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In vitro and in vivo aspects of quantifying intrapulmonary deposition of a dry powder radioaerosol.

Bondesson, Eva LU ; Asking, Lars; Borgström, Lars; Nilsson, Lars-Erik; Trofast, Eva and Wollmer, Per LU (2002) In International Journal of Pharmaceutics 232(1-2). p.149-156
Abstract
Pulmonary delivery of pharmaceutical aerosols can be quantified using gamma scintigraphy. Technetium-99m, the most commonly used radionuclide in scintigraphic studies, cannot be incorporated into the drug molecule and, therefore, may be distributed differently from the drug itself, particularly if the drug is presented as a solid in a liquid suspension or as a dry powder formulation. This study demonstrated the importance of using conditions relevant to the in vivo situation in the in vitro characterisation of a dry powder aerosol of 99mTc-labelled lactose. The influence of inspiratory flow on the distribution of aerosol within the lungs was investigated in eight healthy subjects who inhaled the 99mTc-labelled lactose at four flows... (More)
Pulmonary delivery of pharmaceutical aerosols can be quantified using gamma scintigraphy. Technetium-99m, the most commonly used radionuclide in scintigraphic studies, cannot be incorporated into the drug molecule and, therefore, may be distributed differently from the drug itself, particularly if the drug is presented as a solid in a liquid suspension or as a dry powder formulation. This study demonstrated the importance of using conditions relevant to the in vivo situation in the in vitro characterisation of a dry powder aerosol of 99mTc-labelled lactose. The influence of inspiratory flow on the distribution of aerosol within the lungs was investigated in eight healthy subjects who inhaled the 99mTc-labelled lactose at four flows (30,40,60 and 80 l/min). No differences in penetration index (PI) or count density distribution of radioactivity were seen, indicating that regional distribution of aerosol in healthy airways was insensitive to differences in the inspiratory effort exerted by the subject while inhaling the experimental dry powder radioaerosol. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cross-Over Studies, Human, Lactose : administration & dosage : pharmacokinetics, Lung : metabolism : radionuclide imaging, Male, Tissue Distribution, Powders, Technetium, Administration Inhalation, Adult, Analysis of Variance
in
International Journal of Pharmaceutics
volume
232
issue
1-2
pages
149 - 156
publisher
Elsevier
external identifiers
  • pmid:11790498
  • wos:000173676400014
  • scopus:0037203699
ISSN
1873-3476
DOI
10.1016/S0378-5173(01)00898-5
language
English
LU publication?
yes
id
fdd60325-5519-4672-ac7d-09b9130fdf30 (old id 106679)
alternative location
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11790498&dopt=Abstract
date added to LUP
2007-07-16 09:55:23
date last changed
2017-01-01 05:05:47
@article{fdd60325-5519-4672-ac7d-09b9130fdf30,
  abstract     = {Pulmonary delivery of pharmaceutical aerosols can be quantified using gamma scintigraphy. Technetium-99m, the most commonly used radionuclide in scintigraphic studies, cannot be incorporated into the drug molecule and, therefore, may be distributed differently from the drug itself, particularly if the drug is presented as a solid in a liquid suspension or as a dry powder formulation. This study demonstrated the importance of using conditions relevant to the in vivo situation in the in vitro characterisation of a dry powder aerosol of 99mTc-labelled lactose. The influence of inspiratory flow on the distribution of aerosol within the lungs was investigated in eight healthy subjects who inhaled the 99mTc-labelled lactose at four flows (30,40,60 and 80 l/min). No differences in penetration index (PI) or count density distribution of radioactivity were seen, indicating that regional distribution of aerosol in healthy airways was insensitive to differences in the inspiratory effort exerted by the subject while inhaling the experimental dry powder radioaerosol.},
  author       = {Bondesson, Eva and Asking, Lars and Borgström, Lars and Nilsson, Lars-Erik and Trofast, Eva and Wollmer, Per},
  issn         = {1873-3476},
  keyword      = {Cross-Over Studies,Human,Lactose : administration & dosage : pharmacokinetics,Lung : metabolism : radionuclide imaging,Male,Tissue Distribution,Powders,Technetium,Administration Inhalation,Adult,Analysis of Variance},
  language     = {eng},
  number       = {1-2},
  pages        = {149--156},
  publisher    = {Elsevier},
  series       = {International Journal of Pharmaceutics},
  title        = {In vitro and in vivo aspects of quantifying intrapulmonary deposition of a dry powder radioaerosol.},
  url          = {http://dx.doi.org/10.1016/S0378-5173(01)00898-5},
  volume       = {232},
  year         = {2002},
}