A Subset of CD5- Diffuse Large B-Cell Lymphomas Expresses Nuclear Cyclin D1 With Aberrations at the CCND1 Locus.
(2008) In American Journal of Clinical Pathology 129(4). p.630-638- Abstract
- In 231 diffuse large B-cell lymphomas, the expression of cyclin D1 and CD5 was evaluated. All cases were CD5-. Ten (4.3%) were positive for cyclin D1 and were subjected to fluorescence in situ hybridization at the CCND1 locus. One case showed the t(11;14). In another case, the telomeric probe signal for cyclin D1 was lost in most tumor cells, and in a small proportion of the cells, there were fluorescence signals indicative of the t(11;14). Two other cases displayed additional cyclin D1 signals in the absence of the t(11;14). All cases but 1 were positive for bcl-6 or MUM1, disfavoring the possibility of misdiagnosed blastoid variants of CD5- mantle cell lymphomas. Thus, contrary to the current view, there seems to exist a certain number... (More)
- In 231 diffuse large B-cell lymphomas, the expression of cyclin D1 and CD5 was evaluated. All cases were CD5-. Ten (4.3%) were positive for cyclin D1 and were subjected to fluorescence in situ hybridization at the CCND1 locus. One case showed the t(11;14). In another case, the telomeric probe signal for cyclin D1 was lost in most tumor cells, and in a small proportion of the cells, there were fluorescence signals indicative of the t(11;14). Two other cases displayed additional cyclin D1 signals in the absence of the t(11;14). All cases but 1 were positive for bcl-6 or MUM1, disfavoring the possibility of misdiagnosed blastoid variants of CD5- mantle cell lymphomas. Thus, contrary to the current view, there seems to exist a certain number of cyclin D1+ and CD5- diffuse large B-cell lymphomas, some of which have structural aberrations at the CCND1 locus, including the t(11;14). (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1052448
- author
- Ehinger, Mats LU ; Linderoth, Johan LU ; Christensson, Birger ; Sander, Birgitta and Cavallin-Ståhl, Eva LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- American Journal of Clinical Pathology
- volume
- 129
- issue
- 4
- pages
- 630 - 638
- publisher
- Oxford University Press
- external identifiers
-
- pmid:18343791
- wos:000254127600015
- scopus:42949153437
- ISSN
- 1943-7722
- DOI
- 10.1309/42CQ0HU7XEY9QMQX
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Oncology, MV (013035000)
- id
- ad348052-69b1-4955-8cd1-10dba4a0acd3 (old id 1052448)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18343791?dopt=Abstract
- date added to LUP
- 2016-04-04 09:40:20
- date last changed
- 2022-04-16 00:30:24
@article{ad348052-69b1-4955-8cd1-10dba4a0acd3, abstract = {{In 231 diffuse large B-cell lymphomas, the expression of cyclin D1 and CD5 was evaluated. All cases were CD5-. Ten (4.3%) were positive for cyclin D1 and were subjected to fluorescence in situ hybridization at the CCND1 locus. One case showed the t(11;14). In another case, the telomeric probe signal for cyclin D1 was lost in most tumor cells, and in a small proportion of the cells, there were fluorescence signals indicative of the t(11;14). Two other cases displayed additional cyclin D1 signals in the absence of the t(11;14). All cases but 1 were positive for bcl-6 or MUM1, disfavoring the possibility of misdiagnosed blastoid variants of CD5- mantle cell lymphomas. Thus, contrary to the current view, there seems to exist a certain number of cyclin D1+ and CD5- diffuse large B-cell lymphomas, some of which have structural aberrations at the CCND1 locus, including the t(11;14).}}, author = {{Ehinger, Mats and Linderoth, Johan and Christensson, Birger and Sander, Birgitta and Cavallin-Ståhl, Eva}}, issn = {{1943-7722}}, language = {{eng}}, number = {{4}}, pages = {{630--638}}, publisher = {{Oxford University Press}}, series = {{American Journal of Clinical Pathology}}, title = {{A Subset of CD5- Diffuse Large B-Cell Lymphomas Expresses Nuclear Cyclin D1 With Aberrations at the CCND1 Locus.}}, url = {{http://dx.doi.org/10.1309/42CQ0HU7XEY9QMQX}}, doi = {{10.1309/42CQ0HU7XEY9QMQX}}, volume = {{129}}, year = {{2008}}, }