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Gut Microbiome Composition in Dystonia Patients

Timmers, Elze R ; Swarte, J Casper ; Gacesa, Ranko ; Björk, Johannes R ; Weersma, Rinse K ; Tijssen, Marina A J ; de Koning, Tom J LU ; Harmsen, Hermie J M and Niezen-Koning, Klary E (2023) In International Journal of Molecular Sciences 24(3). p.1-15
Abstract

Dystonia is a movement disorder in which patients have involuntary abnormal movements or postures. Non-motor symptoms, such as psychiatric symptoms, sleep problems and fatigue, are common. We hypothesise that the gut microbiome might play a role in the pathophysiology of the (non-)motor symptoms in dystonia via the gut-brain axis. This exploratory study investigates the composition of the gut microbiome in dystonia patients compared to healthy controls. Furthermore, the abundance of neuro-active metabolic pathways, which might be implicated in the (non-)motor symptoms, was investigated. We performed both metagenomic and 16S rRNA sequencing on the stool samples of three subtypes of dystonia (27 cervical dystonia, 20 dopa-responsive... (More)

Dystonia is a movement disorder in which patients have involuntary abnormal movements or postures. Non-motor symptoms, such as psychiatric symptoms, sleep problems and fatigue, are common. We hypothesise that the gut microbiome might play a role in the pathophysiology of the (non-)motor symptoms in dystonia via the gut-brain axis. This exploratory study investigates the composition of the gut microbiome in dystonia patients compared to healthy controls. Furthermore, the abundance of neuro-active metabolic pathways, which might be implicated in the (non-)motor symptoms, was investigated. We performed both metagenomic and 16S rRNA sequencing on the stool samples of three subtypes of dystonia (27 cervical dystonia, 20 dopa-responsive dystonia and 24 myoclonus-dystonia patients) and 25 controls. While microbiome alpha and beta diversity was not different between dystonia patients and controls, dystonia patients had higher abundances of
Ruminococcus torques and
Dorea formicigenerans, and a lower abundance of
Butyrivibrio crossotus compared to controls. For those with dystonia, non-motor symptoms and the levels of neurotransmitters in plasma explained the variance in the gut microbiome composition. Several neuro-active metabolic pathways, especially tryptophan degradation, were less abundant in the dystonia patients compared to controls. This suggest that the gut-brain axis might be involved in the pathophysiology of dystonia. Further studies are necessary to confirm our preliminary findings.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Humans, Dystonia, Gastrointestinal Microbiome/genetics, RNA, Ribosomal, 16S/genetics, Mental Disorders, Dystonic Disorders, Dyskinesias
in
International Journal of Molecular Sciences
volume
24
issue
3
article number
2383
pages
1 - 15
publisher
MDPI AG
external identifiers
  • scopus:85147895279
  • pmid:36768705
ISSN
1422-0067
DOI
10.3390/ijms24032383
language
English
LU publication?
yes
id
10669972-a8a2-40d8-aed4-0371d84410ef
date added to LUP
2023-02-19 19:28:20
date last changed
2024-04-18 08:40:49
@article{10669972-a8a2-40d8-aed4-0371d84410ef,
  abstract     = {{<p>Dystonia is a movement disorder in which patients have involuntary abnormal movements or postures. Non-motor symptoms, such as psychiatric symptoms, sleep problems and fatigue, are common. We hypothesise that the gut microbiome might play a role in the pathophysiology of the (non-)motor symptoms in dystonia via the gut-brain axis. This exploratory study investigates the composition of the gut microbiome in dystonia patients compared to healthy controls. Furthermore, the abundance of neuro-active metabolic pathways, which might be implicated in the (non-)motor symptoms, was investigated. We performed both metagenomic and 16S rRNA sequencing on the stool samples of three subtypes of dystonia (27 cervical dystonia, 20 dopa-responsive dystonia and 24 myoclonus-dystonia patients) and 25 controls. While microbiome alpha and beta diversity was not different between dystonia patients and controls, dystonia patients had higher abundances of<br>
 Ruminococcus torques and <br>
 Dorea formicigenerans, and a lower abundance of <br>
 Butyrivibrio crossotus compared to controls. For those with dystonia, non-motor symptoms and the levels of neurotransmitters in plasma explained the variance in the gut microbiome composition. Several neuro-active metabolic pathways, especially tryptophan degradation, were less abundant in the dystonia patients compared to controls. This suggest that the gut-brain axis might be involved in the pathophysiology of dystonia. Further studies are necessary to confirm our preliminary findings.<br>
 </p>}},
  author       = {{Timmers, Elze R and Swarte, J Casper and Gacesa, Ranko and Björk, Johannes R and Weersma, Rinse K and Tijssen, Marina A J and de Koning, Tom J and Harmsen, Hermie J M and Niezen-Koning, Klary E}},
  issn         = {{1422-0067}},
  keywords     = {{Humans; Dystonia; Gastrointestinal Microbiome/genetics; RNA, Ribosomal, 16S/genetics; Mental Disorders; Dystonic Disorders; Dyskinesias}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{3}},
  pages        = {{1--15}},
  publisher    = {{MDPI AG}},
  series       = {{International Journal of Molecular Sciences}},
  title        = {{Gut Microbiome Composition in Dystonia Patients}},
  url          = {{http://dx.doi.org/10.3390/ijms24032383}},
  doi          = {{10.3390/ijms24032383}},
  volume       = {{24}},
  year         = {{2023}},
}