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Identification of susceptibility genes for experimental autoimmune encephalomyelitis that overcome the effect of protective alleles at the eae2 locus.

Jirholt, Johan; Lindqvist, Anna-Karin LU ; Karlsson, Jenny C LU ; Andersson, Åsa LU and Holmdahl, Rikard LU (2002) In International Immunology 14(1). p.79-85
Abstract
We have previously identified a locus on mouse chromosome 15 (eae2) that regulates susceptibility to experimental autoimmune encephalomyelitis in a cross between the susceptible strain B10.RIII and the resistant strain RIIIS/J. In an effort to verify the protective effect from having two RIIIS/J alleles at eae2, the resistant locus was bred into the susceptible strain in homozygous form. However, the expected effect was not as clear as in the original study. This might be due to an epistatic effect conferred by several unidentified genes in the genome of the resistant strain or due to the environment by genotype interactions, possibly overcoming the effect of protective alleles at eae2. To further the genetic understanding in this disease,... (More)
We have previously identified a locus on mouse chromosome 15 (eae2) that regulates susceptibility to experimental autoimmune encephalomyelitis in a cross between the susceptible strain B10.RIII and the resistant strain RIIIS/J. In an effort to verify the protective effect from having two RIIIS/J alleles at eae2, the resistant locus was bred into the susceptible strain in homozygous form. However, the expected effect was not as clear as in the original study. This might be due to an epistatic effect conferred by several unidentified genes in the genome of the resistant strain or due to the environment by genotype interactions, possibly overcoming the effect of protective alleles at eae2. To further the genetic understanding in this disease, a genome-wide linkage screening approach was employed on an F(2) intercross that carried the protective allele at eae2in homozygous form while the rest of the genome segregated between the B10.RIII and RIIIS/J strains as in the original investigation. In the present study we find one region on chromosome 7, not previously identified in this strain combination, that affects the disease at significant logarithm of the odds score and six regions showing suggestive evidence for linkage to disease phenotypes. (Less)
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publication status
published
subject
keywords
Mice Inbred Strains, Mice, Linkage (Genetics), Genetic Predisposition to Disease, Female, Chromosome Mapping, Encephalomyelitis Experimental Autoimmune : genetics, Multigene Family, Support Non-U.S. Gov't, Animal
in
International Immunology
volume
14
issue
1
pages
79 - 85
publisher
Oxford University Press
external identifiers
  • pmid:11751755
  • wos:000173387200010
  • scopus:0036150686
ISSN
1460-2377
DOI
10.1093/intimm/14.1.79
language
English
LU publication?
yes
id
670837f6-d733-4e11-a148-017a6b83de11 (old id 106984)
date added to LUP
2007-07-16 08:50:25
date last changed
2017-01-01 04:32:19
@article{670837f6-d733-4e11-a148-017a6b83de11,
  abstract     = {We have previously identified a locus on mouse chromosome 15 (eae2) that regulates susceptibility to experimental autoimmune encephalomyelitis in a cross between the susceptible strain B10.RIII and the resistant strain RIIIS/J. In an effort to verify the protective effect from having two RIIIS/J alleles at eae2, the resistant locus was bred into the susceptible strain in homozygous form. However, the expected effect was not as clear as in the original study. This might be due to an epistatic effect conferred by several unidentified genes in the genome of the resistant strain or due to the environment by genotype interactions, possibly overcoming the effect of protective alleles at eae2. To further the genetic understanding in this disease, a genome-wide linkage screening approach was employed on an F(2) intercross that carried the protective allele at eae2in homozygous form while the rest of the genome segregated between the B10.RIII and RIIIS/J strains as in the original investigation. In the present study we find one region on chromosome 7, not previously identified in this strain combination, that affects the disease at significant logarithm of the odds score and six regions showing suggestive evidence for linkage to disease phenotypes.},
  author       = {Jirholt, Johan and Lindqvist, Anna-Karin and Karlsson, Jenny C and Andersson, Åsa and Holmdahl, Rikard},
  issn         = {1460-2377},
  keyword      = {Mice Inbred Strains,Mice,Linkage (Genetics),Genetic Predisposition to Disease,Female,Chromosome Mapping,Encephalomyelitis Experimental Autoimmune : genetics,Multigene Family,Support Non-U.S. Gov't,Animal},
  language     = {eng},
  number       = {1},
  pages        = {79--85},
  publisher    = {Oxford University Press},
  series       = {International Immunology},
  title        = {Identification of susceptibility genes for experimental autoimmune encephalomyelitis that overcome the effect of protective alleles at the eae2 locus.},
  url          = {http://dx.doi.org/10.1093/intimm/14.1.79},
  volume       = {14},
  year         = {2002},
}