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Increased Prevalence of Multiple Sclerosis Among COPD Patients and Their First-Degree Relatives: A Population-based Study.

Egesten, Arne LU ; Brandt, Lena ; Olsson, Tomas ; Granath, Fredrik ; Inghammar, Malin LU ; Löfdahl, Claes-Göran LU and Ekbom, Anders (2008) In Lung 186. p.173-178
Abstract
In both chronic obstructive pulmonary disease (COPD) and multiple sclerosis (MS), combinations of environmental and genetic factors are likely to increase the vulnerability to acquire disease. This study was undertaken to investigate any possible comorbidity of COPD and MS, thus indicating common inflammatory vulnerability. Individuals with a diagnosis of COPD (including chronic bronchitis and emphysema) during 1987-2002, according to the Swedish Inpatient and Cause of Death Registers, were identified (180,239 individuals). Thereafter, controls and first-degree relatives of both cases and controls were identified. Finally, all individuals were compared with the Inpatient Register to identify individuals discharged with a diagnosis of MS.... (More)
In both chronic obstructive pulmonary disease (COPD) and multiple sclerosis (MS), combinations of environmental and genetic factors are likely to increase the vulnerability to acquire disease. This study was undertaken to investigate any possible comorbidity of COPD and MS, thus indicating common inflammatory vulnerability. Individuals with a diagnosis of COPD (including chronic bronchitis and emphysema) during 1987-2002, according to the Swedish Inpatient and Cause of Death Registers, were identified (180,239 individuals). Thereafter, controls and first-degree relatives of both cases and controls were identified. Finally, all individuals were compared with the Inpatient Register to identify individuals discharged with a diagnosis of MS. In the COPD cohort, there was a more than twofold increased risk of MS compared with controls (HR 2.51; 95% CI 2.13-2.98). The risk of MS was even more pronounced among individuals discharged with a diagnosis of COPD before 60 years of age (HR 6.37; 95% CI 3.58-9.68). There was also an increased risk of MS among mothers (HR 2.24; 95% CI 1.04-4.61) and siblings (HR 1.50; 95% CI 1.08-2.08) of COPD patients. This study indicates that COPD and MS have an inflammatory vulnerability in common, at least in a subgroup of patients. These diseases may share inflammatory pathways, including predisposing variants of genes. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Lung
volume
186
pages
173 - 178
publisher
Springer
external identifiers
  • pmid:18351419
  • wos:000256324400006
  • scopus:44549087346
ISSN
1432-1750
DOI
10.1007/s00408-008-9081-y
language
English
LU publication?
yes
id
2dc5d431-acd8-43eb-8a36-cfb9448f333c (old id 1052346)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18351419?dopt=Abstract
date added to LUP
2016-04-04 09:12:22
date last changed
2022-01-29 08:44:37
@article{2dc5d431-acd8-43eb-8a36-cfb9448f333c,
  abstract     = {{In both chronic obstructive pulmonary disease (COPD) and multiple sclerosis (MS), combinations of environmental and genetic factors are likely to increase the vulnerability to acquire disease. This study was undertaken to investigate any possible comorbidity of COPD and MS, thus indicating common inflammatory vulnerability. Individuals with a diagnosis of COPD (including chronic bronchitis and emphysema) during 1987-2002, according to the Swedish Inpatient and Cause of Death Registers, were identified (180,239 individuals). Thereafter, controls and first-degree relatives of both cases and controls were identified. Finally, all individuals were compared with the Inpatient Register to identify individuals discharged with a diagnosis of MS. In the COPD cohort, there was a more than twofold increased risk of MS compared with controls (HR 2.51; 95% CI 2.13-2.98). The risk of MS was even more pronounced among individuals discharged with a diagnosis of COPD before 60 years of age (HR 6.37; 95% CI 3.58-9.68). There was also an increased risk of MS among mothers (HR 2.24; 95% CI 1.04-4.61) and siblings (HR 1.50; 95% CI 1.08-2.08) of COPD patients. This study indicates that COPD and MS have an inflammatory vulnerability in common, at least in a subgroup of patients. These diseases may share inflammatory pathways, including predisposing variants of genes.}},
  author       = {{Egesten, Arne and Brandt, Lena and Olsson, Tomas and Granath, Fredrik and Inghammar, Malin and Löfdahl, Claes-Göran and Ekbom, Anders}},
  issn         = {{1432-1750}},
  language     = {{eng}},
  pages        = {{173--178}},
  publisher    = {{Springer}},
  series       = {{Lung}},
  title        = {{Increased Prevalence of Multiple Sclerosis Among COPD Patients and Their First-Degree Relatives: A Population-based Study.}},
  url          = {{http://dx.doi.org/10.1007/s00408-008-9081-y}},
  doi          = {{10.1007/s00408-008-9081-y}},
  volume       = {{186}},
  year         = {{2008}},
}