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Usage of Air Monitoring and Biomarkers of Isocyanate Exposure to Assess the Effect of a Control Intervention.

Tinnerberg, Håkan LU and Mattsson, Christian LU (2008) In Annals of Occupational Hygiene 52. p.187-194
Abstract
Exposure to isocyanates is known to have respiratory effects in workers and therefore it is essential to monitor the occupational exposure. An earlier study of a continuous foaming plant using toluene diisocyanate (TDI) showed that the exposure to isocyanates can be high. Since then several preventive actions were implemented at the plant. The aim of this study was to observe the effect of these actions measured by air and biological monitoring. Four workers were monitored in the year 2000 and six in 2005, with air measurements during the continuous foaming process, and with measurements of biomarkers in one plasma sample each year and with two urinary samples being collected in the year 2000 and one in 2005. The median TDI air... (More)
Exposure to isocyanates is known to have respiratory effects in workers and therefore it is essential to monitor the occupational exposure. An earlier study of a continuous foaming plant using toluene diisocyanate (TDI) showed that the exposure to isocyanates can be high. Since then several preventive actions were implemented at the plant. The aim of this study was to observe the effect of these actions measured by air and biological monitoring. Four workers were monitored in the year 2000 and six in 2005, with air measurements during the continuous foaming process, and with measurements of biomarkers in one plasma sample each year and with two urinary samples being collected in the year 2000 and one in 2005. The median TDI air concentrations in 2005 were approximately 20% of the 2000 levels and the median levels of biomarkers in 2005 were approximately 10% of the 2000 levels. According to our measurements the preventive action had a real effect to decrease the exposure to TDI. As the workers both before and after the preventive actions used personal protective equipment, the use of biomarkers was necessary to assess the real gain in the preventive actions. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of Occupational Hygiene
volume
52
pages
187 - 194
publisher
Oxford University Press
external identifiers
  • PMID:18344533
  • WOS:000254877300005
  • Scopus:44949181094
ISSN
1475-3162
DOI
10.1093/annhyg/men006
language
English
LU publication?
yes
id
ccc266c3-afc4-4e73-894e-e3264827a2e4 (old id 1052409)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18344533?dopt=Abstract
date added to LUP
2008-04-03 08:10:34
date last changed
2017-01-01 07:50:51
@article{ccc266c3-afc4-4e73-894e-e3264827a2e4,
  abstract     = {Exposure to isocyanates is known to have respiratory effects in workers and therefore it is essential to monitor the occupational exposure. An earlier study of a continuous foaming plant using toluene diisocyanate (TDI) showed that the exposure to isocyanates can be high. Since then several preventive actions were implemented at the plant. The aim of this study was to observe the effect of these actions measured by air and biological monitoring. Four workers were monitored in the year 2000 and six in 2005, with air measurements during the continuous foaming process, and with measurements of biomarkers in one plasma sample each year and with two urinary samples being collected in the year 2000 and one in 2005. The median TDI air concentrations in 2005 were approximately 20% of the 2000 levels and the median levels of biomarkers in 2005 were approximately 10% of the 2000 levels. According to our measurements the preventive action had a real effect to decrease the exposure to TDI. As the workers both before and after the preventive actions used personal protective equipment, the use of biomarkers was necessary to assess the real gain in the preventive actions.},
  author       = {Tinnerberg, Håkan and Mattsson, Christian},
  issn         = {1475-3162},
  language     = {eng},
  pages        = {187--194},
  publisher    = {Oxford University Press},
  series       = {Annals of Occupational Hygiene},
  title        = {Usage of Air Monitoring and Biomarkers of Isocyanate Exposure to Assess the Effect of a Control Intervention.},
  url          = {http://dx.doi.org/10.1093/annhyg/men006},
  volume       = {52},
  year         = {2008},
}