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Chemical investigations of disperse dyes in patch test preparations.

Ryberg, Kristina LU ; Gruvberger, Birgitta LU ; Zimerson, Erik LU ; Isaksson, Marléne LU ; Persson, Lena; Sörensen, Östen LU ; Goossens, An and Bruze, Magnus LU (2008) In Contact Dermatitis 58(4). p.199-209
Abstract
BACKGROUND: Contact allergy to textile dyes is not uncommon. The allergy is detected by patch testing patients with commercial patch test preparations. OBJECTIVE: To investigate 8 disperse dyes (DDs) used for patch testing in the departments in Malmö and in Leuven and to compare them with test preparations used at various dermatology departments. Materials/Methods: The investigated DDs were Disperse Blue (DB) 35, 106, and 124, Disperse Yellow (DY) 3, Disperse Orange (DO) 1 and 3, and Disperse Red (DR) 1 and 17. From 13 clinics, 107 petrolatum preparations were analysed using high-performance liquid chromatography and thin-layer chromatography (TLC), and compared with reference substances obtained at the Malmö laboratory. Concerning DB 35,... (More)
BACKGROUND: Contact allergy to textile dyes is not uncommon. The allergy is detected by patch testing patients with commercial patch test preparations. OBJECTIVE: To investigate 8 disperse dyes (DDs) used for patch testing in the departments in Malmö and in Leuven and to compare them with test preparations used at various dermatology departments. Materials/Methods: The investigated DDs were Disperse Blue (DB) 35, 106, and 124, Disperse Yellow (DY) 3, Disperse Orange (DO) 1 and 3, and Disperse Red (DR) 1 and 17. From 13 clinics, 107 petrolatum preparations were analysed using high-performance liquid chromatography and thin-layer chromatography (TLC), and compared with reference substances obtained at the Malmö laboratory. Concerning DB 35, no reference substance could be identified. RESULTS: TLC visualized impurities in all DDs. For each DD, except DB 35, the mean concentration in the preparations labelled to contain 1.0% (w/w) were DB 106: 0.30%, DB 124: 0.25%, DY 3: 0.44%, DO 1: 0.40%, DO 3: 0.68%, DR 1: 0.49%, and DR 17: 0.35%; there were variations between the samples also with regard to the number of impurities. DO 3 could not be demonstrated in 4/15 preparations labelled DO 3. CONCLUSION: The results may have implications for individual diagnosis and prevention and when comparing test results from various centres. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Contact Dermatitis
volume
58
issue
4
pages
199 - 209
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • pmid:18353027
  • wos:000254122500003
  • scopus:41049106385
ISSN
0105-1873
DOI
10.1111/j.1600-0536.2007.01298.x
language
English
LU publication?
yes
id
17dcf117-d6e3-4dbf-851c-3eb19e9e58d0 (old id 1052300)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18353027?dopt=Abstract
date added to LUP
2008-04-02 16:52:46
date last changed
2017-08-20 04:38:27
@article{17dcf117-d6e3-4dbf-851c-3eb19e9e58d0,
  abstract     = {BACKGROUND: Contact allergy to textile dyes is not uncommon. The allergy is detected by patch testing patients with commercial patch test preparations. OBJECTIVE: To investigate 8 disperse dyes (DDs) used for patch testing in the departments in Malmö and in Leuven and to compare them with test preparations used at various dermatology departments. Materials/Methods: The investigated DDs were Disperse Blue (DB) 35, 106, and 124, Disperse Yellow (DY) 3, Disperse Orange (DO) 1 and 3, and Disperse Red (DR) 1 and 17. From 13 clinics, 107 petrolatum preparations were analysed using high-performance liquid chromatography and thin-layer chromatography (TLC), and compared with reference substances obtained at the Malmö laboratory. Concerning DB 35, no reference substance could be identified. RESULTS: TLC visualized impurities in all DDs. For each DD, except DB 35, the mean concentration in the preparations labelled to contain 1.0% (w/w) were DB 106: 0.30%, DB 124: 0.25%, DY 3: 0.44%, DO 1: 0.40%, DO 3: 0.68%, DR 1: 0.49%, and DR 17: 0.35%; there were variations between the samples also with regard to the number of impurities. DO 3 could not be demonstrated in 4/15 preparations labelled DO 3. CONCLUSION: The results may have implications for individual diagnosis and prevention and when comparing test results from various centres.},
  author       = {Ryberg, Kristina and Gruvberger, Birgitta and Zimerson, Erik and Isaksson, Marléne and Persson, Lena and Sörensen, Östen and Goossens, An and Bruze, Magnus},
  issn         = {0105-1873},
  language     = {eng},
  number       = {4},
  pages        = {199--209},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Chemical investigations of disperse dyes in patch test preparations.},
  url          = {http://dx.doi.org/10.1111/j.1600-0536.2007.01298.x},
  volume       = {58},
  year         = {2008},
}