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Increased ET(A) and ET(B) receptor contraction in the left internal mammary artery from patients with hypertension.

Nilsson, David LU ; Wackenfors, Angelica LU ; Gustafsson, Lotta LU ; Edvinsson, Lars LU ; Paulsson, Per LU ; Ingemansson, Richard LU and Malmsjö, Malin LU (2008) In Journal of Human Hypertension 22(3). p.226-229
Abstract
Patients with hypertension have an increased activity in the endothelin system and an increased vascular tone, which predisposes them to target organ damage. In the present study, in vitro pharmacology, real-time PCR and immunofluorescence techniques were used to show enhanced endothelin type A (ETA) and type B (ETB) receptor contraction and expression in the left internal mammary artery from patients with hypertension as compared to normotensive patients. These receptors may be important in the pathophysiology of hypertension.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Human Hypertension
volume
22
issue
3
pages
226 - 229
publisher
Nature Publishing Group
external identifiers
  • pmid:18075520
  • wos:000253138400015
  • scopus:39449106613
ISSN
1476-5527
DOI
10.1038/sj.jhh.1002317
language
English
LU publication?
yes
id
a5953524-c12d-4cf7-b6df-04a5dd9f4413 (old id 1035355)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18075520?dopt=Abstract
date added to LUP
2009-07-09 10:33:03
date last changed
2017-07-23 03:36:11
@article{a5953524-c12d-4cf7-b6df-04a5dd9f4413,
  abstract     = {Patients with hypertension have an increased activity in the endothelin system and an increased vascular tone, which predisposes them to target organ damage. In the present study, in vitro pharmacology, real-time PCR and immunofluorescence techniques were used to show enhanced endothelin type A (ETA) and type B (ETB) receptor contraction and expression in the left internal mammary artery from patients with hypertension as compared to normotensive patients. These receptors may be important in the pathophysiology of hypertension.},
  author       = {Nilsson, David and Wackenfors, Angelica and Gustafsson, Lotta and Edvinsson, Lars and Paulsson, Per and Ingemansson, Richard and Malmsjö, Malin},
  issn         = {1476-5527},
  language     = {eng},
  number       = {3},
  pages        = {226--229},
  publisher    = {Nature Publishing Group},
  series       = {Journal of Human Hypertension},
  title        = {Increased ET(A) and ET(B) receptor contraction in the left internal mammary artery from patients with hypertension.},
  url          = {http://dx.doi.org/10.1038/sj.jhh.1002317},
  volume       = {22},
  year         = {2008},
}