New directions for erectile dysfunction therapies.
Andersson, Karl-Erik LU
and Hedlund, Petter
LU
(2002)
In International Journal of Impotence Research
14 Suppl 1.
p.82-92
- Abstract
- Research in the field of erectile function and dysfunction has continued to expand rapidly. Based on the information available, some directions for future erectile dysfunction therapies can be identified. The first direction is improvement of current therapeutic principles. A second generation of orally active phosphodiesterase (PDE) inhibitors is being introduced, and further developments within this field can be expected. The recent introduction of apomorphine has opened the way for new dopamine receptor agonists. The second direction is combinations of existing therapeutic principles. Combinations of apomorphine and sildenafil and apomorphine and alpha(1)-adrenoceptor (AR) antagonists, for example, seem attractive and may have a... (More)
- Research in the field of erectile function and dysfunction has continued to expand rapidly. Based on the information available, some directions for future erectile dysfunction therapies can be identified. The first direction is improvement of current therapeutic principles. A second generation of orally active phosphodiesterase (PDE) inhibitors is being introduced, and further developments within this field can be expected. The recent introduction of apomorphine has opened the way for new dopamine receptor agonists. The second direction is combinations of existing therapeutic principles. Combinations of apomorphine and sildenafil and apomorphine and alpha(1)-adrenoceptor (AR) antagonists, for example, seem attractive and may have a therapeutic potential in patients not responding satisfactorily to single-drug treatment. Nitrosylated alpha(1)-AR antagonists, combining nitric oxide donation and alpha(1)- or alpha(2)-AR antagonism, are currently being evaluated. The third direction is new targets within the central nervous system. Melanocortin receptor agonists have shown promise not only in animal models, but also in preliminary studies in humans. Other possible targets, such as growth hormone-releasing peptide receptors, are being explored. The fourth direction is new peripheral targets. Rho-kinase antagonism and non-nitric oxide-mediated stimulation of soluble guanylyl cyclase have been suggested as possible new principles for drug development. The fourth direction is gene therapy. Progress has been made in intracavernosal somatic gene therapy and will probably continue. Still, problems remain, and advantages over conventional pharmacological therapies have to be demonstrated. The final direction is prevention strategies. Strategies to prevent cavernosal degeneration and/or to restore cavernosal function will be one of the most exciting challenges for future research. DOI: 10.1038/sj/ijir/3900797 (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/105930
- author
- Andersson, Karl-Erik
LU
and Hedlund, Petter
LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Apomorphine, Dopamine Agonists, Phosphodiesterase Inhibitors, Central Nervous System
- in
- International Journal of Impotence Research
- volume
- 14 Suppl 1
- pages
- 82 - 92
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000174071500025
- scopus:0036194396
- ISSN
- 1476-5489
- DOI
- 10.1038/sj/ijir/3900797
- language
- English
- LU publication?
- yes
- id
- 87392040-322b-46e2-8830-db1761621382 (old id 105930)
- date added to LUP
- 2016-04-01 12:00:27
- date last changed
- 2022-02-11 00:42:19
@article{87392040-322b-46e2-8830-db1761621382,
abstract = {{Research in the field of erectile function and dysfunction has continued to expand rapidly. Based on the information available, some directions for future erectile dysfunction therapies can be identified. The first direction is improvement of current therapeutic principles. A second generation of orally active phosphodiesterase (PDE) inhibitors is being introduced, and further developments within this field can be expected. The recent introduction of apomorphine has opened the way for new dopamine receptor agonists. The second direction is combinations of existing therapeutic principles. Combinations of apomorphine and sildenafil and apomorphine and alpha(1)-adrenoceptor (AR) antagonists, for example, seem attractive and may have a therapeutic potential in patients not responding satisfactorily to single-drug treatment. Nitrosylated alpha(1)-AR antagonists, combining nitric oxide donation and alpha(1)- or alpha(2)-AR antagonism, are currently being evaluated. The third direction is new targets within the central nervous system. Melanocortin receptor agonists have shown promise not only in animal models, but also in preliminary studies in humans. Other possible targets, such as growth hormone-releasing peptide receptors, are being explored. The fourth direction is new peripheral targets. Rho-kinase antagonism and non-nitric oxide-mediated stimulation of soluble guanylyl cyclase have been suggested as possible new principles for drug development. The fourth direction is gene therapy. Progress has been made in intracavernosal somatic gene therapy and will probably continue. Still, problems remain, and advantages over conventional pharmacological therapies have to be demonstrated. The final direction is prevention strategies. Strategies to prevent cavernosal degeneration and/or to restore cavernosal function will be one of the most exciting challenges for future research. DOI: 10.1038/sj/ijir/3900797}},
author = {{Andersson, Karl-Erik and Hedlund, Petter}},
issn = {{1476-5489}},
keywords = {{Apomorphine; Dopamine Agonists; Phosphodiesterase Inhibitors; Central Nervous System}},
language = {{eng}},
pages = {{82--92}},
publisher = {{Nature Publishing Group}},
series = {{International Journal of Impotence Research}},
title = {{New directions for erectile dysfunction therapies.}},
url = {{http://dx.doi.org/10.1038/sj/ijir/3900797}},
doi = {{10.1038/sj/ijir/3900797}},
volume = {{14 Suppl 1}},
year = {{2002}},
}