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Intravitreal sustained-release ganciclovir implants for severe bilateral cytomegalovirus retinitis after stem cell transplantation.

Ghosh, Fredrik LU ; Hansson, Lars-Jörgen; Bynke, Gunnel LU and Békássy, Albert LU (2002) In Acta Ophthalmologica Scandinavica1998-01-01+01:002008-01-01+01:00 80(1). p.101-104
Abstract
Purpose: To describe the treatment of cytomegalovirus (CMV) retinitis with intravitreal sustain-release ganciclovir devices in a 16-year-old patient in third remission of acute lymphoblastic leukemia after stem cell transplantation. METHODS: The patient received a stem cell transplant from an unrelated bone marrow donor after which he contracted a serious CMV infection manifested in the lungs and retinae. His immune system at this time was almost completely depleted. Implantation of a sustained-release ganciclovir device was performed in both eyes when retinitis progressed in spite of aggressive antiviral intravenous treatment. RESULTS: No per- or postoperative complications were noted. Infiltrates, hemorrhages and macular edema present... (More)
Purpose: To describe the treatment of cytomegalovirus (CMV) retinitis with intravitreal sustain-release ganciclovir devices in a 16-year-old patient in third remission of acute lymphoblastic leukemia after stem cell transplantation. METHODS: The patient received a stem cell transplant from an unrelated bone marrow donor after which he contracted a serious CMV infection manifested in the lungs and retinae. His immune system at this time was almost completely depleted. Implantation of a sustained-release ganciclovir device was performed in both eyes when retinitis progressed in spite of aggressive antiviral intravenous treatment. RESULTS: No per- or postoperative complications were noted. Infiltrates, hemorrhages and macular edema present preoperatively dissolved over a period of six months. The final visual acuity was 1.0 in both eyes. The patients immune system and lung function slowly recovered during the same time period. CONCLUSIONS: The intravitreal ganciclovir implant provides safe and effective therapy against CMV retinitis, and should be considered in patients acquiring the infection after stem cell transplantation. (Less)
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Contribution to journal
publication status
published
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in
Acta Ophthalmologica Scandinavica1998-01-01+01:002008-01-01+01:00
volume
80
issue
1
pages
101 - 104
publisher
Wiley-Blackwell
external identifiers
  • pmid:11906315
  • wos:000174388300021
  • scopus:0036250164
ISSN
1395-3907
DOI
10.1034/j.1600-0420.2002.800121.x
language
English
LU publication?
yes
id
4bb42d28-3e76-44d1-8138-9779994f72c0 (old id 105857)
alternative location
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=11906315&dopt=Abstract
date added to LUP
2007-07-09 09:06:16
date last changed
2017-01-01 07:02:13
@article{4bb42d28-3e76-44d1-8138-9779994f72c0,
  abstract     = {Purpose: To describe the treatment of cytomegalovirus (CMV) retinitis with intravitreal sustain-release ganciclovir devices in a 16-year-old patient in third remission of acute lymphoblastic leukemia after stem cell transplantation. METHODS: The patient received a stem cell transplant from an unrelated bone marrow donor after which he contracted a serious CMV infection manifested in the lungs and retinae. His immune system at this time was almost completely depleted. Implantation of a sustained-release ganciclovir device was performed in both eyes when retinitis progressed in spite of aggressive antiviral intravenous treatment. RESULTS: No per- or postoperative complications were noted. Infiltrates, hemorrhages and macular edema present preoperatively dissolved over a period of six months. The final visual acuity was 1.0 in both eyes. The patients immune system and lung function slowly recovered during the same time period. CONCLUSIONS: The intravitreal ganciclovir implant provides safe and effective therapy against CMV retinitis, and should be considered in patients acquiring the infection after stem cell transplantation.},
  author       = {Ghosh, Fredrik and Hansson, Lars-Jörgen and Bynke, Gunnel and Békássy, Albert},
  issn         = {1395-3907},
  language     = {eng},
  number       = {1},
  pages        = {101--104},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Ophthalmologica Scandinavica1998-01-01+01:002008-01-01+01:00},
  title        = {Intravitreal sustained-release ganciclovir implants for severe bilateral cytomegalovirus retinitis after stem cell transplantation.},
  url          = {http://dx.doi.org/10.1034/j.1600-0420.2002.800121.x},
  volume       = {80},
  year         = {2002},
}