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Enhanced vasodilator responses to calcitonin gene-related peptide (CGRP) in subcutaneous arteries in human hypertension.

Lind, H and Edvinsson, Lars LU (2002) In Journal of Human Hypertension 16(1). p.53-59
Abstract
Isolated segments (1-2 mm) of small subcutaneous arteries (diameter 0.1-0.9 mm) and veins (0.1-1.0 mm) from patients with hypertension (essential n = 13, renovascular n = 6) and controls (n = 17) were examined. The relaxant responses to the sensory transmitters calcitonin gene-related peptide (CGRP) and substance P, and the contractile responses to potassium and noradrenaline were studied. Enhanced dilatory responses (E(max)) but no change in sensitivity (pEC50) were demonstrated in the arteries but not in the veins to CGRP in hypertensives (P < 0.01) as compared with normotensives, and in the hypertensive subgroups (essential hypertension, P < 0.05; renovascular hypertension, P< 0.05). The relaxant responses to substance P were... (More)
Isolated segments (1-2 mm) of small subcutaneous arteries (diameter 0.1-0.9 mm) and veins (0.1-1.0 mm) from patients with hypertension (essential n = 13, renovascular n = 6) and controls (n = 17) were examined. The relaxant responses to the sensory transmitters calcitonin gene-related peptide (CGRP) and substance P, and the contractile responses to potassium and noradrenaline were studied. Enhanced dilatory responses (E(max)) but no change in sensitivity (pEC50) were demonstrated in the arteries but not in the veins to CGRP in hypertensives (P < 0.01) as compared with normotensives, and in the hypertensive subgroups (essential hypertension, P < 0.05; renovascular hypertension, P< 0.05). The relaxant responses to substance P were not altered either in arteries or in veins of hypertensives. Furthermore, there were no differences in the contractile responses to 60 mM potassium or to 10 microM noradrenaline between the groups. The results suggest that the enhanced vasodilator response to CGRP in hypertension is an adaptive reaction. The elevated blood pressure may be augmented by vasodilatory activity since different subgroups of hypertensives showed the same results. However, other common characteristics of hypertension (eg, medication, metabolic disturbances) may have also influenced the results. (Less)
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keywords
Human, Middle Age, Male, Hypertension/*physiopathology, Muscle, Smooth/drug effects/physiopathology, Neuromuscular Depolarizing Agents/pharmacology, Norepinephrine/pharmacology, Potassium/pharmacology, Skin/*blood supply/drug effects/*physiopathology, Substance P/*pharmacology, Support, Non-U.S. Gov't, Vasoconstrictor Agents/pharmacology, Vasodilation/*drug effects/*physiology, Veins/*drug effects/*physiopathology, Vasomotor System/drug effects/physiopathology, Female, Calcitonin Gene-Related Peptide/*pharmacology, Arteries/*drug effects/*physiopathology
in
Journal of Human Hypertension
volume
16
issue
1
pages
53 - 59
publisher
Nature Publishing Group
external identifiers
  • pmid:11840230
  • wos:000173900500008
  • scopus:0036166444
ISSN
1476-5527
DOI
10.1038/sj/jhh/1001294
language
English
LU publication?
yes
id
0e966a66-dfa9-4fb5-8f29-694f53bb0e38 (old id 106062)
alternative location
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11840230&dopt=Abstract
date added to LUP
2007-06-29 12:18:42
date last changed
2017-01-01 04:38:05
@article{0e966a66-dfa9-4fb5-8f29-694f53bb0e38,
  abstract     = {Isolated segments (1-2 mm) of small subcutaneous arteries (diameter 0.1-0.9 mm) and veins (0.1-1.0 mm) from patients with hypertension (essential n = 13, renovascular n = 6) and controls (n = 17) were examined. The relaxant responses to the sensory transmitters calcitonin gene-related peptide (CGRP) and substance P, and the contractile responses to potassium and noradrenaline were studied. Enhanced dilatory responses (E(max)) but no change in sensitivity (pEC50) were demonstrated in the arteries but not in the veins to CGRP in hypertensives (P &lt; 0.01) as compared with normotensives, and in the hypertensive subgroups (essential hypertension, P &lt; 0.05; renovascular hypertension, P&lt; 0.05). The relaxant responses to substance P were not altered either in arteries or in veins of hypertensives. Furthermore, there were no differences in the contractile responses to 60 mM potassium or to 10 microM noradrenaline between the groups. The results suggest that the enhanced vasodilator response to CGRP in hypertension is an adaptive reaction. The elevated blood pressure may be augmented by vasodilatory activity since different subgroups of hypertensives showed the same results. However, other common characteristics of hypertension (eg, medication, metabolic disturbances) may have also influenced the results.},
  author       = {Lind, H and Edvinsson, Lars},
  issn         = {1476-5527},
  keyword      = {Human,Middle Age,Male,Hypertension/*physiopathology,Muscle,Smooth/drug effects/physiopathology,Neuromuscular Depolarizing Agents/pharmacology,Norepinephrine/pharmacology,Potassium/pharmacology,Skin/*blood supply/drug effects/*physiopathology,Substance P/*pharmacology,Support,Non-U.S. Gov't,Vasoconstrictor Agents/pharmacology,Vasodilation/*drug effects/*physiology,Veins/*drug effects/*physiopathology,Vasomotor System/drug effects/physiopathology,Female,Calcitonin Gene-Related Peptide/*pharmacology,Arteries/*drug effects/*physiopathology},
  language     = {eng},
  number       = {1},
  pages        = {53--59},
  publisher    = {Nature Publishing Group},
  series       = {Journal of Human Hypertension},
  title        = {Enhanced vasodilator responses to calcitonin gene-related peptide (CGRP) in subcutaneous arteries in human hypertension.},
  url          = {http://dx.doi.org/10.1038/sj/jhh/1001294},
  volume       = {16},
  year         = {2002},
}