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A link between sICAM-1, ACE and parietal blood flow in the aging brain.

Janciauskiene, Sabina LU ; Erikson, Catarina LU and Warkentin, Siegbert LU (2009) In Neurobiology of Aging 30. p.1504-1511
Abstract
A connection between Alzheimer's disease (AD) and endothelium pathology has been inferred from measured decreases in both blood flow and metabolism in the parietal and temporal cortex. However, it is not known whether these alterations are seen in normal aging. We performed regional cerebral blood flow (rCBF) measurements in 22 AD patients and in 44 non-demented subjects during a simple test of information processing speed. Cerebrospinal fluid (CSF) levels of angiotensin-converting enzyme (ACE) and the soluble form of intercellular adhesion molecule-1 (sICAM-1) were analyzed in non-demented subjects. We found correlations between sICAM-1 and ACE (p=0.004), and sICAM (but not ACE) and CSF/plasma albumin ratio (p<0.0001). Higher... (More)
A connection between Alzheimer's disease (AD) and endothelium pathology has been inferred from measured decreases in both blood flow and metabolism in the parietal and temporal cortex. However, it is not known whether these alterations are seen in normal aging. We performed regional cerebral blood flow (rCBF) measurements in 22 AD patients and in 44 non-demented subjects during a simple test of information processing speed. Cerebrospinal fluid (CSF) levels of angiotensin-converting enzyme (ACE) and the soluble form of intercellular adhesion molecule-1 (sICAM-1) were analyzed in non-demented subjects. We found correlations between sICAM-1 and ACE (p=0.004), and sICAM (but not ACE) and CSF/plasma albumin ratio (p<0.0001). Higher concentrations of sICAM-1 (>893ng/L) and ACE (>5.22mug/L) were exclusively associated with lower parietal blood flow (p<0.001). The rCBF patterns in the AD and non-demented subjects with biomarker levels above median showed similar reductions in the temporoparietal areas. Our findings provide evidence that elevated CSF sICAM-1 and ACE are associated with lower perfusion levels in the parietal cortex of cognitively intact elderly. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neurobiology of Aging
volume
30
pages
1504 - 1511
publisher
Elsevier
external identifiers
  • pmid:18243419
  • wos:000268783200017
  • scopus:67650470255
ISSN
1558-1497
DOI
10.1016/j.neurobiolaging.2007.08.025
language
English
LU publication?
yes
id
65d9faa8-b5b6-4146-9d75-4cce65428bce (old id 1042310)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18243419?dopt=Abstract
date added to LUP
2008-03-05 11:06:06
date last changed
2017-08-20 03:44:04
@article{65d9faa8-b5b6-4146-9d75-4cce65428bce,
  abstract     = {A connection between Alzheimer's disease (AD) and endothelium pathology has been inferred from measured decreases in both blood flow and metabolism in the parietal and temporal cortex. However, it is not known whether these alterations are seen in normal aging. We performed regional cerebral blood flow (rCBF) measurements in 22 AD patients and in 44 non-demented subjects during a simple test of information processing speed. Cerebrospinal fluid (CSF) levels of angiotensin-converting enzyme (ACE) and the soluble form of intercellular adhesion molecule-1 (sICAM-1) were analyzed in non-demented subjects. We found correlations between sICAM-1 and ACE (p=0.004), and sICAM (but not ACE) and CSF/plasma albumin ratio (p&lt;0.0001). Higher concentrations of sICAM-1 (&gt;893ng/L) and ACE (&gt;5.22mug/L) were exclusively associated with lower parietal blood flow (p&lt;0.001). The rCBF patterns in the AD and non-demented subjects with biomarker levels above median showed similar reductions in the temporoparietal areas. Our findings provide evidence that elevated CSF sICAM-1 and ACE are associated with lower perfusion levels in the parietal cortex of cognitively intact elderly.},
  author       = {Janciauskiene, Sabina and Erikson, Catarina and Warkentin, Siegbert},
  issn         = {1558-1497},
  language     = {eng},
  pages        = {1504--1511},
  publisher    = {Elsevier},
  series       = {Neurobiology of Aging},
  title        = {A link between sICAM-1, ACE and parietal blood flow in the aging brain.},
  url          = {http://dx.doi.org/10.1016/j.neurobiolaging.2007.08.025},
  volume       = {30},
  year         = {2009},
}