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Multiparameter analyses of cell cycle regulatory proteins in human breast cancer: a key to definition of separate pathways in tumorigenesis.

Landberg, Göran LU (2002) In Adv Cancer Res 84. p.35-56
Abstract
Breast cancer is one of the most common cancer forms affecting many women. The disease nevertheless has widely varying behavior and therefore patient outcome, and an important undertaking is to define and understand the molecular mechanisms behind these actions. Defects in the G1/S transition in the cell cycle affect both tumor proliferation and the fidelity of check points responsible for chromosomal integrity and DNA damage response and has lately been shown to represent one of a rather limited set of key aberrations in the transformation process. Many cell cycle regulatory proteins are either oncogenes or suppressor genes or are closely associated to the transformation process. The types of aberrations in the G1/S transition seem to be... (More)
Breast cancer is one of the most common cancer forms affecting many women. The disease nevertheless has widely varying behavior and therefore patient outcome, and an important undertaking is to define and understand the molecular mechanisms behind these actions. Defects in the G1/S transition in the cell cycle affect both tumor proliferation and the fidelity of check points responsible for chromosomal integrity and DNA damage response and has lately been shown to represent one of a rather limited set of key aberrations in the transformation process. Many cell cycle regulatory proteins are either oncogenes or suppressor genes or are closely associated to the transformation process. The types of aberrations in the G1/S transition seem to be different in various cancers but are nevertheless often linked to clinical behaviors. In this review the role of multiparameter analyses of cell cycle regulatory proteins in breast cancer will be outlined with special attention to pattern analyses as well as the definition of two contrasting pathways in tumorigenesis defined by either cyclin D1 or cyclin F overexpression. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Human, G1 Phase, S Phase, *Cell Cycle, Breast Neoplasms/genetics/*metabolism, Cyclin D1/*biosynthesis, Cyclin-Dependent Kinases/*antagonists & inhibitors, Cyclin E/*biosynthesis, Non-U.S. Gov't, Support
in
Adv Cancer Res
volume
84
pages
35 - 56
publisher
Elsevier
external identifiers
  • wos:000174461900002
  • pmid:11883531
  • scopus:0036188030
ISSN
0065-230X
ISBN
978-0-12-006684-1
DOI
10.1016/S0065-230X(02)84002-7
language
English
LU publication?
yes
id
06d284bb-fb6a-4cc7-a6dd-38067af61078 (old id 106193)
date added to LUP
2007-08-10 12:46:03
date last changed
2017-01-01 06:54:25
@inbook{06d284bb-fb6a-4cc7-a6dd-38067af61078,
  abstract     = {Breast cancer is one of the most common cancer forms affecting many women. The disease nevertheless has widely varying behavior and therefore patient outcome, and an important undertaking is to define and understand the molecular mechanisms behind these actions. Defects in the G1/S transition in the cell cycle affect both tumor proliferation and the fidelity of check points responsible for chromosomal integrity and DNA damage response and has lately been shown to represent one of a rather limited set of key aberrations in the transformation process. Many cell cycle regulatory proteins are either oncogenes or suppressor genes or are closely associated to the transformation process. The types of aberrations in the G1/S transition seem to be different in various cancers but are nevertheless often linked to clinical behaviors. In this review the role of multiparameter analyses of cell cycle regulatory proteins in breast cancer will be outlined with special attention to pattern analyses as well as the definition of two contrasting pathways in tumorigenesis defined by either cyclin D1 or cyclin F overexpression.},
  author       = {Landberg, Göran},
  isbn         = {978-0-12-006684-1},
  issn         = {0065-230X},
  keyword      = {Human,G1 Phase,S Phase,*Cell Cycle,Breast Neoplasms/genetics/*metabolism,Cyclin D1/*biosynthesis,Cyclin-Dependent Kinases/*antagonists & inhibitors,Cyclin E/*biosynthesis,Non-U.S. Gov't,Support},
  language     = {eng},
  pages        = {35--56},
  publisher    = {Elsevier},
  series       = {Adv Cancer Res},
  title        = {Multiparameter analyses of cell cycle regulatory proteins in human breast cancer: a key to definition of separate pathways in tumorigenesis.},
  url          = {http://dx.doi.org/10.1016/S0065-230X(02)84002-7},
  volume       = {84},
  year         = {2002},
}