Critical issues of clinical human embryonic stem cell therapy for brain repair.
(2008) In Trends in Neurosciences 31. p.146-153- Abstract
- Embryonic stem cells (ESCs) provide hope as a potential regenerative therapy for neurological conditions such as Parkinson's disease and spinal cord injury. Currently, ESC-based nervous system repair faces several problems. One major hurdle is related to problems in generating large and defined populations of the desired types of neurons from human ESCs (hESCs). Moreover, survival of grafted hESC-derived cells has varied and functional recovery in recipient animals has often been disappointing. Importantly, in clinical trials, adverse effects after surgery, including tumors or vigorous immune reactions, must be avoided. Here we highlight attempts to overcome these hurdles with hESCs intended for central nervous system repair. We focus on... (More)
- Embryonic stem cells (ESCs) provide hope as a potential regenerative therapy for neurological conditions such as Parkinson's disease and spinal cord injury. Currently, ESC-based nervous system repair faces several problems. One major hurdle is related to problems in generating large and defined populations of the desired types of neurons from human ESCs (hESCs). Moreover, survival of grafted hESC-derived cells has varied and functional recovery in recipient animals has often been disappointing. Importantly, in clinical trials, adverse effects after surgery, including tumors or vigorous immune reactions, must be avoided. Here we highlight attempts to overcome these hurdles with hESCs intended for central nervous system repair. We focus on hESC-derived dopamine-producing neurons that can be grafted in Parkinson's disease and identify critical experiments that need to be conducted before clinical trials can occur. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1042174
- author
- Li, Jia-Yi LU ; Christophersen, Nicolaj S ; Hall, Vanessa LU ; Soulet, Denis LU and Brundin, Patrik LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Trends in Neurosciences
- volume
- 31
- pages
- 146 - 153
- publisher
- Elsevier
- external identifiers
-
- pmid:18255164
- wos:000255104700005
- scopus:39949083205
- ISSN
- 1878-108X
- DOI
- 10.1016/j.tins.2007.12.001
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041), Neural Plasticity and Repair (013210080)
- id
- 78b6ee33-9ea8-4234-8dda-578d686f45f0 (old id 1042174)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18255164?dopt=Abstract
- date added to LUP
- 2016-04-04 09:10:39
- date last changed
- 2022-04-08 01:43:45
@article{78b6ee33-9ea8-4234-8dda-578d686f45f0, abstract = {{Embryonic stem cells (ESCs) provide hope as a potential regenerative therapy for neurological conditions such as Parkinson's disease and spinal cord injury. Currently, ESC-based nervous system repair faces several problems. One major hurdle is related to problems in generating large and defined populations of the desired types of neurons from human ESCs (hESCs). Moreover, survival of grafted hESC-derived cells has varied and functional recovery in recipient animals has often been disappointing. Importantly, in clinical trials, adverse effects after surgery, including tumors or vigorous immune reactions, must be avoided. Here we highlight attempts to overcome these hurdles with hESCs intended for central nervous system repair. We focus on hESC-derived dopamine-producing neurons that can be grafted in Parkinson's disease and identify critical experiments that need to be conducted before clinical trials can occur.}}, author = {{Li, Jia-Yi and Christophersen, Nicolaj S and Hall, Vanessa and Soulet, Denis and Brundin, Patrik}}, issn = {{1878-108X}}, language = {{eng}}, pages = {{146--153}}, publisher = {{Elsevier}}, series = {{Trends in Neurosciences}}, title = {{Critical issues of clinical human embryonic stem cell therapy for brain repair.}}, url = {{http://dx.doi.org/10.1016/j.tins.2007.12.001}}, doi = {{10.1016/j.tins.2007.12.001}}, volume = {{31}}, year = {{2008}}, }