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Kallikrein-related peptidases.

Lundwall, Åke LU and Brattsand, M (2008) In Cellular and Molecular Life Sciences 65. p.2019-2038
Abstract
Kallikrein 1 (KLK1), a key component of the kallikrein-kinin system, originates from a locus on the long arm of chromosome 19 that contains several related serine endopeptidases. The biological role of these kallikrein-related peptidases is not clear, but emerging evidence suggests that they might be important in several physiological systems, e.g., in male reproduction, skin homeostasis, tooth enamel formation and neural development and plasticity. The kallikrein locus has undergone some major evolutionary events. Most spectacular are relatively recent duplications of KLK1 that have created 13 and 9 functional genes that are unique to the mouse and the rat, respectively. Human paralogs are KLK2 and KLK3: the latter encoding the cancer... (More)
Kallikrein 1 (KLK1), a key component of the kallikrein-kinin system, originates from a locus on the long arm of chromosome 19 that contains several related serine endopeptidases. The biological role of these kallikrein-related peptidases is not clear, but emerging evidence suggests that they might be important in several physiological systems, e.g., in male reproduction, skin homeostasis, tooth enamel formation and neural development and plasticity. The kallikrein locus has undergone some major evolutionary events. Most spectacular are relatively recent duplications of KLK1 that have created 13 and 9 functional genes that are unique to the mouse and the rat, respectively. Human paralogs are KLK2 and KLK3: the latter encoding the cancer biomarker prostate-specific antigen. In this review on kallikrein-related peptidases, the focus is on their evolution, their role in skin homeostasis and semen liquefaction, and their utility as cancer biomarkers. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cellular and Molecular Life Sciences
volume
65
pages
2019 - 2038
publisher
Birkhaüser
external identifiers
  • PMID:18344018
  • WOS:000257368600004
  • Scopus:46449093665
ISSN
1420-9071
DOI
10.1007/s00018-008-8024-3
language
English
LU publication?
yes
id
fbba6ddd-8130-40c0-885e-791f634c439a (old id 1052443)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18344018?dopt=Abstract
date added to LUP
2008-04-02 12:02:32
date last changed
2017-02-05 04:35:49
@article{fbba6ddd-8130-40c0-885e-791f634c439a,
  abstract     = {Kallikrein 1 (KLK1), a key component of the kallikrein-kinin system, originates from a locus on the long arm of chromosome 19 that contains several related serine endopeptidases. The biological role of these kallikrein-related peptidases is not clear, but emerging evidence suggests that they might be important in several physiological systems, e.g., in male reproduction, skin homeostasis, tooth enamel formation and neural development and plasticity. The kallikrein locus has undergone some major evolutionary events. Most spectacular are relatively recent duplications of KLK1 that have created 13 and 9 functional genes that are unique to the mouse and the rat, respectively. Human paralogs are KLK2 and KLK3: the latter encoding the cancer biomarker prostate-specific antigen. In this review on kallikrein-related peptidases, the focus is on their evolution, their role in skin homeostasis and semen liquefaction, and their utility as cancer biomarkers.},
  author       = {Lundwall, Åke and Brattsand, M},
  issn         = {1420-9071},
  language     = {eng},
  pages        = {2019--2038},
  publisher    = {Birkhaüser},
  series       = {Cellular and Molecular Life Sciences},
  title        = {Kallikrein-related peptidases.},
  url          = {http://dx.doi.org/10.1007/s00018-008-8024-3},
  volume       = {65},
  year         = {2008},
}