Interleukin-1 receptor antagonist is detectable in human carotid artery plaques and is related to triglyceride levels and Chlamydia pneumoniae IgA antibodies.

Gottsäter, Anders; Forsblad, J; Mätzsch, Thomas; Persson, K; Ljungcrantz, Irena; Ohlsson, K; Lindgärde, Folke

Interleukin-1 receptor antagonist is detectable in human carotid artery plaques and is related to triglyceride levels and Chlamydia pneumoniae IgA antibodies.

Mark

Gottsäter, Anders ^LU ; Forsblad, J ; Mätzsch, Thomas ^LU ; Persson, K ; Ljungcrantz, Irena ^LU ; Ohlsson, K and Lindgärde, Folke ^LU (2002) In Journal of Internal Medicine 251(1). p.61-68

Abstract: OBJECTIVES: To investigate whether the interleukin-1 receptor antagonist (Il-1ra) and interleukin-1beta (Il-1beta) can be detected in human carotid artery tissue, and whether their presence is related to evidence of Chlamydia pneumoniae infection, risk factors for atherosclerosis, and clinical data. SETTING: Departments of Vascular Diseases and Surgical Pathophysiology, University Hospital, Malmö, Sweden. SUBJECTS: A total of 66 patients undergoing carotid endarterectomy (median age 74, range 53-89 years, 26 women). Il-1beta and Il-1ra were studied in carotid artery plaques and in Il-1ra in serum. RESULTS: Interleukin-1 receptor antagonist was detected in mononuclear cells in plaques from 37/66 (56%) patients. Patients with Il-1ra in... (More); OBJECTIVES: To investigate whether the interleukin-1 receptor antagonist (Il-1ra) and interleukin-1beta (Il-1beta) can be detected in human carotid artery tissue, and whether their presence is related to evidence of Chlamydia pneumoniae infection, risk factors for atherosclerosis, and clinical data. SETTING: Departments of Vascular Diseases and Surgical Pathophysiology, University Hospital, Malmö, Sweden. SUBJECTS: A total of 66 patients undergoing carotid endarterectomy (median age 74, range 53-89 years, 26 women). Il-1beta and Il-1ra were studied in carotid artery plaques and in Il-1ra in serum. RESULTS: Interleukin-1 receptor antagonist was detected in mononuclear cells in plaques from 37/66 (56%) patients. Patients with Il-1ra in plaques showed higher [2.04 (1.70-3.14) mmol x L(-1) vs. 1.69 (1.09-1.99) mmol x L(-1); P < 0.05] serum(s-)triglyceride(tg) levels, and a higher frequency of IgA seropositivity for C. pneumoniae (76% vs. 52%; P < 0.05) than those without. S-Il-1ra levels correlated with s-tg levels (r=0.38; P=0.047). There were no differences between patients with and without Il-1ra in plaques concerning s-Il-1ra, blood(b-)haemoglobin or leucocyte count, s-cholesterol, b-glucose, blood pressure, IgG seropositivity for C. pneumoniae, prevalence of neurological symptoms preceding operation, smoking, or diabetes mellitus. There were no differences in frequency of Il-1ra in plaques or in s-Il-1ra levels between patients with symptomatic and asymptomatic stenosis, between smokers and nonsmokers, or between diabetic and nondiabetic patients. Il-1beta was not detected in plaques in the current study. CONCLUSION: Interleukin-1 receptor antagonist can be detected in human atherosclerotic carotid artery plaques, and is related to s-triglyceride levels and IgA seropositivity for C. pneumoniae, but not to prevalence of neurological symptoms related to embolization. (Less)

Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/105910

author

Gottsäter, Anders ^LU ; Forsblad, J ; Mätzsch, Thomas ^LU ; Persson, K ; Ljungcrantz, Irena ^LU ; Ohlsson, K and Lindgärde, Folke ^LU

organization

publishing date

2002

type

Contribution to journal

publication status

published

subject

keywords

Sialoglycoproteins, Interleukin-1, Immunoglobulin A, Enzyme-Linked Immunosorbent Assay, Therapy, Metabolism, Immunology, Carotid Artery Diseases, Statistics, Nonparametric

in

Journal of Internal Medicine

volume

251

issue

1

pages

61 - 68

publisher

Wiley-Blackwell

external identifiers

wos:000173204400007
pmid:11851866
scopus:0036200645

ISSN

1365-2796

DOI

10.1046/j.1365-2796.2002.00926.x

language

English

LU publication?

