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Retinal Function after Vitrectomy

Wallentén, Karin G; Andréasson, Sten LU and Ghosh, Fredrik LU (2008) In Retina 28(4). p.558-563
Abstract
PURPOSE:: To study retinal function after vitrectomy. METHODS:: Core vitrectomy was performed in 12 rabbits under standardized conditions using a vitreous cutting rate of either 600 or 1200 cuts/min. Full-field electroretinography (ERG) and multifocal electroretinography (mfERG) were performed pre- and postoperatively. Morphologic change was monitored by immunohistochemistry directed against glial fibrillary acidic protein (GFAP). RESULTS:: Three days postoperatively, the b-wave amplitudes of all cone and rod responses of the ERG were significantly reduced in all vitrectomized eyes. At 28 days, the rod response was still reduced, but returned to normal by 58 days. No correlation was found between vitreous cutting speed and ERG findings. No... (More)
PURPOSE:: To study retinal function after vitrectomy. METHODS:: Core vitrectomy was performed in 12 rabbits under standardized conditions using a vitreous cutting rate of either 600 or 1200 cuts/min. Full-field electroretinography (ERG) and multifocal electroretinography (mfERG) were performed pre- and postoperatively. Morphologic change was monitored by immunohistochemistry directed against glial fibrillary acidic protein (GFAP). RESULTS:: Three days postoperatively, the b-wave amplitudes of all cone and rod responses of the ERG were significantly reduced in all vitrectomized eyes. At 28 days, the rod response was still reduced, but returned to normal by 58 days. No correlation was found between vitreous cutting speed and ERG findings. No reduction in the central cone function was detected in the mfERG. GFAP upregulation was found in the entire retina of vitrectomized eyes 3 days after surgery. GFAP expression was present after 28 and 58 days in eyes in which the vitreous cutting rate had been set to 600 cuts/min, but not in the 1200 cuts/min eyes. CONCLUSION:: Pars plana vitrectomy transiently affects retinal function in rabbit eyes. Vitreous cutting speed is not related to the reduced function but appears inversely correlated to Müller cell activation, indicating that high-speed vitreous cutters are more lenient to the retina. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Miller cell, ERG, mfERG, eye
in
Retina
volume
28
issue
4
pages
558 - 563
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000255370800005
  • scopus:42549141637
ISSN
0275-004X
DOI
10.1097/IAE.0b013e31815e9890
language
English
LU publication?
no
id
58ee67da-f870-4d6d-a983-0d79ab003579 (old id 1057180)
date added to LUP
2008-04-14 11:42:29
date last changed
2017-01-01 05:38:27
@article{58ee67da-f870-4d6d-a983-0d79ab003579,
  abstract     = {PURPOSE:: To study retinal function after vitrectomy. METHODS:: Core vitrectomy was performed in 12 rabbits under standardized conditions using a vitreous cutting rate of either 600 or 1200 cuts/min. Full-field electroretinography (ERG) and multifocal electroretinography (mfERG) were performed pre- and postoperatively. Morphologic change was monitored by immunohistochemistry directed against glial fibrillary acidic protein (GFAP). RESULTS:: Three days postoperatively, the b-wave amplitudes of all cone and rod responses of the ERG were significantly reduced in all vitrectomized eyes. At 28 days, the rod response was still reduced, but returned to normal by 58 days. No correlation was found between vitreous cutting speed and ERG findings. No reduction in the central cone function was detected in the mfERG. GFAP upregulation was found in the entire retina of vitrectomized eyes 3 days after surgery. GFAP expression was present after 28 and 58 days in eyes in which the vitreous cutting rate had been set to 600 cuts/min, but not in the 1200 cuts/min eyes. CONCLUSION:: Pars plana vitrectomy transiently affects retinal function in rabbit eyes. Vitreous cutting speed is not related to the reduced function but appears inversely correlated to Müller cell activation, indicating that high-speed vitreous cutters are more lenient to the retina.},
  author       = {Wallentén, Karin G and Andréasson, Sten and Ghosh, Fredrik},
  issn         = {0275-004X},
  keyword      = {Miller cell,ERG,mfERG,eye},
  language     = {eng},
  number       = {4},
  pages        = {558--563},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Retina},
  title        = {Retinal Function after Vitrectomy},
  url          = {http://dx.doi.org/10.1097/IAE.0b013e31815e9890},
  volume       = {28},
  year         = {2008},
}