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Advances in understanding l-DOPA-induced dyskinesia.

Cenci Nilsson, Angela LU and Lindgren, Hanna LU (2007) In Current Opinion in Neurobiology 17(6). p.665-671
Abstract
The crucial role of dopamine (DA) in movement control is illustrated by the spectrum of motor disorders caused by either a deficiency or a hyperactivity of dopaminergic transmission in the basal ganglia. The degeneration of nigrostriatal DA neurons in Parkinson's disease causes poverty and slowness of movement. These symptoms are greatly improved by pharmacological DA replacement with l-3,4-dihydroxy-phenylalanine (l-DOPA), which however causes excessive involuntary movements in a majority of patients. l-DOPA-induced dyskinesia (abnormal involuntary movements) provides a topic of investigation at the interface between clinical and basic neuroscience. In this article, we review recent studies in rodent models, which have uncovered two... (More)
The crucial role of dopamine (DA) in movement control is illustrated by the spectrum of motor disorders caused by either a deficiency or a hyperactivity of dopaminergic transmission in the basal ganglia. The degeneration of nigrostriatal DA neurons in Parkinson's disease causes poverty and slowness of movement. These symptoms are greatly improved by pharmacological DA replacement with l-3,4-dihydroxy-phenylalanine (l-DOPA), which however causes excessive involuntary movements in a majority of patients. l-DOPA-induced dyskinesia (abnormal involuntary movements) provides a topic of investigation at the interface between clinical and basic neuroscience. In this article, we review recent studies in rodent models, which have uncovered two principal alterations at the basis of the movement disorder, namely, an abnormal pre-synaptic handling of exogenous l-DOPA, and a hyper-reactive post-synaptic response to DA. Dysregulated nigrostriatal DA transmission causes secondary alterations in a variety of non-dopaminergic transmitter systems, the manipulation of which modulates dyskinesia through mechanisms that are presently unclear. Further research on l-DOPA-induced dyskinesia will contribute to a deeper understanding of the functional interplay between neurotransmitters and neuromodulators in the motor circuits of the basal ganglia. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Opinion in Neurobiology
volume
17
issue
6
pages
665 - 671
publisher
Elsevier
external identifiers
  • pmid:18308560
  • wos:000255181100008
  • scopus:40749157838
ISSN
1873-6882
DOI
10.1016/j.conb.2008.01.004
language
English
LU publication?
yes
id
beaf2cdc-ca4b-4f42-ad1b-f7962985bc20 (old id 1052974)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18308560?dopt=Abstract
date added to LUP
2008-04-01 09:21:52
date last changed
2017-09-24 04:37:38
@article{beaf2cdc-ca4b-4f42-ad1b-f7962985bc20,
  abstract     = {The crucial role of dopamine (DA) in movement control is illustrated by the spectrum of motor disorders caused by either a deficiency or a hyperactivity of dopaminergic transmission in the basal ganglia. The degeneration of nigrostriatal DA neurons in Parkinson's disease causes poverty and slowness of movement. These symptoms are greatly improved by pharmacological DA replacement with l-3,4-dihydroxy-phenylalanine (l-DOPA), which however causes excessive involuntary movements in a majority of patients. l-DOPA-induced dyskinesia (abnormal involuntary movements) provides a topic of investigation at the interface between clinical and basic neuroscience. In this article, we review recent studies in rodent models, which have uncovered two principal alterations at the basis of the movement disorder, namely, an abnormal pre-synaptic handling of exogenous l-DOPA, and a hyper-reactive post-synaptic response to DA. Dysregulated nigrostriatal DA transmission causes secondary alterations in a variety of non-dopaminergic transmitter systems, the manipulation of which modulates dyskinesia through mechanisms that are presently unclear. Further research on l-DOPA-induced dyskinesia will contribute to a deeper understanding of the functional interplay between neurotransmitters and neuromodulators in the motor circuits of the basal ganglia.},
  author       = {Cenci Nilsson, Angela and Lindgren, Hanna},
  issn         = {1873-6882},
  language     = {eng},
  number       = {6},
  pages        = {665--671},
  publisher    = {Elsevier},
  series       = {Current Opinion in Neurobiology},
  title        = {Advances in understanding l-DOPA-induced dyskinesia.},
  url          = {http://dx.doi.org/10.1016/j.conb.2008.01.004},
  volume       = {17},
  year         = {2007},
}