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Platelet surface-bound IgG and platelet-specific IgG in plasma in childhood thrombocytopenia

Donnér, M ; Békássy, Albert LU ; Heldrup, Jesper LU ; Wiebe, Thomas LU ; Garwicz, Stanislaw LU and Holmberg, Lars LU (1990) In Acta Paediatrica Scandinavica 79(3). p.328-334
Abstract
Quantification of platelet-bound immunoglobulin is widely used in the evaluation of thrombocytopenia. Several methods have been devised among which labelled ligand-binding assays seem to be most appropriate. In series of adult patients such assays have been shown to be superior in separating immune-thrombocytopenia from thrombocytopenia of non-immune causes. We studied 62 children with thrombocytopenia of various causes, using radiolabelled protein A as a ligand to measure platelet-surface bound IgG. The test was highly sensitive (93%) in detecting immune-thrombocytopenia. The specificity, however, was only 57%, which is less than in published studies of adults. In a number of cases presumed to be non-immune-thrombocytopenia, notably a few... (More)
Quantification of platelet-bound immunoglobulin is widely used in the evaluation of thrombocytopenia. Several methods have been devised among which labelled ligand-binding assays seem to be most appropriate. In series of adult patients such assays have been shown to be superior in separating immune-thrombocytopenia from thrombocytopenia of non-immune causes. We studied 62 children with thrombocytopenia of various causes, using radiolabelled protein A as a ligand to measure platelet-surface bound IgG. The test was highly sensitive (93%) in detecting immune-thrombocytopenia. The specificity, however, was only 57%, which is less than in published studies of adults. In a number of cases presumed to be non-immune-thrombocytopenia, notably a few patients with leukaemia and bone marrow aplasia, we found increased amounts of platelet surface-bound IgG. The significance of this finding is not clear. An indirect assay measuring platelet-specific IgG in plasma was less sensitive (46%) but highly specific for immune-thrombocytopenia (89%). The measurements of platelet-surface-bound IgG and platelet-specific IgG in plasma are of limited diagnostic value in childhood thrombocytopenia but are useful in following the treatment in chronic ITP. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
thrombocytopenia, immune thrombocytopenia, childhood, platelet
in
Acta Paediatrica Scandinavica
volume
79
issue
3
pages
328 - 334
publisher
Wiley-Blackwell
external identifiers
  • pmid:1692176
  • scopus:0025234014
ISSN
0001-656X
DOI
10.1111/j.1651-2227.1990.tb11465.x
language
English
LU publication?
yes
id
10375b24-6b33-4b1f-8f72-916a6805a55b (old id 1104970)
date added to LUP
2016-04-01 16:53:33
date last changed
2021-01-03 06:22:28
@article{10375b24-6b33-4b1f-8f72-916a6805a55b,
  abstract     = {{Quantification of platelet-bound immunoglobulin is widely used in the evaluation of thrombocytopenia. Several methods have been devised among which labelled ligand-binding assays seem to be most appropriate. In series of adult patients such assays have been shown to be superior in separating immune-thrombocytopenia from thrombocytopenia of non-immune causes. We studied 62 children with thrombocytopenia of various causes, using radiolabelled protein A as a ligand to measure platelet-surface bound IgG. The test was highly sensitive (93%) in detecting immune-thrombocytopenia. The specificity, however, was only 57%, which is less than in published studies of adults. In a number of cases presumed to be non-immune-thrombocytopenia, notably a few patients with leukaemia and bone marrow aplasia, we found increased amounts of platelet surface-bound IgG. The significance of this finding is not clear. An indirect assay measuring platelet-specific IgG in plasma was less sensitive (46%) but highly specific for immune-thrombocytopenia (89%). The measurements of platelet-surface-bound IgG and platelet-specific IgG in plasma are of limited diagnostic value in childhood thrombocytopenia but are useful in following the treatment in chronic ITP.}},
  author       = {{Donnér, M and Békássy, Albert and Heldrup, Jesper and Wiebe, Thomas and Garwicz, Stanislaw and Holmberg, Lars}},
  issn         = {{0001-656X}},
  keywords     = {{thrombocytopenia; immune thrombocytopenia; childhood; platelet}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{328--334}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Paediatrica Scandinavica}},
  title        = {{Platelet surface-bound IgG and platelet-specific IgG in plasma in childhood thrombocytopenia}},
  url          = {{http://dx.doi.org/10.1111/j.1651-2227.1990.tb11465.x}},
  doi          = {{10.1111/j.1651-2227.1990.tb11465.x}},
  volume       = {{79}},
  year         = {{1990}},
}