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Prognostic value of cell adhesion in esophageal adenocarcinomas.

Falkenback, Dan LU ; Nilbert, Mef LU ; Öberg, Stefan LU and Johansson, J (2008) In Diseases of the Esophagus 21(2). p.97-102
Abstract
Increased understanding of the molecular processes associated with the dysplasia-adenocarcinoma sequence linked to Barrett's esophagus may be beneficial for early tumor detection and refined diagnosis as well as for improved prognostication. We applied immunohistochemical staining for the markers Ki-67, p53, beta-catenin and E-cadherin in order to evaluate their prognostic importance in 59 Barrett's esophagus-associated adenocarcinomas. Reduced or absent membranous E-cadherin staining was identified in 75% of the tumors and predicted poor prognosis in manova (hazard ratio [HR] 3.3, P = 0.05). The small subset of tumors with low levels (< 10%) of Ki-67 staining showed a worse prognosis (HR 3.2, P < 0.01), whereas immunostaining for... (More)
Increased understanding of the molecular processes associated with the dysplasia-adenocarcinoma sequence linked to Barrett's esophagus may be beneficial for early tumor detection and refined diagnosis as well as for improved prognostication. We applied immunohistochemical staining for the markers Ki-67, p53, beta-catenin and E-cadherin in order to evaluate their prognostic importance in 59 Barrett's esophagus-associated adenocarcinomas. Reduced or absent membranous E-cadherin staining was identified in 75% of the tumors and predicted poor prognosis in manova (hazard ratio [HR] 3.3, P = 0.05). The small subset of tumors with low levels (< 10%) of Ki-67 staining showed a worse prognosis (HR 3.2, P < 0.01), whereas immunostaining for p53 and beta-catenin showed no correlation with prognosis. Deranged cell adhesion has been demonstrated to be an early event in tumor development. The down-regulation of E-cadherin and its prognostic importance indicate that cell adhesion may be a prime area for targeted therapies in esophageal adenocarcinoma. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diseases of the Esophagus
volume
21
issue
2
pages
97 - 102
publisher
Wiley-Blackwell
external identifiers
  • pmid:18269642
  • wos:000252929600001
  • scopus:39049139719
ISSN
1120-8694
DOI
10.1111/j.1442-2050.2007.00749.x
language
English
LU publication?
yes
id
5215dbf6-a29b-4c68-99ea-df3c6d52f76c (old id 1042038)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18269642?dopt=Abstract
date added to LUP
2008-03-04 11:03:47
date last changed
2017-09-24 04:38:41
@article{5215dbf6-a29b-4c68-99ea-df3c6d52f76c,
  abstract     = {Increased understanding of the molecular processes associated with the dysplasia-adenocarcinoma sequence linked to Barrett's esophagus may be beneficial for early tumor detection and refined diagnosis as well as for improved prognostication. We applied immunohistochemical staining for the markers Ki-67, p53, beta-catenin and E-cadherin in order to evaluate their prognostic importance in 59 Barrett's esophagus-associated adenocarcinomas. Reduced or absent membranous E-cadherin staining was identified in 75% of the tumors and predicted poor prognosis in manova (hazard ratio [HR] 3.3, P = 0.05). The small subset of tumors with low levels (&lt; 10%) of Ki-67 staining showed a worse prognosis (HR 3.2, P &lt; 0.01), whereas immunostaining for p53 and beta-catenin showed no correlation with prognosis. Deranged cell adhesion has been demonstrated to be an early event in tumor development. The down-regulation of E-cadherin and its prognostic importance indicate that cell adhesion may be a prime area for targeted therapies in esophageal adenocarcinoma.},
  author       = {Falkenback, Dan and Nilbert, Mef and Öberg, Stefan and Johansson, J},
  issn         = {1120-8694},
  language     = {eng},
  number       = {2},
  pages        = {97--102},
  publisher    = {Wiley-Blackwell},
  series       = {Diseases of the Esophagus},
  title        = {Prognostic value of cell adhesion in esophageal adenocarcinomas.},
  url          = {http://dx.doi.org/10.1111/j.1442-2050.2007.00749.x},
  volume       = {21},
  year         = {2008},
}