Cyclodextrin-Based Nanosponges : Overview and Opportunities
Utzeri, Gianluca LU
; Matias, Pedro M.C.
; Murtinho, Dina
and Valente, Artur J.M.
(2022)
In Frontiers in Chemistry
10.
- Abstract
Nanosponges are solid cross-linked polymeric nano-sized porous structures. This broad concept involves, among others, metal organic frameworks and hydrogels. The focus of this manuscript is on cyclodextrin-based nanosponges. Cyclodextrins are cyclic oligomers of glucose derived from starch. The combined external hydrophilicity with the internal hydrophobic surface constitute a unique “microenvironment”, that confers cyclodextrins the peculiar ability to form inclusion host‒guest complexes with many hydrophobic substances. These complexes may impart beneficial modifications of the properties of guest molecules such as solubility enhancement and stabilization of labile guests. These properties complemented with the possibility of using... (More)
Nanosponges are solid cross-linked polymeric nano-sized porous structures. This broad concept involves, among others, metal organic frameworks and hydrogels. The focus of this manuscript is on cyclodextrin-based nanosponges. Cyclodextrins are cyclic oligomers of glucose derived from starch. The combined external hydrophilicity with the internal hydrophobic surface constitute a unique “microenvironment”, that confers cyclodextrins the peculiar ability to form inclusion host‒guest complexes with many hydrophobic substances. These complexes may impart beneficial modifications of the properties of guest molecules such as solubility enhancement and stabilization of labile guests. These properties complemented with the possibility of using different crosslinkers and high polymeric surface, make these sponges highly suitable for a large range of applications. Despite that, in the last 2 decades, cyclodextrin-based nanosponges have been developed for pharmaceutical and biomedical applications, taking advantage of the nontoxicity of cyclodextrins towards humans. This paper provides a critical and timely compilation of the contributions involving cyclodextrins nanosponges for those areas, but also paves the way for other important applications, including water and soil remediation and catalysis.
(Less)
- author
- Utzeri, Gianluca
LU
; Matias, Pedro M.C.
; Murtinho, Dina
and Valente, Artur J.M.
- publishing date
- 2022-03-24
- type
- Contribution to journal
- publication status
- published
- keywords
- crosslinked polymers, cyclodextrins, multipurpose structures, nanosponges, responsive materials, supramolecular interactions
- in
- Frontiers in Chemistry
- volume
- 10
- article number
- 859406
- publisher
- Frontiers Media S. A.
- external identifiers
-
- scopus:85128298011
- ISSN
- 2296-2646
- DOI
- 10.3389/fchem.2022.859406
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: Copyright © 2022 Utzeri, Matias, Murtinho and Valente.
- id
- 104b83ab-2dd3-4e8a-bae3-211a8071022f
- date added to LUP
- 2024-07-22 10:51:10
- date last changed
- 2024-08-15 10:03:30
@article{104b83ab-2dd3-4e8a-bae3-211a8071022f,
abstract = {{<p>Nanosponges are solid cross-linked polymeric nano-sized porous structures. This broad concept involves, among others, metal organic frameworks and hydrogels. The focus of this manuscript is on cyclodextrin-based nanosponges. Cyclodextrins are cyclic oligomers of glucose derived from starch. The combined external hydrophilicity with the internal hydrophobic surface constitute a unique “microenvironment”, that confers cyclodextrins the peculiar ability to form inclusion host‒guest complexes with many hydrophobic substances. These complexes may impart beneficial modifications of the properties of guest molecules such as solubility enhancement and stabilization of labile guests. These properties complemented with the possibility of using different crosslinkers and high polymeric surface, make these sponges highly suitable for a large range of applications. Despite that, in the last 2 decades, cyclodextrin-based nanosponges have been developed for pharmaceutical and biomedical applications, taking advantage of the nontoxicity of cyclodextrins towards humans. This paper provides a critical and timely compilation of the contributions involving cyclodextrins nanosponges for those areas, but also paves the way for other important applications, including water and soil remediation and catalysis.</p>}},
author = {{Utzeri, Gianluca and Matias, Pedro M.C. and Murtinho, Dina and Valente, Artur J.M.}},
issn = {{2296-2646}},
keywords = {{crosslinked polymers; cyclodextrins; multipurpose structures; nanosponges; responsive materials; supramolecular interactions}},
language = {{eng}},
month = {{03}},
publisher = {{Frontiers Media S. A.}},
series = {{Frontiers in Chemistry}},
title = {{Cyclodextrin-Based Nanosponges : Overview and Opportunities}},
url = {{http://dx.doi.org/10.3389/fchem.2022.859406}},
doi = {{10.3389/fchem.2022.859406}},
volume = {{10}},
year = {{2022}},
}