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Neuropathology of white matter lesions in vascular cognitive impairment.

Englund, Elisabet LU (2002) In Cerebrovascular Diseases 13 Suppl 2(Suppl 2). p.11-15
Abstract
The white matter is an important locus for tissue damage in vascular cognitive impairment and white matter lesions often dominate over gray matter changes. The spectrum of ischemic white matter lesions histopathologically represents focal and diffuse lesions, the most common form being the combination of both, in varying proportions. In the combined pathology, the diffuse lesion represents a gradient zone of damage towards surrounding normal tissue and may hold over 200 times the volume of an identified focal lesion, the lacunar infarct. Pathogenetically, the focal lesion results from the acute reaction to regional ischemia, while the diffuse white matter lesion represents the adjustment to altered perfusional and physiological conditions... (More)
The white matter is an important locus for tissue damage in vascular cognitive impairment and white matter lesions often dominate over gray matter changes. The spectrum of ischemic white matter lesions histopathologically represents focal and diffuse lesions, the most common form being the combination of both, in varying proportions. In the combined pathology, the diffuse lesion represents a gradient zone of damage towards surrounding normal tissue and may hold over 200 times the volume of an identified focal lesion, the lacunar infarct. Pathogenetically, the focal lesion results from the acute reaction to regional ischemia, while the diffuse white matter lesion represents the adjustment to altered perfusional and physiological conditions within the tissue. Copyright 2002 S. Karger AG, Basel (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Pathology, Brain Infarction/pathology, Brain, Dementia, Brain Ischemia/pathology
in
Cerebrovascular Diseases
volume
13 Suppl 2
issue
Suppl 2
pages
11 - 15
publisher
Karger
external identifiers
  • wos:000174794200003
  • scopus:0036128625
ISSN
1421-9786
DOI
10.1159/000049144
language
English
LU publication?
yes
id
6f8cfa1b-d24b-48a2-9d77-ad3ad409e39d (old id 105919)
alternative location
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11901237&dopt=Abstract
date added to LUP
2007-07-19 14:50:57
date last changed
2017-07-02 03:35:54
@article{6f8cfa1b-d24b-48a2-9d77-ad3ad409e39d,
  abstract     = {The white matter is an important locus for tissue damage in vascular cognitive impairment and white matter lesions often dominate over gray matter changes. The spectrum of ischemic white matter lesions histopathologically represents focal and diffuse lesions, the most common form being the combination of both, in varying proportions. In the combined pathology, the diffuse lesion represents a gradient zone of damage towards surrounding normal tissue and may hold over 200 times the volume of an identified focal lesion, the lacunar infarct. Pathogenetically, the focal lesion results from the acute reaction to regional ischemia, while the diffuse white matter lesion represents the adjustment to altered perfusional and physiological conditions within the tissue. Copyright 2002 S. Karger AG, Basel},
  author       = {Englund, Elisabet},
  issn         = {1421-9786},
  keyword      = {Pathology,Brain Infarction/pathology,Brain,Dementia,Brain Ischemia/pathology},
  language     = {eng},
  number       = {Suppl 2},
  pages        = {11--15},
  publisher    = {Karger},
  series       = {Cerebrovascular Diseases},
  title        = {Neuropathology of white matter lesions in vascular cognitive impairment.},
  url          = {http://dx.doi.org/10.1159/000049144},
  volume       = {13 Suppl 2},
  year         = {2002},
}