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Xylose as a carrier for boron containing compounds.

Jacobsson, Mårten LU ; Winander, Cecilia; Mani, Katrin LU and Ellervik, Ulf LU (2008) In Bioorganic & Medicinal Chemistry Letters 18(7). p.2451-2454
Abstract
A xylosylated carborane was synthesized by standard carbohydrate methodology and tested on normal HFL-1 cells as well as transformed T24 cells. The xylosylated carborane initiated glycosaminoglycan (GAG) synthesis in both cell lines and treatment with the carborane gave a pronounced translocation of proteoglycans to the nuclei of T24 cells. However, most of the boron-containing compounds were secreted to the medium. We conclude that xylosides carrying carboranes are not suitable for boron neutron capture therapy (BNCT) for T24 cells. However, the uptake of boron-containing xyloside, the GAG priming capacity, and the nuclear translocation of glypican-1 make this xyloside a candidate for further investigation for selectivity toward other... (More)
A xylosylated carborane was synthesized by standard carbohydrate methodology and tested on normal HFL-1 cells as well as transformed T24 cells. The xylosylated carborane initiated glycosaminoglycan (GAG) synthesis in both cell lines and treatment with the carborane gave a pronounced translocation of proteoglycans to the nuclei of T24 cells. However, most of the boron-containing compounds were secreted to the medium. We conclude that xylosides carrying carboranes are not suitable for boron neutron capture therapy (BNCT) for T24 cells. However, the uptake of boron-containing xyloside, the GAG priming capacity, and the nuclear translocation of glypican-1 make this xyloside a candidate for further investigation for selectivity toward other tumor cell lines. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Bioorganic & Medicinal Chemistry Letters
volume
18
issue
7
pages
2451 - 2454
publisher
Elsevier
external identifiers
  • pmid:18325767
  • wos:000255246300042
  • scopus:41249087878
ISSN
1090-2120
DOI
10.1016/j.bmcl.2008.02.048
language
English
LU publication?
yes
id
ddb04f83-7700-4b29-9f02-86ef93c542aa (old id 1052767)
date added to LUP
2008-05-23 12:13:09
date last changed
2017-07-23 04:17:01
@article{ddb04f83-7700-4b29-9f02-86ef93c542aa,
  abstract     = {A xylosylated carborane was synthesized by standard carbohydrate methodology and tested on normal HFL-1 cells as well as transformed T24 cells. The xylosylated carborane initiated glycosaminoglycan (GAG) synthesis in both cell lines and treatment with the carborane gave a pronounced translocation of proteoglycans to the nuclei of T24 cells. However, most of the boron-containing compounds were secreted to the medium. We conclude that xylosides carrying carboranes are not suitable for boron neutron capture therapy (BNCT) for T24 cells. However, the uptake of boron-containing xyloside, the GAG priming capacity, and the nuclear translocation of glypican-1 make this xyloside a candidate for further investigation for selectivity toward other tumor cell lines.},
  author       = {Jacobsson, Mårten and Winander, Cecilia and Mani, Katrin and Ellervik, Ulf},
  issn         = {1090-2120},
  language     = {eng},
  number       = {7},
  pages        = {2451--2454},
  publisher    = {Elsevier},
  series       = {Bioorganic & Medicinal Chemistry Letters},
  title        = {Xylose as a carrier for boron containing compounds.},
  url          = {http://dx.doi.org/10.1016/j.bmcl.2008.02.048},
  volume       = {18},
  year         = {2008},
}