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Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response.

Brakebusch, Cord LU ; Fillatreau, Simon; Potocnik, Alexandre J; Bungartz, Gerd; Wilhelm, Patricia; Svensson Frej, Marcus LU ; Kearney, Phil; Körner, Heinrich; Gray, David and Fässler, Reinhard LU (2002) In Immunity 16(3). p.465-477
Abstract
Several experimental evidences suggested that beta1 integrin-mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the beta1 integrin gene restricted to the hematopoietic system, we show that beta1 integrin is not essential for HSC retention in the BM, hematopoiesis, and trafficking of lymphocytes. However, immunization with a T cell-dependent antigen resulted in virtually no IgM production and an increased secretion of IgG in mutant mice, while the response to a T cell-independent type 2 antigen showed decreases in both IgM and IgG. These data suggest that beta1 integrins are necessary for the primary IgM antibody response.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CD29 : immunology, Antigens, CD29 : genetics, Hematopoiesis : genetics, Gene Expression Regulation : immunology, Gene Deletion, B-Lymphocytes : immunology, Immunoglobulin M : biosynthesis, Immunoglobulin M : genetics, Immunoglobulin M : immunology, Mice, Support, Non-U.S. Gov't, T-Lymphocytes : immunology, Antibody Formation : immunology, Animal, Antibody Formation : genetics
in
Immunity
volume
16
issue
3
pages
465 - 477
publisher
Cell Press
external identifiers
  • wos:000174572800014
  • pmid:11911830
  • scopus:18344384036
ISSN
1074-7613
DOI
10.1016/S1074-7613(02)00281-9
language
English
LU publication?
yes
id
b15bb13e-a559-428c-80d8-b76d94c43e97 (old id 107139)
alternative location
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11911830&dopt=Abstract
date added to LUP
2007-07-19 14:25:43
date last changed
2017-03-26 03:38:28
@article{b15bb13e-a559-428c-80d8-b76d94c43e97,
  abstract     = {Several experimental evidences suggested that beta1 integrin-mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the beta1 integrin gene restricted to the hematopoietic system, we show that beta1 integrin is not essential for HSC retention in the BM, hematopoiesis, and trafficking of lymphocytes. However, immunization with a T cell-dependent antigen resulted in virtually no IgM production and an increased secretion of IgG in mutant mice, while the response to a T cell-independent type 2 antigen showed decreases in both IgM and IgG. These data suggest that beta1 integrins are necessary for the primary IgM antibody response.},
  author       = {Brakebusch, Cord and Fillatreau, Simon and Potocnik, Alexandre J and Bungartz, Gerd and Wilhelm, Patricia and Svensson Frej, Marcus and Kearney, Phil and Körner, Heinrich and Gray, David and Fässler, Reinhard},
  issn         = {1074-7613},
  keyword      = {CD29 : immunology,Antigens,CD29 : genetics,Hematopoiesis : genetics,Gene Expression Regulation : immunology,Gene Deletion,B-Lymphocytes : immunology,Immunoglobulin M : biosynthesis,Immunoglobulin M : genetics,Immunoglobulin M : immunology,Mice,Support,Non-U.S. Gov't,T-Lymphocytes : immunology,Antibody Formation : immunology,Animal,Antibody Formation : genetics},
  language     = {eng},
  number       = {3},
  pages        = {465--477},
  publisher    = {Cell Press},
  series       = {Immunity},
  title        = {Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response.},
  url          = {http://dx.doi.org/10.1016/S1074-7613(02)00281-9},
  volume       = {16},
  year         = {2002},
}