Retinal Function after Vitrectomy
(2008) In Retina 28(4). p.558-563- Abstract
- PURPOSE:: To study retinal function after vitrectomy. METHODS:: Core vitrectomy was performed in 12 rabbits under standardized conditions using a vitreous cutting rate of either 600 or 1200 cuts/min. Full-field electroretinography (ERG) and multifocal electroretinography (mfERG) were performed pre- and postoperatively. Morphologic change was monitored by immunohistochemistry directed against glial fibrillary acidic protein (GFAP). RESULTS:: Three days postoperatively, the b-wave amplitudes of all cone and rod responses of the ERG were significantly reduced in all vitrectomized eyes. At 28 days, the rod response was still reduced, but returned to normal by 58 days. No correlation was found between vitreous cutting speed and ERG findings. No... (More)
- PURPOSE:: To study retinal function after vitrectomy. METHODS:: Core vitrectomy was performed in 12 rabbits under standardized conditions using a vitreous cutting rate of either 600 or 1200 cuts/min. Full-field electroretinography (ERG) and multifocal electroretinography (mfERG) were performed pre- and postoperatively. Morphologic change was monitored by immunohistochemistry directed against glial fibrillary acidic protein (GFAP). RESULTS:: Three days postoperatively, the b-wave amplitudes of all cone and rod responses of the ERG were significantly reduced in all vitrectomized eyes. At 28 days, the rod response was still reduced, but returned to normal by 58 days. No correlation was found between vitreous cutting speed and ERG findings. No reduction in the central cone function was detected in the mfERG. GFAP upregulation was found in the entire retina of vitrectomized eyes 3 days after surgery. GFAP expression was present after 28 and 58 days in eyes in which the vitreous cutting rate had been set to 600 cuts/min, but not in the 1200 cuts/min eyes. CONCLUSION:: Pars plana vitrectomy transiently affects retinal function in rabbit eyes. Vitreous cutting speed is not related to the reduced function but appears inversely correlated to Müller cell activation, indicating that high-speed vitreous cutters are more lenient to the retina. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1057180
- author
- Wallentén, Karin G ; Andréasson, Sten LU and Ghosh, Fredrik LU
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Miller cell, ERG, mfERG, eye
- in
- Retina
- volume
- 28
- issue
- 4
- pages
- 558 - 563
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000255370800005
- scopus:42549141637
- pmid:18398357
- ISSN
- 0275-004X
- DOI
- 10.1097/IAE.0b013e31815e9890
- language
- English
- LU publication?
- no
- id
- 58ee67da-f870-4d6d-a983-0d79ab003579 (old id 1057180)
- date added to LUP
- 2016-04-01 13:23:02
- date last changed
- 2022-03-13 23:46:21
@article{58ee67da-f870-4d6d-a983-0d79ab003579,
abstract = {{PURPOSE:: To study retinal function after vitrectomy. METHODS:: Core vitrectomy was performed in 12 rabbits under standardized conditions using a vitreous cutting rate of either 600 or 1200 cuts/min. Full-field electroretinography (ERG) and multifocal electroretinography (mfERG) were performed pre- and postoperatively. Morphologic change was monitored by immunohistochemistry directed against glial fibrillary acidic protein (GFAP). RESULTS:: Three days postoperatively, the b-wave amplitudes of all cone and rod responses of the ERG were significantly reduced in all vitrectomized eyes. At 28 days, the rod response was still reduced, but returned to normal by 58 days. No correlation was found between vitreous cutting speed and ERG findings. No reduction in the central cone function was detected in the mfERG. GFAP upregulation was found in the entire retina of vitrectomized eyes 3 days after surgery. GFAP expression was present after 28 and 58 days in eyes in which the vitreous cutting rate had been set to 600 cuts/min, but not in the 1200 cuts/min eyes. CONCLUSION:: Pars plana vitrectomy transiently affects retinal function in rabbit eyes. Vitreous cutting speed is not related to the reduced function but appears inversely correlated to Müller cell activation, indicating that high-speed vitreous cutters are more lenient to the retina.}},
author = {{Wallentén, Karin G and Andréasson, Sten and Ghosh, Fredrik}},
issn = {{0275-004X}},
keywords = {{Miller cell; ERG; mfERG; eye}},
language = {{eng}},
number = {{4}},
pages = {{558--563}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Retina}},
title = {{Retinal Function after Vitrectomy}},
url = {{http://dx.doi.org/10.1097/IAE.0b013e31815e9890}},
doi = {{10.1097/IAE.0b013e31815e9890}},
volume = {{28}},
year = {{2008}},
}