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Remodeling of the pulmonary circulation - a novel response to allergic airway inflammation

Rydell-Törmänen, Kristina LU (2008) In Lund University Faculty of Medicine Doctoral Dissertation Series 2008:35.
Abstract
Asthma is characterized, not only by inflammation but also by airway and vascular remodeling. Airway remodeling is established early in disease, structural alterations have been found in children, and is thought to contribute to asthma symptoms. Unfortunately, airway remodeling is considered difficult to reverse and it seldom resolves completely. Studies of vascular involvement in asthma have mainly focused on the tracheal and bronchial microcirculation, as these vessels are relatively easy to obtain. Some scattered studies have investigated bronchial and pulmonary arteries, using autopsy specimens. The overall aim of the project was to investigate vascular remodeling by utilizing two different animal models of allergic airway inflammation... (More)
Asthma is characterized, not only by inflammation but also by airway and vascular remodeling. Airway remodeling is established early in disease, structural alterations have been found in children, and is thought to contribute to asthma symptoms. Unfortunately, airway remodeling is considered difficult to reverse and it seldom resolves completely. Studies of vascular involvement in asthma have mainly focused on the tracheal and bronchial microcirculation, as these vessels are relatively easy to obtain. Some scattered studies have investigated bronchial and pulmonary arteries, using autopsy specimens. The overall aim of the project was to investigate vascular remodeling by utilizing two different animal models of allergic airway inflammation (where chicken egg albumin (OVA) or house dust mite (HDM) extract were used as allergens). More specifically the structural alterations of remodeling, the time frame of development and the resolution were investigated. The studies show that vascular remodeling is a feature of allergic airway inflammation, despite which allergen used to initialize the inflammatory response. Both the systemic tracheal microvessels as well as all parts of the pulmonary circulation undergo changes. The structural alterations of vascular remodeling induced by allergic airway inflammation, was similar to features as seen in airway remodeling. Vascular remodeling appears to be only partially reversible, as some structural alterations seem to remain even when the allergic inflammation is resolved.



In summary this thesis describes the involvement of the vasculature in airway inflammation, characterizes vascular remodeling and shows that similar structural alterations are induced by two different allergens. (Less)
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author
supervisor
opponent
  • Professor McDonald, Donald M, Dept. Anatomy, University of California, San Fransisco
organization
publishing date
type
Thesis
publication status
published
subject
keywords
Vascular remodeling, OVA, HDM, asthma
in
Lund University Faculty of Medicine Doctoral Dissertation Series
volume
2008:35
pages
180 pages
publisher
Inst för Experimentell Medicinsk Vetenskap, Lunds Universitet
defense location
Belfragesalen, BMC D15
defense date
2008-03-20 09:00
ISSN
1652-8220
ISBN
978-91-85897-88-9
language
English
LU publication?
yes
id
a1c97f00-a326-4663-bcc4-1861340a1d7b (old id 1038851)
date added to LUP
2008-02-28 16:25:49
date last changed
2016-09-19 08:44:47
@phdthesis{a1c97f00-a326-4663-bcc4-1861340a1d7b,
  abstract     = {Asthma is characterized, not only by inflammation but also by airway and vascular remodeling. Airway remodeling is established early in disease, structural alterations have been found in children, and is thought to contribute to asthma symptoms. Unfortunately, airway remodeling is considered difficult to reverse and it seldom resolves completely. Studies of vascular involvement in asthma have mainly focused on the tracheal and bronchial microcirculation, as these vessels are relatively easy to obtain. Some scattered studies have investigated bronchial and pulmonary arteries, using autopsy specimens. The overall aim of the project was to investigate vascular remodeling by utilizing two different animal models of allergic airway inflammation (where chicken egg albumin (OVA) or house dust mite (HDM) extract were used as allergens). More specifically the structural alterations of remodeling, the time frame of development and the resolution were investigated. The studies show that vascular remodeling is a feature of allergic airway inflammation, despite which allergen used to initialize the inflammatory response. Both the systemic tracheal microvessels as well as all parts of the pulmonary circulation undergo changes. The structural alterations of vascular remodeling induced by allergic airway inflammation, was similar to features as seen in airway remodeling. Vascular remodeling appears to be only partially reversible, as some structural alterations seem to remain even when the allergic inflammation is resolved. <br/><br>
<br/><br>
In summary this thesis describes the involvement of the vasculature in airway inflammation, characterizes vascular remodeling and shows that similar structural alterations are induced by two different allergens.},
  author       = {Rydell-Törmänen, Kristina},
  isbn         = {978-91-85897-88-9},
  issn         = {1652-8220},
  keyword      = {Vascular remodeling,OVA,HDM,asthma},
  language     = {eng},
  pages        = {180},
  publisher    = {Inst för Experimentell Medicinsk Vetenskap, Lunds Universitet},
  school       = {Lund University},
  series       = {Lund University Faculty of Medicine Doctoral Dissertation Series},
  title        = {Remodeling of the pulmonary circulation - a novel response to allergic airway inflammation},
  volume       = {2008:35},
  year         = {2008},
}