
date last changed
2017-02-19 04:24:40
@article{387aba6b-c310-4f32-95eb-84eb05cdc8e0,
  abstract     = {BACKGROUND: Patients with elevated intracranial pressure risk compromising their cerebral blood flow, resulting in ischemia. Lowering of the raised intracranial pressure, is therefore, mandatory. Reduction of the cerebral blood volume (CBV) might be target. In finding ways to do so, one has to be able to measure CBV. Measurement of CBV is, however, difficult. Radio(99mTc-)labeled erythrocytes (99mTcRBC) single photon emission computer-aided tomography (SPECT) is one established method used for CBV measurement. Recently, dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI), has also been successfully used for this purpose. The aim of this study was to validate the use of DSC-MRI for the measurement of CBV by the investigation of the correlation between the regional distributions of 99mTc-RBC SPECT and DSC-MRI measurement of CBV in humans. If possible, the aim was also to find a conversion constant that will enable the DCS-MRI to be interpreted as CBV (percent of brain volume). METHODS: CBV of 8 volunteers were studied under normocapnic and hypocapnic conditions. CBV was measured with both 99mTc-RBC SPECT and DSC-MRI. RESULTS: There were significant correlations between the regional distributions of CBV measured by 99mTc-RBC SPECT and DSC-MRI (rest: F=4.53, P&lt;0.05; hypocapnia: F=9.61, P&lt;0.005). The derived conversion factor between DSC-MRI voxel values and 99mTc-RBC SPECT CBV (percent of brain volume) at rest was 0.0059+/-0.0013. Global CBV during normocapnia was 4.3%+/-0.6% of brain volume as measured by SPECT of brain volume and 4.5%+/-0.9% as measured by MRI. Decreasing the end-tidal pCO2 by 1.8 kPa by spontaneous hyperventilation reduced the global CBV significantly to 3.9%+/-0.5% in the SPECT group and to 3.5%+/-0.6% in the MRI group. CONCLUSIONS: The comparison of 99mTc-RBC SPECT and DSC-MRI measurements in our study indicates that DSC-MRI can be a useful method to measure CBV as a percent of brain volume.},
  author       = {Engvall, Christian and Ryding, Erik and Wirestam, Ronnie and Holtås, Stig and Ljunggren, Kaj and Ohlsson, Tomas G and Reinstrup, Peter},
  issn         = {1537-1921},
  keyword      = {Single-Photon: methods,Emission-Computed,Blood Volume Determination: methods,Blood Volume: physiology,Brain: radionuclide imaging,Carbon Dioxide: blood,Cerebrovascular Circulation: physiology,Erythrocytes: radionuclide imaging,Hyperventilation: metabolism,Hypocapnia: radionuclide imaging,Magnetic Resonance Imaging: methods,Tomography,Technetium: diagnostic use},
  language     = {eng},
  number       = {1},
  pages        = {41--44},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Neurosurgical Anesthesiology},
  title        = {Human cerebral blood volume (CBV) measured by dynamic susceptibility contrast MRI and 99mTc-RBC SPECT.},
  url          = {http://dx.doi.org/10.1097/ANA.0b013e31815d4c70},
  volume       = {20},
  year         = {2008},
}