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Identification of a novel protease inhibitor gene that is highly expressed in the prostate.

Lundwall, Åke LU and Clauss, Adam LU (2002) In Biochemical and Biophysical Research Communications 290(1). p.452-456
Abstract
A novel gene was identified 52 kb upstream of the gene encoding the protease inhibitor elafin (PI3) on human chromosome 20q12-13.1. The transcript of the new gene, denoted huWAP2, was characterized by rapid amplification of cDNA ends and DNA sequencing. The size is 774 bp and it gives rise to a polypeptide of 111 amino acid residues that is homologous to elafin and similar WAP-type protease inhibitors. By RT-PCR it was shown that the gene is highly expressed in prostate, skin, lung, and esophagus.
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Contribution to journal
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subject
keywords
Male, Molecular Sequence Data, Prostate : metabolism, Protease Inhibitors : chemistry, Protein Structure Tertiary, Reverse Transcriptase Polymerase Chain Reaction, Proteins : biosynthesis : chemistry : genetics, Sequence Analysis DNA, Sequence Homology Amino Acid, Sequence Homology Nucleic Acid, Tissue Distribution, Support Non-U.S. Gov't, Exons, Human, DNA Complementary : metabolism, Chromosomes Human Pair 20, Base Sequence, Amino Acid Sequence
in
Biochemical and Biophysical Research Communications
volume
290
issue
1
pages
452 - 456
publisher
Elsevier
external identifiers
  • pmid:11779191
  • wos:000173480900068
  • scopus:0036293860
ISSN
1090-2104
DOI
10.1006/bbrc.2001.6224
language
English
LU publication?
yes
id
8066f229-8a0f-44b7-8d94-ae92ffbfa7dd (old id 106842)
alternative location
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11779191&dopt=Abstract
date added to LUP
2007-07-26 07:56:58
date last changed
2017-04-09 04:22:33
@article{8066f229-8a0f-44b7-8d94-ae92ffbfa7dd,
  abstract     = {A novel gene was identified 52 kb upstream of the gene encoding the protease inhibitor elafin (PI3) on human chromosome 20q12-13.1. The transcript of the new gene, denoted huWAP2, was characterized by rapid amplification of cDNA ends and DNA sequencing. The size is 774 bp and it gives rise to a polypeptide of 111 amino acid residues that is homologous to elafin and similar WAP-type protease inhibitors. By RT-PCR it was shown that the gene is highly expressed in prostate, skin, lung, and esophagus.},
  author       = {Lundwall, Åke and Clauss, Adam},
  issn         = {1090-2104},
  keyword      = {Male,Molecular Sequence Data,Prostate : metabolism,Protease Inhibitors : chemistry,Protein Structure Tertiary,Reverse Transcriptase Polymerase Chain Reaction,Proteins : biosynthesis : chemistry : genetics,Sequence Analysis DNA,Sequence Homology Amino Acid,Sequence Homology Nucleic Acid,Tissue Distribution,Support Non-U.S. Gov't,Exons,Human,DNA Complementary : metabolism,Chromosomes Human Pair 20,Base Sequence,Amino Acid Sequence},
  language     = {eng},
  number       = {1},
  pages        = {452--456},
  publisher    = {Elsevier},
  series       = {Biochemical and Biophysical Research Communications},
  title        = {Identification of a novel protease inhibitor gene that is highly expressed in the prostate.},
  url          = {http://dx.doi.org/10.1006/bbrc.2001.6224},
  volume       = {290},
  year         = {2002},
}