Therapeutic cleavage of IgG: new avenues for treating inflammation.
(2008) In Trends in Immunology 29. p.173-178- Abstract
- Autoantibodies developing in humans contribute to the pathogenesis of several diseases, and injected therapeutic antibodies can also trigger adverse side effects. An efficient and rapid elimination of these antibodies are therefore critically needed. Antibody removal by plasmapheresis and immunoadsorption are commonly used methods but have their own limitations. Bacterial enzymes that can cleave IgG molecules or remove carbohydrate moieties to ameliorate their immunogenicity or effector functions in vivo offer new avenues for drug development. Recent discoveries highlight the possibility of cleaving or modifying IgG in vivo by injection of enzymes. Such an approach opens up new therapeutic possibilities not only for the control of... (More)
- Autoantibodies developing in humans contribute to the pathogenesis of several diseases, and injected therapeutic antibodies can also trigger adverse side effects. An efficient and rapid elimination of these antibodies are therefore critically needed. Antibody removal by plasmapheresis and immunoadsorption are commonly used methods but have their own limitations. Bacterial enzymes that can cleave IgG molecules or remove carbohydrate moieties to ameliorate their immunogenicity or effector functions in vivo offer new avenues for drug development. Recent discoveries highlight the possibility of cleaving or modifying IgG in vivo by injection of enzymes. Such an approach opens up new therapeutic possibilities not only for the control of pathogenic antibody-mediated inflammatory diseases but also allograft rejection or the treatment of side-effects of 'biologicals' such as monoclonal antibodies. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1052713
- author
- Nandakumar, Kutty Selva and Holmdahl, Rikard LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Trends in Immunology
- volume
- 29
- pages
- 173 - 178
- publisher
- Elsevier
- external identifiers
-
- pmid:18328782
- wos:000255469300022
- scopus:41349090782
- pmid:18328782
- ISSN
- 1471-4981
- DOI
- 10.1016/j.it.2008.01.007
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Inflammation Research (013212019)
- id
- 76dbf97b-7ff2-4db4-8638-cae02fdb98db (old id 1052713)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18328782?dopt=Abstract
- date added to LUP
- 2016-04-04 08:05:37
- date last changed
- 2022-01-29 02:59:54
@article{76dbf97b-7ff2-4db4-8638-cae02fdb98db,
abstract = {{Autoantibodies developing in humans contribute to the pathogenesis of several diseases, and injected therapeutic antibodies can also trigger adverse side effects. An efficient and rapid elimination of these antibodies are therefore critically needed. Antibody removal by plasmapheresis and immunoadsorption are commonly used methods but have their own limitations. Bacterial enzymes that can cleave IgG molecules or remove carbohydrate moieties to ameliorate their immunogenicity or effector functions in vivo offer new avenues for drug development. Recent discoveries highlight the possibility of cleaving or modifying IgG in vivo by injection of enzymes. Such an approach opens up new therapeutic possibilities not only for the control of pathogenic antibody-mediated inflammatory diseases but also allograft rejection or the treatment of side-effects of 'biologicals' such as monoclonal antibodies.}},
author = {{Nandakumar, Kutty Selva and Holmdahl, Rikard}},
issn = {{1471-4981}},
language = {{eng}},
pages = {{173--178}},
publisher = {{Elsevier}},
series = {{Trends in Immunology}},
title = {{Therapeutic cleavage of IgG: new avenues for treating inflammation.}},
url = {{https://lup.lub.lu.se/search/files/5166019/1059621.pdf}},
doi = {{10.1016/j.it.2008.01.007}},
volume = {{29}},
year = {{2008}},
}