yes

additional info

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Unit for Clinical Vascular Disease Research (013242410), Emergency medicine/Medicine/Surgery (013240200), Clinical Microbiology, Malmö (013011000), Experimental Cardiovascular Research Unit (013242110)

id

7554417f-b633-4781-a84e-fc9e003b80c5 (old id 105910)

alternative location

http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11851866&dopt=Abstract

date added to LUP

2016-04-01 15:48:22

date last changed

2022-01-28 07:11:28

@article{7554417f-b633-4781-a84e-fc9e003b80c5,
  abstract     = {{OBJECTIVES: To investigate whether the interleukin-1 receptor antagonist (Il-1ra) and interleukin-1beta (Il-1beta) can be detected in human carotid artery tissue, and whether their presence is related to evidence of Chlamydia pneumoniae infection, risk factors for atherosclerosis, and clinical data. SETTING: Departments of Vascular Diseases and Surgical Pathophysiology, University Hospital, Malmö, Sweden. SUBJECTS: A total of 66 patients undergoing carotid endarterectomy (median age 74, range 53-89 years, 26 women). Il-1beta and Il-1ra were studied in carotid artery plaques and in Il-1ra in serum. RESULTS: Interleukin-1 receptor antagonist was detected in mononuclear cells in plaques from 37/66 (56%) patients. Patients with Il-1ra in plaques showed higher [2.04 (1.70-3.14) mmol x L(-1) vs. 1.69 (1.09-1.99) mmol x L(-1); P &lt; 0.05] serum(s-)triglyceride(tg) levels, and a higher frequency of IgA seropositivity for C. pneumoniae (76% vs. 52%; P &lt; 0.05) than those without. S-Il-1ra levels correlated with s-tg levels (r=0.38; P=0.047). There were no differences between patients with and without Il-1ra in plaques concerning s-Il-1ra, blood(b-)haemoglobin or leucocyte count, s-cholesterol, b-glucose, blood pressure, IgG seropositivity for C. pneumoniae, prevalence of neurological symptoms preceding operation, smoking, or diabetes mellitus. There were no differences in frequency of Il-1ra in plaques or in s-Il-1ra levels between patients with symptomatic and asymptomatic stenosis, between smokers and nonsmokers, or between diabetic and nondiabetic patients. Il-1beta was not detected in plaques in the current study. CONCLUSION: Interleukin-1 receptor antagonist can be detected in human atherosclerotic carotid artery plaques, and is related to s-triglyceride levels and IgA seropositivity for C. pneumoniae, but not to prevalence of neurological symptoms related to embolization.}},
  author       = {{Gottsäter, Anders and Forsblad, J and Mätzsch, Thomas and Persson, K and Ljungcrantz, Irena and Ohlsson, K and Lindgärde, Folke}},
  issn         = {{1365-2796}},
  keywords     = {{Sialoglycoproteins; Interleukin-1; Immunoglobulin A; Enzyme-Linked Immunosorbent Assay; Therapy; Metabolism; Immunology; Carotid Artery Diseases; Statistics; Nonparametric}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{61--68}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Journal of Internal Medicine}},
  title        = {{Interleukin-1 receptor antagonist is detectable in human carotid artery plaques and is related to triglyceride levels and Chlamydia pneumoniae IgA antibodies.}},
  url          = {{http://dx.doi.org/10.1046/j.1365-2796.2002.00926.x}},
  doi          = {{10.1046/j.1365-2796.2002.00926.x}},
  volume       = {{251}},
  year         = {{2002}},
}

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Interleukin-1 receptor antagonist is detectable in human carotid artery plaques and is related to triglyceride levels and Chlamydia pneumoniae IgA antibodies.