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Atrial fibrillation episode patterns as predictor of clinical outcome of catheter ablation

Saiz-Vivó, Javier ; Corino, Valentina D.A. ; Martín-Yebra, Alba ; Mainardi, Luca T. ; Hatala, Robert and Sörnmo, Leif LU (2023) In Medical and Biological Engineering and Computing 61(2). p.317-327
Abstract

Methods for characterization of atrial fibrillation (AF) episode patterns have been introduced without establishing clinical significance. This study investigates, for the first time, whether post-ablation recurrence of AF can be predicted by evaluating episode patterns. The dataset comprises of 54 patients (age 56 ± 11 years; 67% men), with an implantable cardiac monitor, before undergoing the first AF catheter ablation. Two parameters of the alternating bivariate Hawkes model were used to characterize the pattern: AF dominance during the monitoring period (log(mu)) and temporal aggregation of episodes (beta1). Moreover, AF burden and AF density, a parameter characterizing aggregation of AF burden, were studied. The four parameters... (More)

Methods for characterization of atrial fibrillation (AF) episode patterns have been introduced without establishing clinical significance. This study investigates, for the first time, whether post-ablation recurrence of AF can be predicted by evaluating episode patterns. The dataset comprises of 54 patients (age 56 ± 11 years; 67% men), with an implantable cardiac monitor, before undergoing the first AF catheter ablation. Two parameters of the alternating bivariate Hawkes model were used to characterize the pattern: AF dominance during the monitoring period (log(mu)) and temporal aggregation of episodes (beta1). Moreover, AF burden and AF density, a parameter characterizing aggregation of AF burden, were studied. The four parameters were computed from an average of 29 AF episodes before ablation. The risk of AF recurrence after catheter ablation using the Hawkes parameters log(mu) and beta1, AF burden, and AF density was evaluated. While the combination of AF burden and AF density is related to a non-significant hazard ratio, the combination of log(mu) and beta1 is related to a hazard ratio of 1.95 (1.03–3.70; p < 0.05). The Hawkes parameters showed increased risk of AF recurrence within 1 year after the procedure for patients with high AF dominance and high episode aggregation and may be used for pre-ablation risk assessment.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Ablation, AF burden, Atrial fibrillation, Recurrence, Temporal aggregation
in
Medical and Biological Engineering and Computing
volume
61
issue
2
pages
317 - 327
publisher
Springer
external identifiers
  • scopus:85142364085
  • pmid:36409405
ISSN
0140-0118
DOI
10.1007/s11517-022-02713-x
language
English
LU publication?
yes
id
106c1b01-40fc-41e4-94a4-100b1ac95a36
date added to LUP
2023-01-20 13:52:51
date last changed
2024-06-13 23:26:12
@article{106c1b01-40fc-41e4-94a4-100b1ac95a36,
  abstract     = {{<p>Methods for characterization of atrial fibrillation (AF) episode patterns have been introduced without establishing clinical significance. This study investigates, for the first time, whether post-ablation recurrence of AF can be predicted by evaluating episode patterns. The dataset comprises of 54 patients (age 56 ± 11 years; 67% men), with an implantable cardiac monitor, before undergoing the first AF catheter ablation. Two parameters of the alternating bivariate Hawkes model were used to characterize the pattern: AF dominance during the monitoring period (log(mu)) and temporal aggregation of episodes (beta1). Moreover, AF burden and AF density, a parameter characterizing aggregation of AF burden, were studied. The four parameters were computed from an average of 29 AF episodes before ablation. The risk of AF recurrence after catheter ablation using the Hawkes parameters log(mu) and beta1, AF burden, and AF density was evaluated. While the combination of AF burden and AF density is related to a non-significant hazard ratio, the combination of log(mu) and beta1 is related to a hazard ratio of 1.95 (1.03–3.70; p &lt; 0.05). The Hawkes parameters showed increased risk of AF recurrence within 1 year after the procedure for patients with high AF dominance and high episode aggregation and may be used for pre-ablation risk assessment. <br/></p>}},
  author       = {{Saiz-Vivó, Javier and Corino, Valentina D.A. and Martín-Yebra, Alba and Mainardi, Luca T. and Hatala, Robert and Sörnmo, Leif}},
  issn         = {{0140-0118}},
  keywords     = {{Ablation; AF burden; Atrial fibrillation; Recurrence; Temporal aggregation}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{317--327}},
  publisher    = {{Springer}},
  series       = {{Medical and Biological Engineering and Computing}},
  title        = {{Atrial fibrillation episode patterns as predictor of clinical outcome of catheter ablation}},
  url          = {{http://dx.doi.org/10.1007/s11517-022-02713-x}},
  doi          = {{10.1007/s11517-022-02713-x}},
  volume       = {{61}},
  year         = {{2023}},
}