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Quantification of myocardial hypoperfusion with 99m Tc-sestamibi in patients undergoing prolonged coronary artery balloon occlusion.

Persson, Eva LU ; Palmer, John LU ; Pettersson, J.; Warren, S.; Borges-Neto, S.; Wagner, G. and Pahlm, O. (2002) In Nuclear Medicine Communications 23(3). p.219-228
Abstract
SUMMARY: Percutaneous transluminal coronary angioplasty provides an excellent opportunity to investigate the location and quantity of hypoperfusion during sudden complete occlusion of one of the major coronary arteries. Thirty-five patients referred for elective percutaneous transluminal coronary angioplasty were injected intravenously with 99mTc-sestamibi during balloon inflation. To visualize and quantify the hypoperfused region, a map of perfusion was constructed from that occlusion study and from the control study performed on the following day. Patients were divided into groups according to proximal or distal occlusion within each of the three coronary arteries. The region of myocardium supplied by each coronary artery varied in... (More)
SUMMARY: Percutaneous transluminal coronary angioplasty provides an excellent opportunity to investigate the location and quantity of hypoperfusion during sudden complete occlusion of one of the major coronary arteries. Thirty-five patients referred for elective percutaneous transluminal coronary angioplasty were injected intravenously with 99mTc-sestamibi during balloon inflation. To visualize and quantify the hypoperfused region, a map of perfusion was constructed from that occlusion study and from the control study performed on the following day. Patients were divided into groups according to proximal or distal occlusion within each of the three coronary arteries. The region of myocardium supplied by each coronary artery varied in location and extended outside the typical borders for all arteries, but most prominently for the left circumflex coronary artery. The quantities of hypoperfusion varied within each artery group, but the average hypoperfusion was greater for the left anterior descending coronary artery than for either the right coronary artery or the left circumflex coronary artery. It is concluded that the quantities of hypoperfusion were highly variable within each artery group. Occlusion of the left anterior descending coronary artery was associated with the largest ischaemic region. The area of hypoperfusion extended outside the typical borders, most prominently for the left circumflex coronary artery. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Nuclear Medicine Communications
volume
23
issue
3
pages
219 - 228
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:11891479
  • wos:000174534300004
ISSN
1473-5628
language
English
LU publication?
yes
id
4e254bca-3cd7-41be-8c40-4e7413c2f6a9 (old id 106042)
alternative location
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11891479&dopt=Abstract
date added to LUP
2007-07-17 14:42:21
date last changed
2016-04-15 20:41:05
@article{4e254bca-3cd7-41be-8c40-4e7413c2f6a9,
  abstract     = {SUMMARY: Percutaneous transluminal coronary angioplasty provides an excellent opportunity to investigate the location and quantity of hypoperfusion during sudden complete occlusion of one of the major coronary arteries. Thirty-five patients referred for elective percutaneous transluminal coronary angioplasty were injected intravenously with 99mTc-sestamibi during balloon inflation. To visualize and quantify the hypoperfused region, a map of perfusion was constructed from that occlusion study and from the control study performed on the following day. Patients were divided into groups according to proximal or distal occlusion within each of the three coronary arteries. The region of myocardium supplied by each coronary artery varied in location and extended outside the typical borders for all arteries, but most prominently for the left circumflex coronary artery. The quantities of hypoperfusion varied within each artery group, but the average hypoperfusion was greater for the left anterior descending coronary artery than for either the right coronary artery or the left circumflex coronary artery. It is concluded that the quantities of hypoperfusion were highly variable within each artery group. Occlusion of the left anterior descending coronary artery was associated with the largest ischaemic region. The area of hypoperfusion extended outside the typical borders, most prominently for the left circumflex coronary artery.},
  author       = {Persson, Eva and Palmer, John and Pettersson, J. and Warren, S. and Borges-Neto, S. and Wagner, G. and Pahlm, O.},
  issn         = {1473-5628},
  language     = {eng},
  number       = {3},
  pages        = {219--228},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Nuclear Medicine Communications},
  title        = {Quantification of myocardial hypoperfusion with 99m Tc-sestamibi in patients undergoing prolonged coronary artery balloon occlusion.},
  volume       = {23},
  year         = {2002},
}