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Smoking and inflammatory bowel disease: comparison with lupus erythematiosus. A case-control study

Benoni, Cecilia LU ; Nilsson, Åke LU and Nived, Ola LU (1990) In Scandinavian Journal of Gastroenterology 25(7). p.751-755
Abstract
Smoking is rare in patients with ulcerative colitis (UC). Onsets are common after stopping smoking. Several observations suggest possible immunologic mechanisms in UC. As smoking has an immunosuppressive effect, a possible role of smoking in UC could be immunosuppression. In this study an analogous hypothesis was investigated by studying smoking habits in patients with systemic lupus erythematosus (SLE), an inflammatory multisystemic disease of unknown etiology, characterized by disturbances in cellular and humoral immunity. At onset, 23 of 56 patients were smokers and 2 probable smokers. Few were ex-smokers. The patients were matched for age, sex, and geographic vicinity, and multiple relative risks were calculated. No correlation could... (More)
Smoking is rare in patients with ulcerative colitis (UC). Onsets are common after stopping smoking. Several observations suggest possible immunologic mechanisms in UC. As smoking has an immunosuppressive effect, a possible role of smoking in UC could be immunosuppression. In this study an analogous hypothesis was investigated by studying smoking habits in patients with systemic lupus erythematosus (SLE), an inflammatory multisystemic disease of unknown etiology, characterized by disturbances in cellular and humoral immunity. At onset, 23 of 56 patients were smokers and 2 probable smokers. Few were ex-smokers. The patients were matched for age, sex, and geographic vicinity, and multiple relative risks were calculated. No correlation could be found between smoking/ex-smoking and SLE either at diagnosis or at interview, and no resemblance in habit to patients with UC was found. The present study provides no evidence that the immunosuppressive effect of smoking is sufficient to influence the clinical course of SLE and therefore by analogy does not support an immunosuppressive explanation of the possible protective effect of smoking in UC. (Less)
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author
; and
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Gastroenterology
volume
25
issue
7
pages
751 - 755
publisher
Taylor & Francis
external identifiers
  • pmid:2396091
  • scopus:0025347469
ISSN
1502-7708
DOI
10.3109/00365529008997603
language
Swedish
LU publication?
no
id
103c4c7e-2915-4eaa-8392-31a9b4d96a21
date added to LUP
2019-06-24 09:53:29
date last changed
2021-11-27 04:00:40
@article{103c4c7e-2915-4eaa-8392-31a9b4d96a21,
  abstract     = {{Smoking is rare in patients with ulcerative colitis (UC). Onsets are common after stopping smoking. Several observations suggest possible immunologic mechanisms in UC. As smoking has an immunosuppressive effect, a possible role of smoking in UC could be immunosuppression. In this study an analogous hypothesis was investigated by studying smoking habits in patients with systemic lupus erythematosus (SLE), an inflammatory multisystemic disease of unknown etiology, characterized by disturbances in cellular and humoral immunity. At onset, 23 of 56 patients were smokers and 2 probable smokers. Few were ex-smokers. The patients were matched for age, sex, and geographic vicinity, and multiple relative risks were calculated. No correlation could be found between smoking/ex-smoking and SLE either at diagnosis or at interview, and no resemblance in habit to patients with UC was found. The present study provides no evidence that the immunosuppressive effect of smoking is sufficient to influence the clinical course of SLE and therefore by analogy does not support an immunosuppressive explanation of the possible protective effect of smoking in UC.}},
  author       = {{Benoni, Cecilia and Nilsson, Åke and Nived, Ola}},
  issn         = {{1502-7708}},
  language     = {{swe}},
  month        = {{07}},
  number       = {{7}},
  pages        = {{751--755}},
  publisher    = {{Taylor & Francis}},
  series       = {{Scandinavian Journal of Gastroenterology}},
  title        = {{Smoking and inflammatory bowel disease: comparison with lupus erythematiosus. A case-control study}},
  url          = {{http://dx.doi.org/10.3109/00365529008997603}},
  doi          = {{10.3109/00365529008997603}},
  volume       = {{25}},
  year         = {{1990}},
}